Abstract

Objective To determine whether bilateral electrical stimulation (BiES) of the transected pudendal sensory nerves could further enhance the voiding efficiency beyond that produced by unilateral electrical stimulation (UniES) of transected pudendal afferents in rats with urinary retention. Materials and Methods The efficiency of bladder emptying with either UniES or BiES of pudendal nerve afferents was measured after acute bilateral transection of the sensory branch of the pudendal nerve. The effects of UniES and BiES on voiding in a partially denervated bladder and acute spinal transection, respectively, were determined. Results The voiding efficiency (VE) was reduced from 69 to 22% after bilateral transection of the sensory branch of the pudendal nerve. UniES or BiES increased the VE to 49-62%. Although in most instances BiES consistently generated more efficient bladder emptying than did UniES, these differences were not significant. Both UniES and BiES increased VE after unilateral pelvic nerve transection, demonstrating efficacy in a partially denervated bladder. The enhancement of VE by either UniES or BiES was preserved after acute T 9-T 10, demonstrating the spinal origin of this augmenting reflex. Conclusions The results of the present study are consistent with an essential role for pudendal sensory feedback in efficient bladder emptying, and unilateral and bilateral electrical activation of pudendal nerve afferents are equally efficient in improving bladder emptying in an animal model of urinary retention. This could provide an approach to improve bladder emptying in patients with non-obstructive urinary retention.

Original languageEnglish
Pages (from-to)1051-1058
Number of pages8
JournalBJU International
Volume109
Issue number7
DOIs
Publication statusPublished - Apr 2012

Fingerprint

Urinary Retention
Electric Stimulation
Urinary Bladder
Pudendal Nerve
Sensory Feedback
Reflex

Keywords

  • denervated
  • pelvic nerve
  • voiding efficiency

ASJC Scopus subject areas

  • Urology

Cite this

Bilateral pudendal afferent stimulation improves bladder emptying in rats with urinary retention. / Chen, Shih-Ching; Grill, Warren M.; Fan, Wen Jia; Kou, Yu Ru; Lin, You-Shuei; Lai, Chien-Hung; Peng, Chih-Wei.

In: BJU International, Vol. 109, No. 7, 04.2012, p. 1051-1058.

Research output: Contribution to journalArticle

@article{eed7e9ccb87e4f4badc296213015826d,
title = "Bilateral pudendal afferent stimulation improves bladder emptying in rats with urinary retention",
abstract = "Objective To determine whether bilateral electrical stimulation (BiES) of the transected pudendal sensory nerves could further enhance the voiding efficiency beyond that produced by unilateral electrical stimulation (UniES) of transected pudendal afferents in rats with urinary retention. Materials and Methods The efficiency of bladder emptying with either UniES or BiES of pudendal nerve afferents was measured after acute bilateral transection of the sensory branch of the pudendal nerve. The effects of UniES and BiES on voiding in a partially denervated bladder and acute spinal transection, respectively, were determined. Results The voiding efficiency (VE) was reduced from 69 to 22{\%} after bilateral transection of the sensory branch of the pudendal nerve. UniES or BiES increased the VE to 49-62{\%}. Although in most instances BiES consistently generated more efficient bladder emptying than did UniES, these differences were not significant. Both UniES and BiES increased VE after unilateral pelvic nerve transection, demonstrating efficacy in a partially denervated bladder. The enhancement of VE by either UniES or BiES was preserved after acute T 9-T 10, demonstrating the spinal origin of this augmenting reflex. Conclusions The results of the present study are consistent with an essential role for pudendal sensory feedback in efficient bladder emptying, and unilateral and bilateral electrical activation of pudendal nerve afferents are equally efficient in improving bladder emptying in an animal model of urinary retention. This could provide an approach to improve bladder emptying in patients with non-obstructive urinary retention.",
keywords = "denervated, pelvic nerve, voiding efficiency",
author = "Shih-Ching Chen and Grill, {Warren M.} and Fan, {Wen Jia} and Kou, {Yu Ru} and You-Shuei Lin and Chien-Hung Lai and Chih-Wei Peng",
year = "2012",
month = "4",
doi = "10.1111/j.1464-410X.2011.10526.x",
language = "English",
volume = "109",
pages = "1051--1058",
journal = "BJU International",
issn = "1464-4096",
publisher = "Wiley-Blackwell",
number = "7",

}

TY - JOUR

T1 - Bilateral pudendal afferent stimulation improves bladder emptying in rats with urinary retention

AU - Chen, Shih-Ching

AU - Grill, Warren M.

