Biological correlates of psychological states among young children: a cross-sectional examination of roles of aspartate transaminase/alanine aminotransferase, insulin, and cytokines

Kuo Hsuan Chung, Chien Ming Hu, Ying Ru Chen, Hung Yi Chiou, Yi Hua Chen

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Compared to data on adolescents and adults, limited research has been conducted on biological correlates among young children with possible psychological difficulties, especially in Asian countries. By focusing on various peripheral biochemical indicators, we investigated potential biological correlates of psychological states in a community sample of Taiwanese school children aged 6–10 years. In total, 307 students (159 obese children and 148 normal-weight children) were selected from first- and fourth-grade school children in eight elementary schools in the Taipei metropolitan area in 2009. These children underwent a comprehensive health examination, including a physical examination, blood sample analysis, and questionnaire administration in a hospital. Differences in anthropometric and serum biochemical readings were compared between children with average and worse levels on each of the five psychological domains. We found that interleukin (IL)-1β [β = 1.29, 95 % confidence interval (CI) 0.50–2.09], IL-10 (β = 1.61, 95 % CI

Original languageEnglish
Pages (from-to)5102-5112
Number of pages11
JournalChinese Science Bulletin
Issue number35
Publication statusPublished - 2014



  • Alanine aminotransferase (ALT)
  • Anxiety
  • Aspartate transaminase (AST)
  • Depression
  • Interleukin-10
  • Interleukin-1β

ASJC Scopus subject areas

  • General

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