Biological inhibitory effects of the Chinese herb danggui on brain astrocytoma

Wei Hwa Lee, Jong Shiaw Jin, Wen Chiuan Tsai, Yu Ting Chen, Wen Liang Chang, Chen Wen Yao, Lia Fa Sheu, Ann Chen

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective: Previous studies have demonstrated the utility of the traditional Chinese herb danggui in the treatment of chronic myelogenous leukemia. Our aim was to examine whether it might similarly be used to treat glioblastoma multiforme. Methods: The lipid-soluble active ingredients of danggui were extracted with acetone (AS-AC) or chlorophenol (AS-CH) and their antiproliferative and proapoptotic effects were studied in vitro on cultured GBM 8401 cells and in vivo on tumors in nude mice. Results: After a 24-hour treatment, either AS-AC or AS-CH at a lower (50 μg/ml) and a higher concentration (100 μg/ml) significantly inhibited the proliferative activity of GBM 8401 cultured cells by 30-50%, as well as the expression of cathepsin B and vascular endothelial growth factor (VEGF). In nude mice, the growth of the tumor was inhibited by 30% by AS-CH or AS-AC (20 mg/kg; p

Original languageEnglish
Pages (from-to)141-148
Number of pages8
JournalPathobiology
Volume73
Issue number3
DOIs
Publication statusPublished - 2006

Keywords

  • Astrocytoma, high-grade
  • Danggui

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Biochemistry
  • Immunology and Allergy
  • Cell Biology

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    Lee, W. H., Jin, J. S., Tsai, W. C., Chen, Y. T., Chang, W. L., Yao, C. W., Sheu, L. F., & Chen, A. (2006). Biological inhibitory effects of the Chinese herb danggui on brain astrocytoma. Pathobiology, 73(3), 141-148. https://doi.org/10.1159/000095560