AU - Fan, Wen Jia

AU - Kou, Yu Ru

AU - Lin, You-Shuei

AU - Lai, Chien-Hung

AU - Peng, Chih-Wei

PY - 2012/4

Y1 - 2012/4

N2 - Objective To determine whether bilateral electrical stimulation (BiES) of the transected pudendal sensory nerves could further enhance the voiding efficiency beyond that produced by unilateral electrical stimulation (UniES) of transected pudendal afferents in rats with urinary retention. Materials and Methods The efficiency of bladder emptying with either UniES or BiES of pudendal nerve afferents was measured after acute bilateral transection of the sensory branch of the pudendal nerve. The effects of UniES and BiES on voiding in a partially denervated bladder and acute spinal transection, respectively, were determined. Results The voiding efficiency (VE) was reduced from 69 to 22% after bilateral transection of the sensory branch of the pudendal nerve. UniES or BiES increased the VE to 49-62%. Although in most instances BiES consistently generated more efficient bladder emptying than did UniES, these differences were not significant. Both UniES and BiES increased VE after unilateral pelvic nerve transection, demonstrating efficacy in a partially denervated bladder. The enhancement of VE by either UniES or BiES was preserved after acute T 9-T 10, demonstrating the spinal origin of this augmenting reflex. Conclusions The results of the present study are consistent with an essential role for pudendal sensory feedback in efficient bladder emptying, and unilateral and bilateral electrical activation of pudendal nerve afferents are equally efficient in improving bladder emptying in an animal model of urinary retention. This could provide an approach to improve bladder emptying in patients with non-obstructive urinary retention.

AB - Objective To determine whether bilateral electrical stimulation (BiES) of the transected pudendal sensory nerves could further enhance the voiding efficiency beyond that produced by unilateral electrical stimulation (UniES) of transected pudendal afferents in rats with urinary retention. Materials and Methods The efficiency of bladder emptying with either UniES or BiES of pudendal nerve afferents was measured after acute bilateral transection of the sensory branch of the pudendal nerve. The effects of UniES and BiES on voiding in a partially denervated bladder and acute spinal transection, respectively, were determined. Results The voiding efficiency (VE) was reduced from 69 to 22% after bilateral transection of the sensory branch of the pudendal nerve. UniES or BiES increased the VE to 49-62%. Although in most instances BiES consistently generated more efficient bladder emptying than did UniES, these differences were not significant. Both UniES and BiES increased VE after unilateral pelvic nerve transection, demonstrating efficacy in a partially denervated bladder. The enhancement of VE by either UniES or BiES was preserved after acute T 9-T 10, demonstrating the spinal origin of this augmenting reflex. Conclusions The results of the present study are consistent with an essential role for pudendal sensory feedback in efficient bladder emptying, and unilateral and bilateral electrical activation of pudendal nerve afferents are equally efficient in improving bladder emptying in an animal model of urinary retention. This could provide an approach to improve bladder emptying in patients with non-obstructive urinary retention.

KW - denervated

KW - pelvic nerve

KW - voiding efficiency

UR - http://www.scopus.com/inward/record.url?scp=84858450684&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858450684&partnerID=8YFLogxK

U2 - 10.1111/j.1464-410X.2011.10526.x

DO - 10.1111/j.1464-410X.2011.10526.x

M3 - Article

VL - 109

SP - 1051

EP - 1058

JO - BJU International

JF - BJU International

SN - 1464-4096

IS - 7

ER -