Biodegradable poly([D,L]-lactide-co-glycolide) nanofibers for the sustainable delivery of lidocaine into the epidural space after laminectomy

Yuan Yun Tseng, Jun Yi Liao, Wei An Chen, Yu Chun Kao, Shih Jung Liu

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Aim: We developed biodegradable, lidocaine-embedded poly([D,L]-lactide-co- glycolide) nanofibers for epidural analgesia to reduce the severe pain in rats after laminectomies. Materials & methods: Nanofibers were prepared by an electrospinning process and were introduced into the epidural space of rats after laminectomy. The lidocaine concentration, postoperative bodyweight change and amount of food/water intake were monitored to evaluate the analgesic effectiveness of the drug-eluting nanofibers. Results: It was demonstrated that the nanofibers provided a sustained release of lidocaine for more than 2 weeks, and the local pharmaceutical concentration was much higher than the concentration in plasma. Rats that received laminectomies without nanofibers exhibited the greatest bodyweight reduction. The food/water intake and activity performance were significantly higher in rats receiving laminectomies with nanofibers than in rats without nanofibers. Conclusion: The results of this study suggest that the lidocaine-loaded nanofibers can provide an easy, practical and safe means of achieving effective postlaminectomy analgesia. Original submitted 23 April 2012; Revised submitted 25 October 2012; Published online 26 June 201.

Original languageEnglish
Pages (from-to)77-87
Number of pages11
JournalNanomedicine
Volume9
Issue number1
DOIs
Publication statusPublished - 2014

Keywords

  • epidural analgesia
  • laminectomy
  • lidocaine
  • nanofiber
  • PLGA

ASJC Scopus subject areas

  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Development

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