Bladder pain syndrome/interstitial cystitis is associated with anxiety disorder

Kuo Hsuan Chung, Shih Ping Liu, Herng Ching Lin, Shiu Dong Chung

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Aim: Recent research demonstrated that bladder pain syndrome/interstitial cystitis (BPS/IC) is associated with many coexisting physical and psychiatric conditions. In this study, we explored the potential association between anxiety disorder (AD) and BPS/IC using a case-controlled population-based approach in Taiwan. Methods: Data on the sampled subjects analyzed in this study were retrieved from the Longitudinal Health Insurance Database 2000. Our study included 396 female cases with BPS/IC and 1,980 randomly selected female controls. We excluded subjects who had a history of major psychosis (except AD) or a substance-related disorder. A conditional logistic regression was performed to calculate the odds ratio (OR) for the association between a previous diagnosis of AD and IC/BPS. Results: Of the 2,376 sampled subjects, 136 (5.72%) had received an AD diagnosis. AD was found in 64 (16.16%) cases and in 72 (3.64%) controls (P <0.001). The conditional logistic regression analysis (conditioned on age group and the index year) suggested that compared to controls, the OR for prior AD among cases was 4.59 (95% confidence interval (CI) = 2.32-9.08, P <0.001). After adjusting for chronic pelvic pain, irritable bowel syndrome, fibromyalgia, migraines, sicca syndrome, allergies, asthma, and an overactive bladder, the OR for prior AD among cases was 4.37 (95% CI = 2.16-8.85, P <0.001) compared to the controls. Conclusions: There was an association between AD and BPS/IC, even after taking demographic characteristics, medical co-morbidities, and substance-related disorders into consideration. Results: of this study should alert clinicians to evaluate and monitor the presence of BPS/IC in patients with AD. Neurourol. Urodynam. 33:101-105, 2014.

Original languageEnglish
Pages (from-to)101-105
Number of pages5
JournalNeurourology and Urodynamics
Volume33
Issue number1
DOIs
Publication statusPublished - Jan 2014

Fingerprint

Interstitial Cystitis
Anxiety Disorders
Urinary Bladder
Pain
Odds Ratio
Substance-Related Disorders
Logistic Models
Confidence Intervals
Overactive Urinary Bladder
Pelvic Pain
Fibromyalgia
Irritable Bowel Syndrome
Sjogren's Syndrome
Health Insurance
Migraine Disorders
Taiwan
Chronic Pain
Psychotic Disorders
Psychiatry
Hypersensitivity

Keywords

  • bladder pain syndrome/interstitial cystitis
  • interstitial cystitis
  • rheumatoid arthritis

ASJC Scopus subject areas

  • Clinical Neurology
  • Urology

Cite this

Bladder pain syndrome/interstitial cystitis is associated with anxiety disorder. / Chung, Kuo Hsuan; Liu, Shih Ping; Lin, Herng Ching; Chung, Shiu Dong.

In: Neurourology and Urodynamics, Vol. 33, No. 1, 01.2014, p. 101-105.

Research output: Contribution to journalArticle

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abstract = "Aim: Recent research demonstrated that bladder pain syndrome/interstitial cystitis (BPS/IC) is associated with many coexisting physical and psychiatric conditions. In this study, we explored the potential association between anxiety disorder (AD) and BPS/IC using a case-controlled population-based approach in Taiwan. Methods: Data on the sampled subjects analyzed in this study were retrieved from the Longitudinal Health Insurance Database 2000. Our study included 396 female cases with BPS/IC and 1,980 randomly selected female controls. We excluded subjects who had a history of major psychosis (except AD) or a substance-related disorder. A conditional logistic regression was performed to calculate the odds ratio (OR) for the association between a previous diagnosis of AD and IC/BPS. Results: Of the 2,376 sampled subjects, 136 (5.72{\%}) had received an AD diagnosis. AD was found in 64 (16.16{\%}) cases and in 72 (3.64{\%}) controls (P <0.001). The conditional logistic regression analysis (conditioned on age group and the index year) suggested that compared to controls, the OR for prior AD among cases was 4.59 (95{\%} confidence interval (CI) = 2.32-9.08, P <0.001). After adjusting for chronic pelvic pain, irritable bowel syndrome, fibromyalgia, migraines, sicca syndrome, allergies, asthma, and an overactive bladder, the OR for prior AD among cases was 4.37 (95{\%} CI = 2.16-8.85, P <0.001) compared to the controls. Conclusions: There was an association between AD and BPS/IC, even after taking demographic characteristics, medical co-morbidities, and substance-related disorders into consideration. Results: of this study should alert clinicians to evaluate and monitor the presence of BPS/IC in patients with AD. Neurourol. Urodynam. 33:101-105, 2014.",
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