Bioactive Y-lactones from the fermented broth of neosartorya sp.

Sien Sing Yang, Guei Jane Wang, Kuo Fang Cheng, Chu Huang Chen, Yu Ming Ju, Ya Jing Tsau, Zong-Huei Li

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Two Y-lactone derivatives, namely neosartolactone (1) and its 7-methyl ester analogue (2), have been isolated from the ethyl acetate extract of the fermented broth of Neosartorya sp. isolated in Taiwan. Structural elucidations of compounds 1 and 2 were achieved on the basis of spectroscopic analysis. Although they had been obtained via the chemical modification of avenaciolide isolated from Aspergillus avenaceus several decades ago, this is the first report to describe them from a natural resource with detailed spectroscopic interpretations. The effects of 1 and 2 on the inhibition of NO production in lipopolysaccharide (LPS)-activated murine macrophages were further evaluated. Compounds 1 and 2 significantly inhibited NO production with the IC50 values of 12.2±1.5 and 11.4±1.0μ M, respectively; but displayed cytotoxicity at considerably higher concentrations than 50μ M.

Original languageEnglish
Pages (from-to)1701-1705
Number of pages5
JournalPlanta Medica
Volume76
Issue number15
DOIs
Publication statusPublished - 2010

Fingerprint

Neosartorya
Lactones
Aspergillus
Taiwan
Inhibitory Concentration 50
Lipopolysaccharides
Esters
Macrophages
Spectroscopic analysis
Chemical modification
Natural resources
Cytotoxicity
Derivatives
ethyl acetate
avenaciolide
Natural Resources

Keywords

  • Ascomycete
  • iNOS
  • mycelium
  • neosartolactone
  • Neosartorya

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Yang, S. S., Wang, G. J., Cheng, K. F., Chen, C. H., Ju, Y. M., Tsau, Y. J., & Li, Z-H. (2010). Bioactive Y-lactones from the fermented broth of neosartorya sp. Planta Medica, 76(15), 1701-1705. https://doi.org/10.1055/s-0030-1249907

Bioactive Y-lactones from the fermented broth of neosartorya sp. / Yang, Sien Sing; Wang, Guei Jane; Cheng, Kuo Fang; Chen, Chu Huang; Ju, Yu Ming; Tsau, Ya Jing; Li, Zong-Huei.

In: Planta Medica, Vol. 76, No. 15, 2010, p. 1701-1705.

Research output: Contribution to journalArticle

Yang, SS, Wang, GJ, Cheng, KF, Chen, CH, Ju, YM, Tsau, YJ & Li, Z-H 2010, 'Bioactive Y-lactones from the fermented broth of neosartorya sp.', Planta Medica, vol. 76, no. 15, pp. 1701-1705. https://doi.org/10.1055/s-0030-1249907
Yang SS, Wang GJ, Cheng KF, Chen CH, Ju YM, Tsau YJ et al. Bioactive Y-lactones from the fermented broth of neosartorya sp. Planta Medica. 2010;76(15):1701-1705. https://doi.org/10.1055/s-0030-1249907
Yang, Sien Sing ; Wang, Guei Jane ; Cheng, Kuo Fang ; Chen, Chu Huang ; Ju, Yu Ming ; Tsau, Ya Jing ; Li, Zong-Huei. / Bioactive Y-lactones from the fermented broth of neosartorya sp. In: Planta Medica. 2010 ; Vol. 76, No. 15. pp. 1701-1705.
@article{003230c9a1ed458da3939ad559b7333d,
title = "Bioactive Y-lactones from the fermented broth of neosartorya sp.",
abstract = "Two Y-lactone derivatives, namely neosartolactone (1) and its 7-methyl ester analogue (2), have been isolated from the ethyl acetate extract of the fermented broth of Neosartorya sp. isolated in Taiwan. Structural elucidations of compounds 1 and 2 were achieved on the basis of spectroscopic analysis. Although they had been obtained via the chemical modification of avenaciolide isolated from Aspergillus avenaceus several decades ago, this is the first report to describe them from a natural resource with detailed spectroscopic interpretations. The effects of 1 and 2 on the inhibition of NO production in lipopolysaccharide (LPS)-activated murine macrophages were further evaluated. Compounds 1 and 2 significantly inhibited NO production with the IC50 values of 12.2±1.5 and 11.4±1.0μ M, respectively; but displayed cytotoxicity at considerably higher concentrations than 50μ M.",
keywords = "Ascomycete, iNOS, mycelium, neosartolactone, Neosartorya",
author = "Yang, {Sien Sing} and Wang, {Guei Jane} and Cheng, {Kuo Fang} and Chen, {Chu Huang} and Ju, {Yu Ming} and Tsau, {Ya Jing} and Zong-Huei Li",
year = "2010",
doi = "10.1055/s-0030-1249907",
language = "English",
volume = "76",
pages = "1701--1705",
journal = "Planta Medica",
issn = "0032-0943",
publisher = "Georg Thieme Verlag",
number = "15",

}

TY - JOUR

T1 - Bioactive Y-lactones from the fermented broth of neosartorya sp.

AU - Yang, Sien Sing

AU - Wang, Guei Jane

AU - Cheng, Kuo Fang

AU - Chen, Chu Huang

AU - Ju, Yu Ming

AU - Tsau, Ya Jing

AU - Li, Zong-Huei

PY - 2010

Y1 - 2010

N2 - Two Y-lactone derivatives, namely neosartolactone (1) and its 7-methyl ester analogue (2), have been isolated from the ethyl acetate extract of the fermented broth of Neosartorya sp. isolated in Taiwan. Structural elucidations of compounds 1 and 2 were achieved on the basis of spectroscopic analysis. Although they had been obtained via the chemical modification of avenaciolide isolated from Aspergillus avenaceus several decades ago, this is the first report to describe them from a natural resource with detailed spectroscopic interpretations. The effects of 1 and 2 on the inhibition of NO production in lipopolysaccharide (LPS)-activated murine macrophages were further evaluated. Compounds 1 and 2 significantly inhibited NO production with the IC50 values of 12.2±1.5 and 11.4±1.0μ M, respectively; but displayed cytotoxicity at considerably higher concentrations than 50μ M.

AB - Two Y-lactone derivatives, namely neosartolactone (1) and its 7-methyl ester analogue (2), have been isolated from the ethyl acetate extract of the fermented broth of Neosartorya sp. isolated in Taiwan. Structural elucidations of compounds 1 and 2 were achieved on the basis of spectroscopic analysis. Although they had been obtained via the chemical modification of avenaciolide isolated from Aspergillus avenaceus several decades ago, this is the first report to describe them from a natural resource with detailed spectroscopic interpretations. The effects of 1 and 2 on the inhibition of NO production in lipopolysaccharide (LPS)-activated murine macrophages were further evaluated. Compounds 1 and 2 significantly inhibited NO production with the IC50 values of 12.2±1.5 and 11.4±1.0μ M, respectively; but displayed cytotoxicity at considerably higher concentrations than 50μ M.

KW - Ascomycete

KW - iNOS

KW - mycelium

KW - neosartolactone

KW - Neosartorya

UR - http://www.scopus.com/inward/record.url?scp=77958576794&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77958576794&partnerID=8YFLogxK

U2 - 10.1055/s-0030-1249907

DO - 10.1055/s-0030-1249907

M3 - Article

VL - 76

SP - 1701

EP - 1705

JO - Planta Medica

JF - Planta Medica

SN - 0032-0943

IS - 15

ER -