Biochemical sensor tubing for point-of-care monitoring of intravenous drugs and metabolites

Charles J. Choi, Hsin Yu Wu, Sherine George, Jonathan Weyhenmeyer, Brian T. Cunningham

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

In medical facilities, there is strong motivation to develop detection systems that can provide continuous analysis of fluids in medical tubing used to either deliver or remove fluids from a patient's body. Possible applications include systems that increase the safety of intravenous (IV) drug injection and point-of-care health monitoring. In this work, we incorporated a surface-enhanced Raman scattering (SERS) sensor comprised of an array of closely spaced metal nanodomes into flexible tubing commonly used for IV drug delivery and urinary catheters. The nanodome sensor was fabricated by a low-cost, large-area process that enables single use disposable operation. As exemplary demonstrations, the sensor was used to kinetically detect promethazine (pain medication) and urea (urinary metabolite) within their clinically relevant concentration ranges. Distinct SERS peaks for each analyte were used to demonstrate separate detection and co-detection of the analytes.

Original languageEnglish
Pages (from-to)574-581
Number of pages8
JournalLab on a Chip - Miniaturisation for Chemistry and Biology
Volume12
Issue number3
DOIs
Publication statusPublished - Feb 7 2012
Externally publishedYes

Fingerprint

Point-of-Care Systems
Raman Spectrum Analysis
Drug Monitoring
Tubing
Metabolites
Promethazine
Urinary Catheters
Raman scattering
Monitoring
Sensors
Intravenous Injections
Pharmaceutical Preparations
Urea
Motivation
Fluids
Catheters
Metals
Drug delivery
Health care
Safety

ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)
  • Bioengineering
  • Biomedical Engineering

Cite this

Biochemical sensor tubing for point-of-care monitoring of intravenous drugs and metabolites. / Choi, Charles J.; Wu, Hsin Yu; George, Sherine; Weyhenmeyer, Jonathan; Cunningham, Brian T.

In: Lab on a Chip - Miniaturisation for Chemistry and Biology, Vol. 12, No. 3, 07.02.2012, p. 574-581.

Research output: Contribution to journalArticle

Choi, Charles J. ; Wu, Hsin Yu ; George, Sherine ; Weyhenmeyer, Jonathan ; Cunningham, Brian T. / Biochemical sensor tubing for point-of-care monitoring of intravenous drugs and metabolites. In: Lab on a Chip - Miniaturisation for Chemistry and Biology. 2012 ; Vol. 12, No. 3. pp. 574-581.
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