Biodegradable drug-eluting poly[lactic-co-glycol acid] nanofibers for the sustainable delivery of vancomycin to brain tissue

In vitro and in vivo studies

Yuan Yun Tseng, Yu Chun Kao, Jun Yi Liao, Wei An Chen, Shih Jung Liu

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Successful treatment of a brain infection requires aspiration of the pus or excision of the abscess, followed by long-term (usually 4-8 weeks) parenteral antibiotic treatment. Local antibiotic delivery using biodegradable drug-impregnated carriers is effective in treating postoperative infections, thereby reducing the toxicity associated with parenteral antibiotic treatment and the expense involved with long-term hospitalization. We have developed vancomycin-loaded, biodegradable poly[lactic-co-glycol acid] nanofibrous membranes for the sustainable delivery of vancomycin to the brain tissue of rats by using the electrospinning technique. A high-performance liquid chromatography assay was employed to characterize the in vitro and in vivo release behaviors of pharmaceuticals from the membranes. The experimental results suggested that the biodegradable nanofibers can release high concentrations of vancomycin for more than 8 weeks in the cerebral cavity of rats. Furthermore, the membranes can cover the wall of the cavity after the removal of abscess more completely and achieve better drug delivery without inducing adverse mass effects in the brain. Histological examination also showed no inflammation reaction of the brain tissues. By adopting the biodegradable, nanofibrous drug-eluting membranes, we will be able to achieve long-term deliveries of various antibiotics in the cerebral cavity to enhance the therapeutic efficacy of cerebral infections.

Original languageEnglish
Pages (from-to)1314-1321
Number of pages8
JournalACS Chemical Neuroscience
Volume4
Issue number9
DOIs
Publication statusPublished - Sep 18 2013

Fingerprint

Nanofibers
Glycols
Vancomycin
Brain
Milk
Tissue
Anti-Bacterial Agents
Membranes
Acids
Pharmaceutical Preparations
Abscess
Rats
Infection
Drug Carriers
Suppuration
Electrospinning
High performance liquid chromatography
Encephalitis
Therapeutics
Drug delivery

Keywords

  • biodegradable
  • Brain abscess
  • cerebral infection
  • nanofibers
  • poly[lactic- co -glycol acid]
  • vancomycin

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Physiology
  • Cognitive Neuroscience

Cite this

Biodegradable drug-eluting poly[lactic-co-glycol acid] nanofibers for the sustainable delivery of vancomycin to brain tissue : In vitro and in vivo studies. / Tseng, Yuan Yun; Kao, Yu Chun; Liao, Jun Yi; Chen, Wei An; Liu, Shih Jung.

In: ACS Chemical Neuroscience, Vol. 4, No. 9, 18.09.2013, p. 1314-1321.

Research output: Contribution to journalArticle

@article{e0a0921b51aa4528bfc50e4846702cf0,
title = "Biodegradable drug-eluting poly[lactic-co-glycol acid] nanofibers for the sustainable delivery of vancomycin to brain tissue: In vitro and in vivo studies",
abstract = "Successful treatment of a brain infection requires aspiration of the pus or excision of the abscess, followed by long-term (usually 4-8 weeks) parenteral antibiotic treatment. Local antibiotic delivery using biodegradable drug-impregnated carriers is effective in treating postoperative infections, thereby reducing the toxicity associated with parenteral antibiotic treatment and the expense involved with long-term hospitalization. We have developed vancomycin-loaded, biodegradable poly[lactic-co-glycol acid] nanofibrous membranes for the sustainable delivery of vancomycin to the brain tissue of rats by using the electrospinning technique. A high-performance liquid chromatography assay was employed to characterize the in vitro and in vivo release behaviors of pharmaceuticals from the membranes. The experimental results suggested that the biodegradable nanofibers can release high concentrations of vancomycin for more than 8 weeks in the cerebral cavity of rats. Furthermore, the membranes can cover the wall of the cavity after the removal of abscess more completely and achieve better drug delivery without inducing adverse mass effects in the brain. Histological examination also showed no inflammation reaction of the brain tissues. By adopting the biodegradable, nanofibrous drug-eluting membranes, we will be able to achieve long-term deliveries of various antibiotics in the cerebral cavity to enhance the therapeutic efficacy of cerebral infections.",
keywords = "biodegradable, Brain abscess, cerebral infection, nanofibers, poly[lactic- co -glycol acid], vancomycin",
author = "Tseng, {Yuan Yun} and Kao, {Yu Chun} and Liao, {Jun Yi} and Chen, {Wei An} and Liu, {Shih Jung}",
year = "2013",
month = "9",
day = "18",
doi = "10.1021/cn400108q",
language = "English",
volume = "4",
pages = "1314--1321",
journal = "ACS Chemical Neuroscience",
issn = "1948-7193",
publisher = "American Chemical Society",
number = "9",

