Biocompatible and multifunctional gold nanorods for effective photothermal therapy of oral squamous cell carcinoma

Yu Te Liao, Chia Hung Liu, Yin Chin, Sin Yuan Chen, Shing Hwa Liu, Yih Chih Hsu, Kevin C.W. Wu

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Herein, a cysteine-functionalized alginate was used to replace cytotoxic cetyltrimethylammonium bromide (CTAB) on gold nanorods (GNRs) by gold-thiol bonding. The characterization shows that the alginate-modified GNRs (GNR@Alg-Cys) were 137 nm in length (measured by zetasizer) with a negative surface charge (-28.4 mV). The GNR@Alg-Cys showed an intense absorption at 800 nm, indicating the potential of GNR@Alg-Cys for NIR-excited photothermal therapy (PTT). To target cancer cells, a cyclic peptide, c(RGDfK)KKK, was further modified on GNR@Alg-Cys (denoted as GNR@Alg-Cys/RGD). In vitro experiments reveal the apparently enhanced cell viability under a high dose of GNRs as well as the death of SAS-3 cell lines exposed to a single-wavelength laser (808 nm). The animal study revealed that the volume of GNR@Alg-Cys/RGD-treated laser-exposed tumor was reduced five times when compared with that in the case of the control group (PBS-treated tumor). Furthermore, the in vivo toxicity of GNR@Alg-Cys/RGD was evaluated, and no significant effect was observed on the functions of liver and kidneys after PTT.

Original languageEnglish
Pages (from-to)4451-4460
Number of pages10
JournalJournal of Materials Chemistry B
Volume7
Issue number28
DOIs
Publication statusPublished - 2019

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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