Big GABA: Edited MR spectroscopy at 24 research sites

Mark Mikkelsen, Peter B. Barker, Pallab K. Bhattacharyya, Maiken K. Brix, Pieter F. Buur, Kim M. Cecil, Kimberly L. Chan, David Y.T. Chen, Alexander R. Craven, Koen Cuypers, Michael Dacko, Niall W. Duncan, Ulrike Dydak, David A. Edmondson, Gabriele Ende, Lars Ersland, Fei Gao, Ian Greenhouse, Ashley D. Harris, Naying He & 40 others Stefanie Heba, Nigel Hoggard, Tun Wei Hsu, Jacobus F.A. Jansen, Alayar Kangarlu, Thomas Lange, R. Marc Lebel, Yan Li, Chien Yuan E. Lin, Jy Kang Liou, Jiing Feng Lirng, Feng Liu, Ruoyun Ma, Celine Maes, Marta Moreno-Ortega, Scott O. Murray, Sean Noah, Ralph Noeske, Michael D. Noseworthy, Georg Oeltzschner, James J. Prisciandaro, Nicolaas A.J. Puts, Timothy P.L. Roberts, Markus Sack, Napapon Sailasuta, Muhammad G. Saleh, Michael Paul Schallmo, Nicholas Simard, Stephan P. Swinnen, Martin Tegenthoff, Peter Truong, Guangbin Wang, Iain D. Wilkinson, Hans Jörg Wittsack, Hongmin Xu, Fuhua Yan, Chencheng Zhang, Vadim Zipunnikov, Helge J. Zöllner, Richard A.E. Edden

Research output: Contribution to journalArticle

  • 13 Citations

Abstract

Magnetic resonance spectroscopy (MRS) is the only biomedical imaging method that can noninvasively detect endogenous signals from the neurotransmitter γ-aminobutyric acid (GABA) in the human brain. Its increasing popularity has been aided by improvements in scanner hardware and acquisition methodology, as well as by broader access to pulse sequences that can selectively detect GABA, in particular J-difference spectral editing sequences. Nevertheless, implementations of GABA-edited MRS remain diverse across research sites, making comparisons between studies challenging. This large-scale multi-vendor, multi-site study seeks to better understand the factors that impact measurement outcomes of GABA-edited MRS. An international consortium of 24 research sites was formed. Data from 272 healthy adults were acquired on scanners from the three major MRI vendors and analyzed using the Gannet processing pipeline. MRS data were acquired in the medial parietal lobe with standard GABA+ and macromolecule- (MM-) suppressed GABA editing. The coefficient of variation across the entire cohort was 12% for GABA+ measurements and 28% for MM-suppressed GABA measurements. A multilevel analysis revealed that most of the variance (72%) in the GABA+ data was accounted for by differences between participants within-site, while site-level differences accounted for comparatively more variance (20%) than vendor-level differences (8%). For MM-suppressed GABA data, the variance was distributed equally between site- (50%) and participant-level (50%) differences. The findings show that GABA+ measurements exhibit strong agreement when implemented with a standard protocol. There is, however, increased variability for MM-suppressed GABA measurements that is attributed in part to differences in site-to-site data acquisition. This study's protocol establishes a framework for future methodological standardization of GABA-edited MRS, while the results provide valuable benchmarks for the MRS community.

LanguageEnglish
Pages32-45
Number of pages14
JournalNeuroImage
Volume159
DOIs
Publication statusPublished - Oct 1 2017

Fingerprint

gamma-Aminobutyric Acid
Magnetic Resonance Spectroscopy
Research
Multilevel Analysis
Benchmarking
Parietal Lobe
Neurotransmitter Agents

Keywords

  • Editing
  • GABA
  • MEGA-PRESS
  • MRS
  • Multi-site study

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

Mikkelsen, M., Barker, P. B., Bhattacharyya, P. K., Brix, M. K., Buur, P. F., Cecil, K. M., ... Edden, R. A. E. (2017). Big GABA: Edited MR spectroscopy at 24 research sites. NeuroImage, 159, 32-45. https://doi.org/10.1016/j.neuroimage.2017.07.021

Big GABA : Edited MR spectroscopy at 24 research sites. / Mikkelsen, Mark; Barker, Peter B.; Bhattacharyya, Pallab K.; Brix, Maiken K.; Buur, Pieter F.; Cecil, Kim M.; Chan, Kimberly L.; Chen, David Y.T.; Craven, Alexander R.; Cuypers, Koen; Dacko, Michael; Duncan, Niall W.; Dydak, Ulrike; Edmondson, David A.; Ende, Gabriele; Ersland, Lars; Gao, Fei; Greenhouse, Ian; Harris, Ashley D.; He, Naying; Heba, Stefanie; Hoggard, Nigel; Hsu, Tun Wei; Jansen, Jacobus F.A.; Kangarlu, Alayar; Lange, Thomas; Lebel, R. Marc; Li, Yan; Lin, Chien Yuan E.; Liou, Jy Kang; Lirng, Jiing Feng; Liu, Feng; Ma, Ruoyun; Maes, Celine; Moreno-Ortega, Marta; Murray, Scott O.; Noah, Sean; Noeske, Ralph; Noseworthy, Michael D.; Oeltzschner, Georg; Prisciandaro, James J.; Puts, Nicolaas A.J.; Roberts, Timothy P.L.; Sack, Markus; Sailasuta, Napapon; Saleh, Muhammad G.; Schallmo, Michael Paul; Simard, Nicholas; Swinnen, Stephan P.; Tegenthoff, Martin; Truong, Peter; Wang, Guangbin; Wilkinson, Iain D.; Wittsack, Hans Jörg; Xu, Hongmin; Yan, Fuhua; Zhang, Chencheng; Zipunnikov, Vadim; Zöllner, Helge J.; Edden, Richard A.E.

