Biological mechanisms by which antiproliferative actions of resveratrol are minimized

Yih Ho, Yu Syuan Lin, Hsuan Liang Liu, Ya Jung Shih, Shin Ying Lin, Ai Shih, Yu Tang Chin, Yi Ru Chen, Hung Yun Lin, Paul J. Davis

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Preclinical and clinical studies have offered evidence for protective effects of various polyphenol-rich foods against cardiovascular diseases, neurodegenerative diseases, and cancers. Resveratrol is among the most widely studied polyphenols. However, the preventive and treatment effectiveness of resveratrol in cancer remain controversial because of certain limitations in existing studies. For example, studies of the activity of resveratrol against cancer cell lines in vitro have often been conducted at concentrations in the low μM to mM range, whereas dietary resveratrol or resveratrol-containing wine rarely achieve nM concentrations in the clinic. While the mechanisms underlying the failure of resveratrol to inhibit cancer growth in the intact organism are not fully understood, the interference by thyroid hormones with the anticancer activity of resveratrol have been well documented in both in vitro and xenograft studies. Thus, endogenous thyroid hormones may explain the failure of anticancer actions of resveratrol in intact animals, or in the clinic. In this review, mechanisms involved in resveratrol-induced antiproliferation and effects of thyroid hormones on these mechanisms are discussed.

Original languageEnglish
Article number1046
JournalNutrients
Volume9
Issue number10
DOIs
Publication statusPublished - Oct 1 2017

Fingerprint

resveratrol
thyroid hormones
Thyroid Hormones
Polyphenols
neoplasms
Neoplasms
polyphenols
neurodegenerative diseases
Wine
crossover interference
Heterografts
Neurodegenerative Diseases
cardiovascular diseases
protective effect
wines
clinical trials
Cardiovascular Diseases
cell lines
Cell Line
Food

Keywords

  • Antiproliferation
  • Cancer
  • Nano-diamino-tetrac
  • Resveratrol
  • Tetrac

ASJC Scopus subject areas

  • Food Science

Cite this

Ho, Y., Lin, Y. S., Liu, H. L., Shih, Y. J., Lin, S. Y., Shih, A., ... Davis, P. J. (2017). Biological mechanisms by which antiproliferative actions of resveratrol are minimized. Nutrients, 9(10), [1046]. https://doi.org/10.3390/nu9101046

Biological mechanisms by which antiproliferative actions of resveratrol are minimized. / Ho, Yih; Lin, Yu Syuan; Liu, Hsuan Liang; Shih, Ya Jung; Lin, Shin Ying; Shih, Ai; Chin, Yu Tang; Chen, Yi Ru; Lin, Hung Yun; Davis, Paul J.

In: Nutrients, Vol. 9, No. 10, 1046, 01.10.2017.

Research output: Contribution to journalReview article

Ho, Y, Lin, YS, Liu, HL, Shih, YJ, Lin, SY, Shih, A, Chin, YT, Chen, YR, Lin, HY & Davis, PJ 2017, 'Biological mechanisms by which antiproliferative actions of resveratrol are minimized', Nutrients, vol. 9, no. 10, 1046. https://doi.org/10.3390/nu9101046
Ho, Yih ; Lin, Yu Syuan ; Liu, Hsuan Liang ; Shih, Ya Jung ; Lin, Shin Ying ; Shih, Ai ; Chin, Yu Tang ; Chen, Yi Ru ; Lin, Hung Yun ; Davis, Paul J. / Biological mechanisms by which antiproliferative actions of resveratrol are minimized. In: Nutrients. 2017 ; Vol. 9, No. 10.
@article{c03189d3646b4b89b285afbfef808a39,
title = "Biological mechanisms by which antiproliferative actions of resveratrol are minimized",
abstract = "Preclinical and clinical studies have offered evidence for protective effects of various polyphenol-rich foods against cardiovascular diseases, neurodegenerative diseases, and cancers. Resveratrol is among the most widely studied polyphenols. However, the preventive and treatment effectiveness of resveratrol in cancer remain controversial because of certain limitations in existing studies. For example, studies of the activity of resveratrol against cancer cell lines in vitro have often been conducted at concentrations in the low μM to mM range, whereas dietary resveratrol or resveratrol-containing wine rarely achieve nM concentrations in the clinic. While the mechanisms underlying the failure of resveratrol to inhibit cancer growth in the intact organism are not fully understood, the interference by thyroid hormones with the anticancer activity of resveratrol have been well documented in both in vitro and xenograft studies. Thus, endogenous thyroid hormones may explain the failure of anticancer actions of resveratrol in intact animals, or in the clinic. In this review, mechanisms involved in resveratrol-induced antiproliferation and effects of thyroid hormones on these mechanisms are discussed.",
keywords = "Antiproliferation, Cancer, Nano-diamino-tetrac, Resveratrol, Tetrac",
author = "Yih Ho and Lin, {Yu Syuan} and Liu, {Hsuan Liang} and Shih, {Ya Jung} and Lin, {Shin Ying} and Ai Shih and Chin, {Yu Tang} and Chen, {Yi Ru} and Lin, {Hung Yun} and Davis, {Paul J.}",
year = "2017",
month = "10",
day = "1",
doi = "10.3390/nu9101046",
language = "English",
volume = "9",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "10",

