Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 5211-5216 |
| Number of pages | 6 |
| Journal | Anticancer Research |
| Volume | 38 |
| Issue number | 9 |
| Publication status | Published - 2018 |
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Keywords
- Biomarkers
- Leukoplakia
- Oxidative stress
- Potentially malignant oral disorders
- 8 hydroxydeoxyguanosine
- 8 isoprostane
- biological marker
- genomic DNA
- 8-epi-prostaglandin F2alpha
- 8-oxo-7-hydrodeoxyguanosine
- deoxyguanosine
- prostaglandin F2 alpha
- adult
- alcohol consumption
- areca nut
- Article
- cancer risk
- case control study
- cigarette smoking
- controlled study
- DNA isolation
- enzyme linked immunosorbent assay
- genotyping technique
- human
- leukoplakia
- lipid peroxidation
- major clinical study
- male
- malignant transformation
- mastication
- measurement
- mouth cancer
- oxidative stress
- potentially malignant oral disorder
- priority journal
- protein blood level
- risk assessment
- risk factor
- analogs and derivatives
- blood
- middle aged
- mouth tumor
- precancer
- Adult
- Deoxyguanosine
- Dinoprost
- Humans
- Lipid Peroxidation
- Male
- Middle Aged
- Mouth Neoplasms
- Oxidative Stress
- Precancerous Conditions
- Risk Factors
Cite this
Biomarkers of oxidative stress associated with the risk of potentially malignant oral disorders. / Senghore, T.; Li, Y.-F.; Sung, F.-C.; Tsai, M.-H.; Hua, C.-H.; Liu, C.-S.; Huang, R.-J.; Yeh, C.-C.
In: Anticancer Research, Vol. 38, No. 9, 2018, p. 5211-5216.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Biomarkers of oxidative stress associated with the risk of potentially malignant oral disorders
AU - Senghore, T.
AU - Li, Y.-F.
AU - Sung, F.-C.
AU - Tsai, M.-H.
AU - Hua, C.-H.
AU - Liu, C.-S.
AU - Huang, R.-J.
AU - Yeh, C.-C.
N1 - Export Date: 18 October 2018 CODEN: ANTRD 通訊地址: Yeh, C.-C.; School of Public Health, College of Public Health, Taipei Medical University, 250 Wu-Hsing Street, Taiwan; 電子郵件: ccyeh@tmu.edu.tw 化學物質/CAS: deoxyguanosine, 961-07-9; prostaglandin F2 alpha, 551-11-1; 8-epi-prostaglandin F2alpha; 8-oxo-7-hydrodeoxyguanosine; Biomarkers; Deoxyguanosine; Dinoprost 參考文獻: Su, C.-C., Tsai, K.-Y., Hsu, Y.-Y., Lin, Y.-Y., Lian, I.-B., Chronic exposure to heavy metals and risk of oral cancer in Taiwanese males (2010) Oral Oncol, 46 (8), pp. 586-590; Swenberg, J.A., Lu, K., Moeller, B.C., Gao, L., Upton, P.B., Nakamura, J., Starr, T.B., Endogenous versus exogenous DNA adducts: Their role in carcinogenesis, epidemiology, and risk assessment (2011) Toxicol Sci, 120, pp. S130-S145; Valko, M., Rhodes, C.J., Moncol, J., Izakovic, M., Mazur, M., Free radicals, metals and antioxidants in oxidative stress-induced cancer (2006) Chem Biol Interact, 160 (1), pp. 1-40; Marczynski, B., Rozynek, P., Kraus, T., Schlosser, S., Raithel, H.J., Baur, X., Levels of 8-hydroxy-2’-deoxyguanosine in DNA of white blood cells from workers highly exposed to asbestos in Germany (2000) Mutat Res, 468 (2), pp. 195-202; 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Poulsen, H.E., Prieme, H., Loft, S., Role of oxidative DNA damage in cancer initiation and promotion (1998) Eur J Cancer Prev, 7 (1), pp. 9-16; Srivastava, K.C., Shrivastava, D., Analysis of plasma lipid peroxidation and antioxidant enzymes status in patients of oral leukoplakia: A case–control study (2016) J Int Soc Prev Community Dent, 6, pp. S213-s218; Ziech, D., Franco, R., Georgakilas, A.G., Georgakila, S., Malamou-Mitsi, V., Schoneveld, O., Pappa, A., Panayiotidis, M.I., The role of reactive oxygen species and oxidative stress in environmental carcinogenesis and biomarker development (2010) Chem Biol Interact, 188 (2), pp. 334-339; Kondo, S., Toyokuni, S., Tanaka, T., Hiai, H., Onodera, H., Kasai, H., Imamura, M., Overexpression of the hOGG1 gene and high 8-hydroxy-2’-deoxyguanosine (8-OHdG) lyase activity in human colorectal carcinoma: Regulation mechanism of the 8-OHdG level in DNA (2000) Clin Cancer Res, 6 (4), pp. 1394-1400; Niedernhofer, L.J., Daniels, J.S., Rouzer, C.A., Greene, R.E., Marnett, L.J., Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells (2003) J Biol Chem, 278 (33), pp. 31426-31433; Jr, R.P., Gammon, M.D., Terry, M.B., Agrawal, M., Zhang, F.F., Teitelbaum, S.L., Eng, S.M., Santella, R.M., Relationship between urinary 15-F2t-isoprostane and 8-oxodeoxyguanosine levels and breast cancer risk (2006) Cancer Epidemiol Biomarkers Prev, 15 (4), pp. 639-644; Brys, M., Morel, A., Forma, E., Krzeslak, A., Wilkosz, J., Rozanski, W., Olas, B., Relationship