In: NeuroImage, Vol. 159, 01.10.2017, p. 32-45.

Research output: Contribution to journalArticle

Mikkelsen, M, Barker, PB, Bhattacharyya, PK, Brix, MK, Buur, PF, Cecil, KM, Chan, KL, Chen, DYT, Craven, AR, Cuypers, K, Dacko, M, Duncan, NW, Dydak, U, Edmondson, DA, Ende, G, Ersland, L, Gao, F, Greenhouse, I, Harris, AD, He, N, Heba, S, Hoggard, N, Hsu, TW, Jansen, JFA, Kangarlu, A, Lange, T, Lebel, RM, Li, Y, Lin, CYE, Liou, JK, Lirng, JF, Liu, F, Ma, R, Maes, C, Moreno-Ortega, M, Murray, SO, Noah, S, Noeske, R, Noseworthy, MD, Oeltzschner, G, Prisciandaro, JJ, Puts, NAJ, Roberts, TPL, Sack, M, Sailasuta, N, Saleh, MG, Schallmo, MP, Simard, N, Swinnen, SP, Tegenthoff, M, Truong, P, Wang, G, Wilkinson, ID, Wittsack, HJ, Xu, H, Yan, F, Zhang, C, Zipunnikov, V, Zöllner, HJ & Edden, RAE 2017, 'Big GABA: Edited MR spectroscopy at 24 research sites' NeuroImage, vol. 159, pp. 32-45. https://doi.org/10.1016/j.neuroimage.2017.07.021
Mikkelsen M, Barker PB, Bhattacharyya PK, Brix MK, Buur PF, Cecil KM et al. Big GABA: Edited MR spectroscopy at 24 research sites. NeuroImage. 2017 Oct 1;159:32-45. https://doi.org/10.1016/j.neuroimage.2017.07.021
Mikkelsen, Mark ; Barker, Peter B. ; Bhattacharyya, Pallab K. ; Brix, Maiken K. ; Buur, Pieter F. ; Cecil, Kim M. ; Chan, Kimberly L. ; Chen, David Y.T. ; Craven, Alexander R. ; Cuypers, Koen ; Dacko, Michael ; Duncan, Niall W. ; Dydak, Ulrike ; Edmondson, David A. ; Ende, Gabriele ; Ersland, Lars ; Gao, Fei ; Greenhouse, Ian ; Harris, Ashley D. ; He, Naying ; Heba, Stefanie ; Hoggard, Nigel ; Hsu, Tun Wei ; Jansen, Jacobus F.A. ; Kangarlu, Alayar ; Lange, Thomas ; Lebel, R. Marc ; Li, Yan ; Lin, Chien Yuan E. ; Liou, Jy Kang ; Lirng, Jiing Feng ; Liu, Feng ; Ma, Ruoyun ; Maes, Celine ; Moreno-Ortega, Marta ; Murray, Scott O. ; Noah, Sean ; Noeske, Ralph ; Noseworthy, Michael D. ; Oeltzschner, Georg ; Prisciandaro, James J. ; Puts, Nicolaas A.J. ; Roberts, Timothy P.L. ; Sack, Markus ; Sailasuta, Napapon ; Saleh, Muhammad G. ; Schallmo, Michael Paul ; Simard, Nicholas ; Swinnen, Stephan P. ; Tegenthoff, Martin ; Truong, Peter ; Wang, Guangbin ; Wilkinson, Iain D. ; Wittsack, Hans Jörg ; Xu, Hongmin ; Yan, Fuhua ; Zhang, Chencheng ; Zipunnikov, Vadim ; Zöllner, Helge J. ; Edden, Richard A.E. / Big GABA : Edited MR spectroscopy at 24 research sites. In: NeuroImage. 2017 ; Vol. 159. pp. 32-45.
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AU - Bhattacharyya, Pallab K.

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AU - Schallmo, Michael Paul

AU - Simard, Nicholas

AU - Swinnen, Stephan P.

AU - Tegenthoff, Martin

AU - Truong, Peter

AU - Wang, Guangbin

AU - Wilkinson, Iain D.

AU - Wittsack, Hans Jörg

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AU - Yan, Fuhua

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AU - Zipunnikov, Vadim

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