Biodegradation patterns of injected composite bone cements in porcine vertebral bodies

A study using quantitative computed tomography

Chi Ching Yeh, Chii Jen Chen, Yun Tang, Kai Chiang Yang, Chang Chin Wu

Research output: Contribution to journalArticle

Abstract

Background: For vertebroplasty, newly synthesized bone cements are proposed to replace traditional polymethylmethacrylate (PMMA). Most inventors initially evaluated these newly developed cements in animal spine models. However, even these time- and work-consuming histological inspections performed meticulously by experienced hands, there are still lots of specimen lost during the processing procedures. Although the histological sections can reveal new bone formations and surrounding tissue reactions to implanted materials, it is difficult to identify the degradation processes of the injected cement. In fact, there is no standard method to quantify the volume changes of injected substitutes postoperation. Methods: Previously, we developed two new biodegradable cements and evaluated performances in fixed-volume and fixed-shaped holes in vertebral bodies of porcine lumbar spine. The animals were sacrificed and the retrieved spines were analyzed after 3 and 6 months. Herein, we further used computed tomography (CT) and three-dimensional CT (3D-CT) to quantitate volumes and biodegradation of cements inside vertebral bodies after previous attestation of CT findings. Exteriors of controls and injected materials were reconstructed with different Hounsfield units (HU); changes of HU as well as cement volumes were later calculated. Results: The results revealed that the volumes and shapes of these biodegradable cements can be determined by 3D-CT. After meticulous comparisons among gross specimens, histologies, and CT images, the different patterns observed in CT implied consistency among all three observations. Gradual reductions of HU and volumes of newly synthesized cements showed the degradability. Meanwhile, consistent HU and volumes of PMMA meant its inertness. Conclusion: CT imaging may be a preliminary, quantitative, and liable way for evaluating injectable bone cements in the vertebral bodies.

Original languageEnglish
Pages (from-to)45-51
Number of pages7
JournalFormosan Journal of Surgery
Volume52
Issue number2
DOIs
Publication statusPublished - Mar 1 2019

Fingerprint

Bone Cements
Swine
Tomography
Spine
Polymethyl Methacrylate
Inventors
Vertebroplasty
Osteogenesis
Histology
Animal Models
Hand
Injections

Keywords

  • Composite bone cement
  • vertebroplasty

ASJC Scopus subject areas

  • Surgery

Cite this

Biodegradation patterns of injected composite bone cements in porcine vertebral bodies : A study using quantitative computed tomography. / Yeh, Chi Ching; Chen, Chii Jen; Tang, Yun; Yang, Kai Chiang; Wu, Chang Chin.

In: Formosan Journal of Surgery, Vol. 52, No. 2, 01.03.2019, p. 45-51.

Research output: Contribution to journalArticle

@article{da5998885fea4c95bcd35be040be860b,
title = "Biodegradation patterns of injected composite bone cements in porcine vertebral bodies: A study using quantitative computed tomography",
abstract = "Background: For vertebroplasty, newly synthesized bone cements are proposed to replace traditional polymethylmethacrylate (PMMA). Most inventors initially evaluated these newly developed cements in animal spine models. However, even these time- and work-consuming histological inspections performed meticulously by experienced hands, there are still lots of specimen lost during the processing procedures. Although the histological sections can reveal new bone formations and surrounding tissue reactions to implanted materials, it is difficult to identify the degradation processes of the injected cement. In fact, there is no standard method to quantify the volume changes of injected substitutes postoperation. Methods: Previously, we developed two new biodegradable cements and evaluated performances in fixed-volume and fixed-shaped holes in vertebral bodies of porcine lumbar spine. The animals were sacrificed and the retrieved spines were analyzed after 3 and 6 months. Herein, we further used computed tomography (CT) and three-dimensional CT (3D-CT) to quantitate volumes and biodegradation of cements inside vertebral bodies after previous attestation of CT findings. Exteriors of controls and injected materials were reconstructed with different Hounsfield units (HU); changes of HU as well as cement volumes were later calculated. Results: The results revealed that the volumes and shapes of these biodegradable cements can be determined by 3D-CT. After meticulous comparisons among gross specimens, histologies, and CT images, the different patterns observed in CT implied consistency among all three observations. Gradual reductions of HU and volumes of newly synthesized cements showed the degradability. Meanwhile, consistent HU and volumes of PMMA meant its inertness. Conclusion: CT imaging may be a preliminary, quantitative, and liable way for evaluating injectable bone cements in the vertebral bodies.",
keywords = "Composite bone cement, vertebroplasty",
author = "Yeh, {Chi Ching} and Chen, {Chii Jen} and Yun Tang and Yang, {Kai Chiang} and Wu, {Chang Chin}",
year = "2019",
month = "3",
day = "1",
doi = "10.4103/fjs.fjs_60_18",
language = "English",
volume = "52",
pages = "45--51",
journal = "Formosan Journal of Surgery",
issn = "1011-6788",
publisher = "臺灣外科醫學會",
number = "2",