}

TY - JOUR

T1 - Biodegradable drug-eluting poly[lactic-co-glycol acid] nanofibers for the sustainable delivery of vancomycin to brain tissue

T2 - In vitro and in vivo studies

AU - Tseng, Yuan Yun

AU - Kao, Yu Chun

AU - Liao, Jun Yi

AU - Chen, Wei An

AU - Liu, Shih Jung

PY - 2013/9/18

Y1 - 2013/9/18

N2 - Successful treatment of a brain infection requires aspiration of the pus or excision of the abscess, followed by long-term (usually 4-8 weeks) parenteral antibiotic treatment. Local antibiotic delivery using biodegradable drug-impregnated carriers is effective in treating postoperative infections, thereby reducing the toxicity associated with parenteral antibiotic treatment and the expense involved with long-term hospitalization. We have developed vancomycin-loaded, biodegradable poly[lactic-co-glycol acid] nanofibrous membranes for the sustainable delivery of vancomycin to the brain tissue of rats by using the electrospinning technique. A high-performance liquid chromatography assay was employed to characterize the in vitro and in vivo release behaviors of pharmaceuticals from the membranes. The experimental results suggested that the biodegradable nanofibers can release high concentrations of vancomycin for more than 8 weeks in the cerebral cavity of rats. Furthermore, the membranes can cover the wall of the cavity after the removal of abscess more completely and achieve better drug delivery without inducing adverse mass effects in the brain. Histological examination also showed no inflammation reaction of the brain tissues. By adopting the biodegradable, nanofibrous drug-eluting membranes, we will be able to achieve long-term deliveries of various antibiotics in the cerebral cavity to enhance the therapeutic efficacy of cerebral infections.

AB - Successful treatment of a brain infection requires aspiration of the pus or excision of the abscess, followed by long-term (usually 4-8 weeks) parenteral antibiotic treatment. Local antibiotic delivery using biodegradable drug-impregnated carriers is effective in treating postoperative infections, thereby reducing the toxicity associated with parenteral antibiotic treatment and the expense involved with long-term hospitalization. We have developed vancomycin-loaded, biodegradable poly[lactic-co-glycol acid] nanofibrous membranes for the sustainable delivery of vancomycin to the brain tissue of rats by using the electrospinning technique. A high-performance liquid chromatography assay was employed to characterize the in vitro and in vivo release behaviors of pharmaceuticals from the membranes. The experimental results suggested that the biodegradable nanofibers can release high concentrations of vancomycin for more than 8 weeks in the cerebral cavity of rats. Furthermore, the membranes can cover the wall of the cavity after the removal of abscess more completely and achieve better drug delivery without inducing adverse mass effects in the brain. Histological examination also showed no inflammation reaction of the brain tissues. By adopting the biodegradable, nanofibrous drug-eluting membranes, we will be able to achieve long-term deliveries of various antibiotics in the cerebral cavity to enhance the therapeutic efficacy of cerebral infections.

KW - biodegradable

KW - Brain abscess

KW - cerebral infection

KW - nanofibers

KW - poly[lactic- co -glycol acid]

KW - vancomycin

UR - http://www.scopus.com/inward/record.url?scp=84884372707&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884372707&partnerID=8YFLogxK

U2 - 10.1021/cn400108q

DO - 10.1021/cn400108q

M3 - Article

VL - 4

SP - 1314

EP - 1321

JO - ACS Chemical Neuroscience

JF - ACS Chemical Neuroscience

SN - 1948-7193

IS - 9

ER -