Bioactive Y-lactones from the fermented broth of neosartorya sp.

Sien Sing Yang, Guei Jane Wang, Kuo Fang Cheng, Chu Huang Chen, Yu Ming Ju, Ya Jing Tsau, Zong-Huei Li

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Two Y-lactone derivatives, namely neosartolactone (1) and its 7-methyl ester analogue (2), have been isolated from the ethyl acetate extract of the fermented broth of Neosartorya sp. isolated in Taiwan. Structural elucidations of compounds 1 and 2 were achieved on the basis of spectroscopic analysis. Although they had been obtained via the chemical modification of avenaciolide isolated from Aspergillus avenaceus several decades ago, this is the first report to describe them from a natural resource with detailed spectroscopic interpretations. The effects of 1 and 2 on the inhibition of NO production in lipopolysaccharide (LPS)-activated murine macrophages were further evaluated. Compounds 1 and 2 significantly inhibited NO production with the IC50 values of 12.2±1.5 and 11.4±1.0μ M, respectively; but displayed cytotoxicity at considerably higher concentrations than 50μ M.

Original languageEnglish
Pages (from-to)1701-1705
Number of pages5
JournalPlanta Medica
Volume76
Issue number15
DOIs
Publication statusPublished - 2010

Keywords

  • Ascomycete
  • iNOS
  • mycelium
  • neosartolactone
  • Neosartorya

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

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  • Cite this

    Yang, S. S., Wang, G. J., Cheng, K. F., Chen, C. H., Ju, Y. M., Tsau, Y. J., & Li, Z-H. (2010). Bioactive Y-lactones from the fermented broth of neosartorya sp. Planta Medica, 76(15), 1701-1705. https://doi.org/10.1055/s-0030-1249907