Biomedical applications and colloidal properties of amphiphilically modified chitosan hybrids

Mikael Larsson, Wei Chen Huang, Meng Hsuan Hsiao, Yen Jen Wang, Magnus Nydén, Shih Hwa Chiou, Dean Mo Liu

Research output: Contribution to journalReview article

74 Citations (Scopus)

Abstract

Chitosan is among the most abundant biopolymers on earth and has been either used or exhibited potential in a wide variety of industrial and biomedical applications. With the advancement of materials technologies, chitosan has been chemically modified to self-assemble into nanoarchitectures that are usable in advanced biomedical applications, such as drug nanocarriers, macroscopic injectables, tissue-engineering scaffolds, and nanoimaging agents. Colloidal amphiphilically modified chitosan (AMC) is a relatively recent material receiving increased attention with numerous publications addressing the medical advantages of specific systems. To date, many reviews have focused on the synthesis and biomedical properties of chitosan-based biomaterials, but a comprehensive study focusing on the colloidal properties of AMC in relation to biomedical performance appears to be lacking. This review provides a survey of the field, critically reviewing the colloidal properties and biomedical performance of AMC systems, such as nanoparticle drug delivery systems and macroscopic medical devices. Finally, the future development, market potential, and clinical implications of these promising colloidal-structured biomaterials are summarised.

Original languageEnglish
Pages (from-to)1307-1328
Number of pages22
JournalProgress in Polymer Science
Volume38
Issue number9
DOIs
Publication statusPublished - Sep 2013
Externally publishedYes

Keywords

  • Amphiphilic modified chitosan
  • Biomedical applications
  • Colloidal properties

ASJC Scopus subject areas

  • Ceramics and Composites
  • Surfaces and Interfaces
  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

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  • Cite this

    Larsson, M., Huang, W. C., Hsiao, M. H., Wang, Y. J., Nydén, M., Chiou, S. H., & Liu, D. M. (2013). Biomedical applications and colloidal properties of amphiphilically modified chitosan hybrids. Progress in Polymer Science, 38(9), 1307-1328. https://doi.org/10.1016/j.progpolymsci.2013.06.009