Bioengineered corneas for transplantation and in vitro toxicology

Christopher R. McLaughlin, Jui-Fang Tsai, Malcolm A. Latorre, May Griffith

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Bioengineered corneas have been designed to replace partial or the full-thickness of defective corneas, as an alternative to using donor tissues. They range from prosthetic devices that solely address replacement of the cornea's function, to tissue engineered hydrogels that permit regeneration of host tissues. In cases where corneal stem cells have been depleted by injury or disease, most frequently involving the superficial epithelium, tissue engineered lamellar implants reconstructed with stem cells have been transplanted. In situ methods using ultraviolet A (UVA) crosslinking have also been developed to strengthen weakened corneas. In addition to the clinical need, bioengineered corneas are also rapidly gaining importance in the area of in vitro toxicology, as alternatives to animal testing. More complex, fully innervated, physiologically active, three-dimensional organotypic models are also being tested.

Original languageEnglish
Pages (from-to)3326-3337
Number of pages12
JournalFrontiers in Bioscience
Volume14
Issue number9
DOIs
Publication statusPublished - Jan 1 2009

Keywords

  • 3D
  • Artificial
  • Biomimetic
  • Collagen
  • Cornea
  • Crosslinking
  • ECM
  • Extracellular matrix
  • In situ
  • In vitro
  • Innervation
  • Keratoprosthesis
  • PHEMA
  • PMMA
  • Recombinant
  • Review
  • Scaffold
  • Stem cells
  • Tissue engineering
  • Toxicology

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

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  • Cite this

    McLaughlin, C. R., Tsai, J-F., Latorre, M. A., & Griffith, M. (2009). Bioengineered corneas for transplantation and in vitro toxicology. Frontiers in Bioscience, 14(9), 3326-3337. https://doi.org/10.2735/3455