}

TY - JOUR

T1 - Biodegradation patterns of injected composite bone cements in porcine vertebral bodies

T2 - A study using quantitative computed tomography

AU - Yeh, Chi Ching

AU - Chen, Chii Jen

AU - Tang, Yun

AU - Yang, Kai Chiang

AU - Wu, Chang Chin

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Background: For vertebroplasty, newly synthesized bone cements are proposed to replace traditional polymethylmethacrylate (PMMA). Most inventors initially evaluated these newly developed cements in animal spine models. However, even these time- and work-consuming histological inspections performed meticulously by experienced hands, there are still lots of specimen lost during the processing procedures. Although the histological sections can reveal new bone formations and surrounding tissue reactions to implanted materials, it is difficult to identify the degradation processes of the injected cement. In fact, there is no standard method to quantify the volume changes of injected substitutes postoperation. Methods: Previously, we developed two new biodegradable cements and evaluated performances in fixed-volume and fixed-shaped holes in vertebral bodies of porcine lumbar spine. The animals were sacrificed and the retrieved spines were analyzed after 3 and 6 months. Herein, we further used computed tomography (CT) and three-dimensional CT (3D-CT) to quantitate volumes and biodegradation of cements inside vertebral bodies after previous attestation of CT findings. Exteriors of controls and injected materials were reconstructed with different Hounsfield units (HU); changes of HU as well as cement volumes were later calculated. Results: The results revealed that the volumes and shapes of these biodegradable cements can be determined by 3D-CT. After meticulous comparisons among gross specimens, histologies, and CT images, the different patterns observed in CT implied consistency among all three observations. Gradual reductions of HU and volumes of newly synthesized cements showed the degradability. Meanwhile, consistent HU and volumes of PMMA meant its inertness. Conclusion: CT imaging may be a preliminary, quantitative, and liable way for evaluating injectable bone cements in the vertebral bodies.

AB - Background: For vertebroplasty, newly synthesized bone cements are proposed to replace traditional polymethylmethacrylate (PMMA). Most inventors initially evaluated these newly developed cements in animal spine models. However, even these time- and work-consuming histological inspections performed meticulously by experienced hands, there are still lots of specimen lost during the processing procedures. Although the histological sections can reveal new bone formations and surrounding tissue reactions to implanted materials, it is difficult to identify the degradation processes of the injected cement. In fact, there is no standard method to quantify the volume changes of injected substitutes postoperation. Methods: Previously, we developed two new biodegradable cements and evaluated performances in fixed-volume and fixed-shaped holes in vertebral bodies of porcine lumbar spine. The animals were sacrificed and the retrieved spines were analyzed after 3 and 6 months. Herein, we further used computed tomography (CT) and three-dimensional CT (3D-CT) to quantitate volumes and biodegradation of cements inside vertebral bodies after previous attestation of CT findings. Exteriors of controls and injected materials were reconstructed with different Hounsfield units (HU); changes of HU as well as cement volumes were later calculated. Results: The results revealed that the volumes and shapes of these biodegradable cements can be determined by 3D-CT. After meticulous comparisons among gross specimens, histologies, and CT images, the different patterns observed in CT implied consistency among all three observations. Gradual reductions of HU and volumes of newly synthesized cements showed the degradability. Meanwhile, consistent HU and volumes of PMMA meant its inertness. Conclusion: CT imaging may be a preliminary, quantitative, and liable way for evaluating injectable bone cements in the vertebral bodies.

KW - Composite bone cement

KW - vertebroplasty

UR - http://www.scopus.com/inward/record.url?scp=85065106510&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065106510&partnerID=8YFLogxK

U2 - 10.4103/fjs.fjs_60_18

DO - 10.4103/fjs.fjs_60_18

M3 - Article

VL - 52

SP - 45

EP - 51

JO - Formosan Journal of Surgery

JF - Formosan Journal of Surgery

SN - 1011-6788

IS - 2

ER -