@article{208825cb5aff48bd99e5c87c93423079,
title = "Biomarkers of oxidative stress associated with the risk of potentially malignant oral disorders",
abstract = "Aim: To investigate the effect of oxidative stress biomarkers on the risk of potentially malignant oral disorders (PMODs). Materials and Methods: A total of 208 male adults with PMODs and an equal number of same-age control patients were enrolled. Plasma biomarkers of oxidative stress, measured with 8-hydroxy-2{\textquoteright}-deoxyguanosine (8-OHdG) and 8-isoprostane (8-ISO), were determined using enzyme-linked immunosorbent assay (ELISA) kits. PMODs were diagnosed in accordance with the World Health Organization (WHO) guidelines. Results: A significant association between a high level of 8-ISO and an increased risk of PMODs was identified [odds ratio (OR)=1.71, 95% confidence interval (CI)=1.12-2.63; p=0.013]. This positive association was stronger among patients with PMOD subtype of leukoplakia (OR=1.94, 95% Cl=1.24-3.06; p=0.004). However, no significant association was observed between plasma 8-OHdG levels and overall risk of PMODs or subtypes. Conclusion: Increased plasma 8-ISO levels may indicate the prominence of lipid peroxidation in the development of PMODs, particularly leukoplakia. {\textcopyright} 2018 International Institute of Anticancer Research. All rights reserved.",
keywords = "Biomarkers, Leukoplakia, Oxidative stress, Potentially malignant oral disorders, 8 hydroxydeoxyguanosine, 8 isoprostane, biological marker, genomic DNA, 8-epi-prostaglandin F2alpha, 8-oxo-7-hydrodeoxyguanosine, deoxyguanosine, prostaglandin F2 alpha, adult, alcohol consumption, areca nut, Article, cancer risk, case control study, cigarette smoking, controlled study, DNA isolation, enzyme linked immunosorbent assay, genotyping technique, human, leukoplakia, lipid peroxidation, major clinical study, male, malignant transformation, mastication, measurement, mouth cancer, oxidative stress, potentially malignant oral disorder, priority journal, protein blood level, risk assessment, risk factor, analogs and derivatives, blood, middle aged, mouth tumor, precancer, Adult, Deoxyguanosine, Dinoprost, Humans, Lipid Peroxidation, Male, Middle Aged, Mouth Neoplasms, Oxidative Stress, Precancerous Conditions, Risk Factors, Biomarkers, Leukoplakia, Oxidative stress, Potentially malignant oral disorders",
author = "T. Senghore and Y.-F. Li and F.-C. Sung and M.-H. Tsai and C.-H. Hua and C.-S. Liu and R.-J. Huang and C.-C. Yeh",
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year = "2018",
language = "English",
volume = "38",
pages = "5211--5216",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "9",
}