Biodegradable nanoparticles for gene therapy technology

Hossein Hosseinkhani, Wen Jie He, Chiao Hsi Chiang, Po Da Hong, Dah Shyong Yu, Abraham J. Domb, Keng Liang Ou

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Rapid propagations in materials technology together with biology have initiated great hopes in the possibility of treating many diseases by gene therapy technology. Viral and non-viral gene carriers are currently applied for gene delivery. Non-viral technology is safe and effective for the delivery of genetic materials to cells and tissues. Non-viral systems are based on plasmid expression containing a gene encoding a therapeutic protein and synthetic biodegradable nanoparticles as a safe carrier of gene. Biodegradable nanoparticles have shown great interest in drug and gene delivery systems as they are easy to be synthesized and have no side effect in cells and tissues. This review provides a critical view of applications of biodegradable nanoparticles on gene therapy technology to enhance the localization of in vitro and in vivo and improve the function of administered genes.

Original languageEnglish
Article number1794
JournalJournal of Nanoparticle Research
Volume15
Issue number7
DOIs
Publication statusPublished - 2013

Keywords

  • DNA
  • Gene expression
  • Gene therapy
  • Non-viral vectors
  • Viral vectors

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Condensed Matter Physics
  • Modelling and Simulation
  • Chemistry(all)
  • Materials Science(all)
  • Bioengineering

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  • Cite this

    Hosseinkhani, H., He, W. J., Chiang, C. H., Hong, P. D., Yu, D. S., Domb, A. J., & Ou, K. L. (2013). Biodegradable nanoparticles for gene therapy technology. Journal of Nanoparticle Research, 15(7), [1794]. https://doi.org/10.1007/s11051-013-1794-z