of urinary isoprostanes to prostate cancer occurrence (2013) Mol Cell Biochem, 372 (1-2), pp. 149-153; Freitas Bde, J., Lloret, G.R., Visacri, M.B., Tuan, B.T., Amaral, L.S., Baldini, D., De Sousa, V.M., Moriel, P., High 15-F2t-isoprostane levels in patients with a previous history of nonmelanoma skin cancer: The effects of supplementary antioxidant therapy (2015) Biomed Res Int, 2015, p. 963569; Benamira, M., Johnson, K., Chaudhary, A., Bruner, K., Tibbetts, C., Marnett, L.J., Induction of mutations by replication of malondialdehyde modified M13 DNA in Escherichia coli: Determination of the extent of DNA modification, genetic requirements for mutagenesis, and types of mutations induced (1995) Carcinogenesis, 16 (1), pp. 93-99; 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PY - 2018
Y1 - 2018
N2 - Aim: To investigate the effect of oxidative stress biomarkers on the risk of potentially malignant oral disorders (PMODs). Materials and Methods: A total of 208 male adults with PMODs and an equal number of same-age control patients were enrolled. Plasma biomarkers of oxidative stress, measured with 8-hydroxy-2’-deoxyguanosine (8-OHdG) and 8-isoprostane (8-ISO), were determined using enzyme-linked immunosorbent assay (ELISA) kits. PMODs were diagnosed in accordance with the World Health Organization (WHO) guidelines. Results: A significant association between a high level of 8-ISO and an increased risk of PMODs was identified [odds ratio (OR)=1.71, 95% confidence interval (CI)=1.12-2.63; p=0.013]. This positive association was stronger among patients with PMOD subtype of leukoplakia (OR=1.94, 95% Cl=1.24-3.06; p=0.004). However, no significant association was observed between plasma 8-OHdG levels and overall risk of PMODs or subtypes. Conclusion: Increased plasma 8-ISO levels may indicate the prominence of lipid peroxidation in the development of PMODs, particularly leukoplakia. © 2018 International Institute of Anticancer Research. All rights reserved.
AB - Aim: To investigate the effect of oxidative stress biomarkers on the risk of potentially malignant oral disorders (PMODs). Materials and Methods: A total of 208 male adults with PMODs and an equal number of same-age control patients were enrolled. Plasma biomarkers of oxidative stress, measured with 8-hydroxy-2’-deoxyguanosine (8-OHdG) and 8-isoprostane (8-ISO), were determined using enzyme-linked immunosorbent assay (ELISA) kits. PMODs were diagnosed in accordance with the World Health Organization (WHO) guidelines. Results: A significant association between a high level of 8-ISO and an increased risk of PMODs was identified [odds ratio (OR)=1.71, 95% confidence interval (CI)=1.12-2.63; p=0.013]. This positive association was stronger among patients with PMOD subtype of leukoplakia (OR=1.94, 95% Cl=1.24-3.06; p=0.004). However, no significant association was observed between plasma 8-OHdG levels and overall risk of PMODs or subtypes. Conclusion: Increased plasma 8-ISO levels may indicate the prominence of lipid peroxidation in the development of PMODs, particularly leukoplakia. © 2018 International Institute of Anticancer Research. All rights reserved.
KW - Biomarkers
KW - Leukoplakia
KW - Oxidative stress
KW - Potentially malignant oral disorders
KW - 8 hydroxydeoxyguanosine
KW - 8 isoprostane
KW - biological marker
KW - genomic DNA
KW - 8-epi-prostaglandin F2alpha
KW - 8-oxo-7-hydrodeoxyguanosine
KW - deoxyguanosine
KW - prostaglandin F2 alpha
KW - adult
KW - alcohol consumption
KW - areca nut
KW - Article
KW - cancer risk
KW - case control study
KW - cigarette smoking
KW - controlled study
KW - DNA isolation
KW - enzyme linked immunosorbent assay
KW - genotyping technique
KW - human
KW - leukoplakia
KW - lipid peroxidation
KW - major clinical study
KW - male
KW - malignant transformation
KW - mastication
KW - measurement
KW - mouth cancer
KW - oxidative stress
KW - potentially malignant oral disorder
KW - priority journal
KW - protein blood level
KW - risk assessment
KW - risk factor
KW - analogs and derivatives
KW - blood
KW - middle aged
KW - mouth tumor
KW - precancer
KW - Adult
KW - Deoxyguanosine
KW - Dinoprost
KW - Humans
KW - Lipid Peroxidation
KW - Male
KW - Middle Aged
KW - Mouth Neoplasms
KW - Oxidative Stress
KW - Precancerous Conditions
KW - Risk Factors
KW - Biomarkers
KW - Leukoplakia
KW - Oxidative stress
KW - Potentially malignant oral disorders
M3 - Article
VL - 38
SP - 5211
EP - 5216
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 9
ER -