Bipolar disorder and schizophrenia present different risks of atrial fibrillation: A nationwide population-based analysis

Hung Yu Yang, Jen Hung Huang, Yung Kuo Lin, Chien-Yeh Hsu, Shih Ann Chen, Yi Jen Chen

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4 Citations (Scopus)

Abstract

Background: Atrial fibrillation (AF) is increasingly prevalent in society, and can elevate cardiac morbidity and mortality. Psychosis and gender are known to play important roles in the genesis of AF. However, it is not clear whether gender modulates the impact of different psychoses on the occurrences of AF. Methods: We identified patients suffering frombipolar disorder and schizophrenia, with and without AF, using the Taiwan National Health Insurance nationwide database. The identified patient population consisted of 927,915 subjects (463,050 males and 464,865 females) from 2001 to 2008, which included 2,963 (3.2‰) schizophrenia patients (1,650 males and 1,313 females) and 5,112 (5.5‰) bipolar-disorder patients (1,934 males and 3,178 females). Results: The male and female bipolar-disorder patients had higher prevalences of AF than did male (16.5‰ vs. 2.4‰, p <0.001) and female (12.9‰ vs. 2.3‰, p <0.001) schizophrenia patients. Furthermore, male and female bipolar-disorder patients had higher AF prevalences than did males (8.5‰, p <0.001) and females (7.2‰, p <0.001) in the general population. Schizophrenia patients had lower AF prevalence than the general population in male, but not in female gender. Males had a higher AF prevalence than females. However, male and female bipolar disorder and schizophrenia patients had similar AF prevalences. Those patients with schizophrenia and bipolar-disorder patients with AF were older than those without AF. Conclusions: Differing risk factors for AF were identified in bipolar-disorder and schizophrenia patients. Compared to the general population, gender may have different impacts on the occurrence of AF in psychosis patients.

Original languageEnglish
Pages (from-to)46-52
Number of pages7
JournalActa Cardiologica Sinica
Volume30
Issue number1
Publication statusPublished - 2014

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Bipolar Disorder
Atrial Fibrillation
Schizophrenia
Population
Psychotic Disorders
National Health Programs
Taiwan
Databases
Morbidity

Keywords

  • Atrial fibrillation
  • Bipolar disorder
  • Population-based study
  • Schizophrenia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

@article{d00eb92ef628457685809a440d057ff4,
title = "Bipolar disorder and schizophrenia present different risks of atrial fibrillation: A nationwide population-based analysis",
abstract = "Background: Atrial fibrillation (AF) is increasingly prevalent in society, and can elevate cardiac morbidity and mortality. Psychosis and gender are known to play important roles in the genesis of AF. However, it is not clear whether gender modulates the impact of different psychoses on the occurrences of AF. Methods: We identified patients suffering frombipolar disorder and schizophrenia, with and without AF, using the Taiwan National Health Insurance nationwide database. The identified patient population consisted of 927,915 subjects (463,050 males and 464,865 females) from 2001 to 2008, which included 2,963 (3.2‰) schizophrenia patients (1,650 males and 1,313 females) and 5,112 (5.5‰) bipolar-disorder patients (1,934 males and 3,178 females). Results: The male and female bipolar-disorder patients had higher prevalences of AF than did male (16.5‰ vs. 2.4‰, p <0.001) and female (12.9‰ vs. 2.3‰, p <0.001) schizophrenia patients. Furthermore, male and female bipolar-disorder patients had higher AF prevalences than did males (8.5‰, p <0.001) and females (7.2‰, p <0.001) in the general population. Schizophrenia patients had lower AF prevalence than the general population in male, but not in female gender. Males had a higher AF prevalence than females. However, male and female bipolar disorder and schizophrenia patients had similar AF prevalences. Those patients with schizophrenia and bipolar-disorder patients with AF were older than those without AF. Conclusions: Differing risk factors for AF were identified in bipolar-disorder and schizophrenia patients. Compared to the general population, gender may have different impacts on the occurrence of AF in psychosis patients.",
keywords = "Atrial fibrillation, Bipolar disorder, Population-based study, Schizophrenia",
author = "Yang, {Hung Yu} and Huang, {Jen Hung} and Lin, {Yung Kuo} and Chien-Yeh Hsu and Chen, {Shih Ann} and Chen, {Yi Jen}",
year = "2014",
language = "English",
volume = "30",
pages = "46--52",
journal = "Acta Cardiologica Sinica",
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T1 - Bipolar disorder and schizophrenia present different risks of atrial fibrillation

