Bioactive dipeptide from potato protein hydrolysate combined with swimming exercise prevents high fat diet induced hepatocyte apoptosis by activating PI3K/Akt in SAMP8 mouse

Pei Fang Lai, Rathinasamy Baskaran, Chia Hua Kuo, Cecilia Hsuan Day, Ray Jade Chen, Tsung Jung Ho, Yu Lan Yeh, Viswanadha Vijaya Padma, Chin Hu Lai, Chih Yang Huang

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Obesity in aged population have surges the occurrence of various metabolic disorders including Nonalcoholic fatty liver disease (NAFLD). Apoptosis in the liver is one of the causative factors for NAFLD-induced liver damage. Plants derived bioactive peptides have been shown as an alternative treatment approach for the treating NAFLD due to its less toxicity. Moderate exercise has been reported to improve cellular physiological function prevent age associated metabolic disorders. In the present study, we evaluate the effects of bioactive dipeptide (IF) derived from alcalase potato-protein hydrolysates and swimming exercise in preventing High Fat Diet (HFD)-induced liver damage in senescence accelerated mouse-prone 8 (SAMP8) mice model. Mouse were fed with HFD for 6 weeks followed by oral IF administration or swimming exercise and both for 8 weeks. HFD induces significant structural changes in liver of HFD fed SAMP8 mouse. Both IF administration and exercise prevent the structural abnormalities induced by HFD, however, combined IF treatment and exercise offer better protection. Combined IF treatment and exercise activate PI3K/Akt cell survival protein and effectively inhibit Fas-FADD-induced apoptosis in HFD fed aged mouse. Oral supplementation of bioactive peptide IF combined with moderate swimming exercise effectively alleviate HFD-induced hepatic injury in aged mice.

Original languageEnglish
Pages (from-to)2629-2637
Number of pages9
JournalMolecular Biology Reports
Volume48
Issue number3
DOIs
Publication statusPublished - Mar 2021

Keywords

  • Aging
  • Apoptosis
  • Bioactive peptide
  • High fat diet
  • Obesity

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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