Bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum prevent lipopolysaccharide/ d -galactosamine (LPS/ d -GalN)-induced acute hepatitis in mice

Yu Tang Tung, Chi Chang Huang, Shang Tse Ho, Yueh Hsiung Kuo, Chi Chen Lin, Chien Tsong Lin, Jyh Horng Wu

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The purpose of this study was to investigate the bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum on lipopolysaccharide/d- galactosamine (LPS/d-GalN)-induced acute hepatitis. The results revealed that post-treatment with 100 μmol/kg trans-cinnamaldehyde, (α)- aromadendrene, T-cadinol, or α-cadinol significantly decreased the aspartate aminotransferase (AST), alanine aminotransferase (ALT), tumor necrosis factor-α (TNF-α), and interleukin 6 (IL-6) levels in serum. Moreover, both T-cadinol and α-cadinol treatments decreased the expressions of cleaved caspase-3 and cleaved poly-ADP ribose polymerase (PARP) in the liver tissues when compared with the LPS/d-GalN group. Liver histopathology also showed that silymarin, trans-cinnamaldehyde, (α)-aromadendrene, T-cadinol, or α-cadinol significantly reduced the incidence of liver lesions induced by LPS/d-GalN. These results suggest that the above phytochemicals exhibit potent hepatoprotection against LPS/d-GalN-induced liver damage in mice, and their hepatoprotective effects may be due to the modulation of anti-inflammatory activities.

Original languageEnglish
Pages (from-to)8117-8123
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Volume59
Issue number15
DOIs
Publication statusPublished - Aug 10 2011
Externally publishedYes

Fingerprint

Cinnamomum
galactosamine
Galactosamine
Phytochemicals
hepatitis
Volatile Oils
Liver
lipopolysaccharides
Hepatitis
phytopharmaceuticals
Lipopolysaccharides
essential oils
liver
mice
leaves
Silymarin
silymarin
NAD ADP-ribosyltransferase
hepatoprotective effect
Poly(ADP-ribose) Polymerases

Keywords

  • acute liver failure (ALF)
  • Cinnamomum osmophloeum
  • essential oil
  • hepatoprotection
  • lipopolysaccharide/D- galactosamine (LPS/D-GalN)

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

Cite this

Bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum prevent lipopolysaccharide/ d -galactosamine (LPS/ d -GalN)-induced acute hepatitis in mice. / Tung, Yu Tang; Huang, Chi Chang; Ho, Shang Tse; Kuo, Yueh Hsiung; Lin, Chi Chen; Lin, Chien Tsong; Wu, Jyh Horng.

In: Journal of Agricultural and Food Chemistry, Vol. 59, No. 15, 10.08.2011, p. 8117-8123.

Research output: Contribution to journalArticle

Tung, Yu Tang ; Huang, Chi Chang ; Ho, Shang Tse ; Kuo, Yueh Hsiung ; Lin, Chi Chen ; Lin, Chien Tsong ; Wu, Jyh Horng. / Bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum prevent lipopolysaccharide/ d -galactosamine (LPS/ d -GalN)-induced acute hepatitis in mice. In: Journal of Agricultural and Food Chemistry. 2011 ; Vol. 59, No. 15. pp. 8117-8123.
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abstract = "The purpose of this study was to investigate the bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum on lipopolysaccharide/d- galactosamine (LPS/d-GalN)-induced acute hepatitis. The results revealed that post-treatment with 100 μmol/kg trans-cinnamaldehyde, (α)- aromadendrene, T-cadinol, or α-cadinol significantly decreased the aspartate aminotransferase (AST), alanine aminotransferase (ALT), tumor necrosis factor-α (TNF-α), and interleukin 6 (IL-6) levels in serum. Moreover, both T-cadinol and α-cadinol treatments decreased the expressions of cleaved caspase-3 and cleaved poly-ADP ribose polymerase (PARP) in the liver tissues when compared with the LPS/d-GalN group. Liver histopathology also showed that silymarin, trans-cinnamaldehyde, (α)-aromadendrene, T-cadinol, or α-cadinol significantly reduced the incidence of liver lesions induced by LPS/d-GalN. These results suggest that the above phytochemicals exhibit potent hepatoprotection against LPS/d-GalN-induced liver damage in mice, and their hepatoprotective effects may be due to the modulation of anti-inflammatory activities.",
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