T2 - A nationwide population-based analysis

AU - Yang, Hung Yu

AU - Huang, Jen Hung

AU - Lin, Yung Kuo

AU - Hsu, Chien-Yeh

AU - Chen, Shih Ann

AU - Chen, Yi Jen

PY - 2014

Y1 - 2014

N2 - Background: Atrial fibrillation (AF) is increasingly prevalent in society, and can elevate cardiac morbidity and mortality. Psychosis and gender are known to play important roles in the genesis of AF. However, it is not clear whether gender modulates the impact of different psychoses on the occurrences of AF. Methods: We identified patients suffering frombipolar disorder and schizophrenia, with and without AF, using the Taiwan National Health Insurance nationwide database. The identified patient population consisted of 927,915 subjects (463,050 males and 464,865 females) from 2001 to 2008, which included 2,963 (3.2‰) schizophrenia patients (1,650 males and 1,313 females) and 5,112 (5.5‰) bipolar-disorder patients (1,934 males and 3,178 females). Results: The male and female bipolar-disorder patients had higher prevalences of AF than did male (16.5‰ vs. 2.4‰, p <0.001) and female (12.9‰ vs. 2.3‰, p <0.001) schizophrenia patients. Furthermore, male and female bipolar-disorder patients had higher AF prevalences than did males (8.5‰, p <0.001) and females (7.2‰, p <0.001) in the general population. Schizophrenia patients had lower AF prevalence than the general population in male, but not in female gender. Males had a higher AF prevalence than females. However, male and female bipolar disorder and schizophrenia patients had similar AF prevalences. Those patients with schizophrenia and bipolar-disorder patients with AF were older than those without AF. Conclusions: Differing risk factors for AF were identified in bipolar-disorder and schizophrenia patients. Compared to the general population, gender may have different impacts on the occurrence of AF in psychosis patients.

AB - Background: Atrial fibrillation (AF) is increasingly prevalent in society, and can elevate cardiac morbidity and mortality. Psychosis and gender are known to play important roles in the genesis of AF. However, it is not clear whether gender modulates the impact of different psychoses on the occurrences of AF. Methods: We identified patients suffering frombipolar disorder and schizophrenia, with and without AF, using the Taiwan National Health Insurance nationwide database. The identified patient population consisted of 927,915 subjects (463,050 males and 464,865 females) from 2001 to 2008, which included 2,963 (3.2‰) schizophrenia patients (1,650 males and 1,313 females) and 5,112 (5.5‰) bipolar-disorder patients (1,934 males and 3,178 females). Results: The male and female bipolar-disorder patients had higher prevalences of AF than did male (16.5‰ vs. 2.4‰, p <0.001) and female (12.9‰ vs. 2.3‰, p <0.001) schizophrenia patients. Furthermore, male and female bipolar-disorder patients had higher AF prevalences than did males (8.5‰, p <0.001) and females (7.2‰, p <0.001) in the general population. Schizophrenia patients had lower AF prevalence than the general population in male, but not in female gender. Males had a higher AF prevalence than females. However, male and female bipolar disorder and schizophrenia patients had similar AF prevalences. Those patients with schizophrenia and bipolar-disorder patients with AF were older than those without AF. Conclusions: Differing risk factors for AF were identified in bipolar-disorder and schizophrenia patients. Compared to the general population, gender may have different impacts on the occurrence of AF in psychosis patients.

KW - Atrial fibrillation

KW - Bipolar disorder

KW - Population-based study

KW - Schizophrenia

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