}

TY - JOUR

T1 - Biological mechanisms by which antiproliferative actions of resveratrol are minimized

AU - Ho, Yih

AU - Lin, Yu Syuan

AU - Liu, Hsuan Liang

AU - Shih, Ya Jung

AU - Lin, Shin Ying

AU - Shih, Ai

AU - Chin, Yu Tang

AU - Chen, Yi Ru

AU - Lin, Hung Yun

AU - Davis, Paul J.

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Preclinical and clinical studies have offered evidence for protective effects of various polyphenol-rich foods against cardiovascular diseases, neurodegenerative diseases, and cancers. Resveratrol is among the most widely studied polyphenols. However, the preventive and treatment effectiveness of resveratrol in cancer remain controversial because of certain limitations in existing studies. For example, studies of the activity of resveratrol against cancer cell lines in vitro have often been conducted at concentrations in the low μM to mM range, whereas dietary resveratrol or resveratrol-containing wine rarely achieve nM concentrations in the clinic. While the mechanisms underlying the failure of resveratrol to inhibit cancer growth in the intact organism are not fully understood, the interference by thyroid hormones with the anticancer activity of resveratrol have been well documented in both in vitro and xenograft studies. Thus, endogenous thyroid hormones may explain the failure of anticancer actions of resveratrol in intact animals, or in the clinic. In this review, mechanisms involved in resveratrol-induced antiproliferation and effects of thyroid hormones on these mechanisms are discussed.

AB - Preclinical and clinical studies have offered evidence for protective effects of various polyphenol-rich foods against cardiovascular diseases, neurodegenerative diseases, and cancers. Resveratrol is among the most widely studied polyphenols. However, the preventive and treatment effectiveness of resveratrol in cancer remain controversial because of certain limitations in existing studies. For example, studies of the activity of resveratrol against cancer cell lines in vitro have often been conducted at concentrations in the low μM to mM range, whereas dietary resveratrol or resveratrol-containing wine rarely achieve nM concentrations in the clinic. While the mechanisms underlying the failure of resveratrol to inhibit cancer growth in the intact organism are not fully understood, the interference by thyroid hormones with the anticancer activity of resveratrol have been well documented in both in vitro and xenograft studies. Thus, endogenous thyroid hormones may explain the failure of anticancer actions of resveratrol in intact animals, or in the clinic. In this review, mechanisms involved in resveratrol-induced antiproliferation and effects of thyroid hormones on these mechanisms are discussed.

KW - Antiproliferation

KW - Cancer

KW - Nano-diamino-tetrac

KW - Resveratrol

KW - Tetrac

UR - http://www.scopus.com/inward/record.url?scp=85030099314&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85030099314&partnerID=8YFLogxK

U2 - 10.3390/nu9101046

DO - 10.3390/nu9101046

M3 - Review article

AN - SCOPUS:85030099314

VL - 9

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 10

M1 - 1046

ER -