Bioengineered corneas for transplantation and in vitro toxicology

Christopher R. McLaughlin, Jui-Fang Tsai, Malcolm A. Latorre, May Griffith

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Bioengineered corneas have been designed to replace partial or the full-thickness of defective corneas, as an alternative to using donor tissues. They range from prosthetic devices that solely address replacement of the cornea's function, to tissue engineered hydrogels that permit regeneration of host tissues. In cases where corneal stem cells have been depleted by injury or disease, most frequently involving the superficial epithelium, tissue engineered lamellar implants reconstructed with stem cells have been transplanted. In situ methods using ultraviolet A (UVA) crosslinking have also been developed to strengthen weakened corneas. In addition to the clinical need, bioengineered corneas are also rapidly gaining importance in the area of in vitro toxicology, as alternatives to animal testing. More complex, fully innervated, physiologically active, three-dimensional organotypic models are also being tested.

Original languageEnglish
Pages (from-to)3326-3337
Number of pages12
JournalFrontiers in Bioscience
Volume14
Issue number9
DOIs
Publication statusPublished - Jan 1 2009

Fingerprint

Corneal Transplantation
Cornea
Toxicology
Tissue
Stem cells
Animal Testing Alternatives
Stem Cells
Hydrogels
Prosthetics
Crosslinking
Animals
Regeneration
Epithelium
In Vitro Techniques
Tissue Donors
Testing
Equipment and Supplies
Wounds and Injuries

Keywords

  • 3D
  • Artificial
  • Biomimetic
  • Collagen
  • Cornea
  • Crosslinking
  • ECM
  • Extracellular matrix
  • In situ
  • In vitro
  • Innervation
  • Keratoprosthesis
  • PHEMA
  • PMMA
  • Recombinant
  • Review
  • Scaffold
  • Stem cells
  • Tissue engineering
  • Toxicology

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

McLaughlin, C. R., Tsai, J-F., Latorre, M. A., & Griffith, M. (2009). Bioengineered corneas for transplantation and in vitro toxicology. Frontiers in Bioscience, 14(9), 3326-3337. https://doi.org/10.2735/3455

Bioengineered corneas for transplantation and in vitro toxicology. / McLaughlin, Christopher R.; Tsai, Jui-Fang; Latorre, Malcolm A.; Griffith, May.

In: Frontiers in Bioscience, Vol. 14, No. 9, 01.01.2009, p. 3326-3337.

Research output: Contribution to journalArticle

McLaughlin, CR, Tsai, J-F, Latorre, MA & Griffith, M 2009, 'Bioengineered corneas for transplantation and in vitro toxicology', Frontiers in Bioscience, vol. 14, no. 9, pp. 3326-3337. https://doi.org/10.2735/3455
McLaughlin CR, Tsai J-F, Latorre MA, Griffith M. Bioengineered corneas for transplantation and in vitro toxicology. Frontiers in Bioscience. 2009 Jan 1;14(9):3326-3337. https://doi.org/10.2735/3455
McLaughlin, Christopher R. ; Tsai, Jui-Fang ; Latorre, Malcolm A. ; Griffith, May. / Bioengineered corneas for transplantation and in vitro toxicology. In: Frontiers in Bioscience. 2009 ; Vol. 14, No. 9. pp. 3326-3337.
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