Biomarkers of oxidative stress associated with the risk of potentially malignant oral disorders

T. Senghore, Y.-F. Li, F.-C. Sung, M.-H. Tsai, C.-H. Hua, C.-S. Liu, R.-J. Huang, C.-C. Yeh

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Aim: To investigate the effect of oxidative stress biomarkers on the risk of potentially malignant oral disorders (PMODs). Materials and Methods: A total of 208 male adults with PMODs and an equal number of same-age control patients were enrolled. Plasma biomarkers of oxidative stress, measured with 8-hydroxy-2’-deoxyguanosine (8-OHdG) and 8-isoprostane (8-ISO), were determined using enzyme-linked immunosorbent assay (ELISA) kits. PMODs were diagnosed in accordance with the World Health Organization (WHO) guidelines. Results: A significant association between a high level of 8-ISO and an increased risk of PMODs was identified [odds ratio (OR)=1.71, 95% confidence interval (CI)=1.12-2.63; p=0.013]. This positive association was stronger among patients with PMOD subtype of leukoplakia (OR=1.94, 95% Cl=1.24-3.06; p=0.004). However, no significant association was observed between plasma 8-OHdG levels and overall risk of PMODs or subtypes. Conclusion: Increased plasma 8-ISO levels may indicate the prominence of lipid peroxidation in the development of PMODs, particularly leukoplakia. © 2018 International Institute of Anticancer Research. All rights reserved.
Original languageEnglish
Pages (from-to)5211-5216
Number of pages6
JournalAnticancer Research
Volume38
Issue number9
Publication statusPublished - 2018

Keywords

  • Biomarkers
  • Leukoplakia
  • Oxidative stress
  • Potentially malignant oral disorders
  • 8 hydroxydeoxyguanosine
  • 8 isoprostane
  • biological marker
  • genomic DNA
  • 8-epi-prostaglandin F2alpha
  • 8-oxo-7-hydrodeoxyguanosine
  • deoxyguanosine
  • prostaglandin F2 alpha
  • adult
  • alcohol consumption
  • areca nut
  • Article
  • cancer risk
  • case control study
  • cigarette smoking
  • controlled study
  • DNA isolation
  • enzyme linked immunosorbent assay
  • genotyping technique
  • human
  • leukoplakia
  • lipid peroxidation
  • major clinical study
  • male
  • malignant transformation
  • mastication
  • measurement
  • mouth cancer
  • oxidative stress
  • potentially malignant oral disorder
  • priority journal
  • protein blood level
  • risk assessment
  • risk factor
  • analogs and derivatives
  • blood
  • middle aged
  • mouth tumor
  • precancer
  • Adult
  • Deoxyguanosine
  • Dinoprost
  • Humans
  • Lipid Peroxidation
  • Male
  • Middle Aged
  • Mouth Neoplasms
  • Oxidative Stress
  • Precancerous Conditions
  • Risk Factors

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