Biocompatibility and osteoconductivity of the pyrost bone substitutes

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The purpose of this study was to re-evaluate the bone regeneration power and the in vitro biocompatibility of the Pyrost bone substitute. Twenty-four adult New Zealand White rabbits were used. Bony defect over both iliac crest and mid-diaphyseal portion of the ulna bone were created. Appropriate sized-block of Pyrost bone substitute were implanted. Four of the animals were killed at each postoperative month to evaluate its bone regeneration power by histologic study. The Pyrost bones were co-cultured with osteoblasts to evaluate its biocompatibility. The results showed that Pyrost bone substitute was quite stable and incorporated well with active bone regeneration. The Pyrost heal better at the iliac crest than at the ulnar defect. The Pyrost was compatible to the osteoblasts. Osteoblasts had successfully seeded and mitotically expanded on the porous surface of the Pyrost bone graft. The result showed that Pyrost bone obviously exerts an intense stimulus on osteo-regeneration in the presence of osteoblasts. We consider Pyrost to be an alternate to the conventional preserved allografts that is occasionally necessary.

Original languageEnglish
Pages (from-to)19-24
Number of pages6
JournalHistology and Histopathology
Volume12
Issue number1
Publication statusPublished - 1997
Externally publishedYes

Fingerprint

Bone Substitutes
Osteoblasts
Bone Regeneration
Bone and Bones
Pyrost
Ulna
Allografts
Regeneration
Rabbits
Transplants

Keywords

  • biocompatibility
  • osteoconductivity
  • pyrost bone substitute

ASJC Scopus subject areas

  • Cell Biology
  • Anatomy
  • Histology
  • Pathology and Forensic Medicine

Cite this

Biocompatibility and osteoconductivity of the pyrost bone substitutes. / Tsuang, Y. H.

In: Histology and Histopathology, Vol. 12, No. 1, 1997, p. 19-24.

Research output: Contribution to journalArticle

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