Bezold-Jarisch-like reflex during radiofrequency ablation of the pulmonary vein tissues in patients with paroxysmal focal atrial fibrillation

Chin Feng Tsai, Shih Ann Chen, Ching Tai Tai, Chuen Wang Chiou, V. S. Prakash, Wen Chung Yu, Ming Hsiung Hsieh, Yu An Ding, Mau Song Chang

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Introduction: Information is lacking about the occurrence of ablation- related proarrhythmic events during application of radiofrequency (RF) energy at the pulmonary veins in patients with paroxysmal focal atrial fibrillation. The purpose of this study was to assess the theoretical risk of reflex bradycardia and hypotension response during RF ablation of these regions rich in endocardial nerve terminals. Methods and Results: Among the 40 consecutive patients (29 men, 11 women; mean age 65 ± 12 years) with clinically documented frequent attacks of paroxysmal atrial fibrillation who underwent superior pulmonary vein ablation for left focal atrial fibrillation, 6 patients (15%) developed bradycardia-hypotension syndrome during energy delivery. A single atrial fibrillation trigger focus in the left or right superior pulmonary vein was found in 3 and 1 patients, respectively. Two patients had two trigger foci originating from the orifice or proximal part of both superior pulmonary veins. After RF current was applied for a period of 14 ± 10 seconds, 2 patients developed junctional rhythm and sinus bradycardia, another 2 patients had profound sinus bradycardia, 1 patient had two episodes of sudden onset of complete AV block with resultant 9.5-second asystole, and 1 patient showed profound sinus bradycardia, transient AV block, and an 8-second asystole due to sinus arrest. Blood pressure fell when any substantial bradyarrhythmias occurred. All 6 patients were free of rhythm disturbances during the postablation follow-up period (mean 8 ± 2 months). Conclusion: RF catheter ablation of the pulmonary vein tissues could evoke a variety of profound bradycardia-hypotension responses. The Bezold-Jarisch- like reflex might be the underlying mechanism.

Original languageEnglish
Pages (from-to)27-35
Number of pages9
JournalJournal of Cardiovascular Electrophysiology
Volume10
Issue number1
Publication statusPublished - 1999
Externally publishedYes

Fingerprint

Pulmonary Veins
Atrial Fibrillation
Reflex
Bradycardia
Hypotension
Atrioventricular Block
Heart Arrest
Catheter Ablation
Blood Pressure

Keywords

  • Ablation
  • Bradycardia
  • Focal atrial fibrillation
  • Pulmonary vein

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Bezold-Jarisch-like reflex during radiofrequency ablation of the pulmonary vein tissues in patients with paroxysmal focal atrial fibrillation. / Tsai, Chin Feng; Chen, Shih Ann; Tai, Ching Tai; Chiou, Chuen Wang; Prakash, V. S.; Yu, Wen Chung; Hsieh, Ming Hsiung; Ding, Yu An; Chang, Mau Song.

In: Journal of Cardiovascular Electrophysiology, Vol. 10, No. 1, 1999, p. 27-35.

Research output: Contribution to journalArticle

Tsai, Chin Feng ; Chen, Shih Ann ; Tai, Ching Tai ; Chiou, Chuen Wang ; Prakash, V. S. ; Yu, Wen Chung ; Hsieh, Ming Hsiung ; Ding, Yu An ; Chang, Mau Song. / Bezold-Jarisch-like reflex during radiofrequency ablation of the pulmonary vein tissues in patients with paroxysmal focal atrial fibrillation. In: Journal of Cardiovascular Electrophysiology. 1999 ; Vol. 10, No. 1. pp. 27-35.
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abstract = "Introduction: Information is lacking about the occurrence of ablation- related proarrhythmic events during application of radiofrequency (RF) energy at the pulmonary veins in patients with paroxysmal focal atrial fibrillation. The purpose of this study was to assess the theoretical risk of reflex bradycardia and hypotension response during RF ablation of these regions rich in endocardial nerve terminals. Methods and Results: Among the 40 consecutive patients (29 men, 11 women; mean age 65 ± 12 years) with clinically documented frequent attacks of paroxysmal atrial fibrillation who underwent superior pulmonary vein ablation for left focal atrial fibrillation, 6 patients (15{\%}) developed bradycardia-hypotension syndrome during energy delivery. A single atrial fibrillation trigger focus in the left or right superior pulmonary vein was found in 3 and 1 patients, respectively. Two patients had two trigger foci originating from the orifice or proximal part of both superior pulmonary veins. After RF current was applied for a period of 14 ± 10 seconds, 2 patients developed junctional rhythm and sinus bradycardia, another 2 patients had profound sinus bradycardia, 1 patient had two episodes of sudden onset of complete AV block with resultant 9.5-second asystole, and 1 patient showed profound sinus bradycardia, transient AV block, and an 8-second asystole due to sinus arrest. Blood pressure fell when any substantial bradyarrhythmias occurred. All 6 patients were free of rhythm disturbances during the postablation follow-up period (mean 8 ± 2 months). Conclusion: RF catheter ablation of the pulmonary vein tissues could evoke a variety of profound bradycardia-hypotension responses. The Bezold-Jarisch- like reflex might be the underlying mechanism.",
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T1 - Bezold-Jarisch-like reflex during radiofrequency ablation of the pulmonary vein tissues in patients with paroxysmal focal atrial fibrillation

AU - Tsai, Chin Feng

AU - Chen, Shih Ann

AU - Tai, Ching Tai

AU - Chiou, Chuen Wang

AU - Prakash, V. S.

AU - Yu, Wen Chung

AU - Hsieh, Ming Hsiung

AU - Ding, Yu An

AU - Chang, Mau Song

PY - 1999

Y1 - 1999

N2 - Introduction: Information is lacking about the occurrence of ablation- related proarrhythmic events during application of radiofrequency (RF) energy at the pulmonary veins in patients with paroxysmal focal atrial fibrillation. The purpose of this study was to assess the theoretical risk of reflex bradycardia and hypotension response during RF ablation of these regions rich in endocardial nerve terminals. Methods and Results: Among the 40 consecutive patients (29 men, 11 women; mean age 65 ± 12 years) with clinically documented frequent attacks of paroxysmal atrial fibrillation who underwent superior pulmonary vein ablation for left focal atrial fibrillation, 6 patients (15%) developed bradycardia-hypotension syndrome during energy delivery. A single atrial fibrillation trigger focus in the left or right superior pulmonary vein was found in 3 and 1 patients, respectively. Two patients had two trigger foci originating from the orifice or proximal part of both superior pulmonary veins. After RF current was applied for a period of 14 ± 10 seconds, 2 patients developed junctional rhythm and sinus bradycardia, another 2 patients had profound sinus bradycardia, 1 patient had two episodes of sudden onset of complete AV block with resultant 9.5-second asystole, and 1 patient showed profound sinus bradycardia, transient AV block, and an 8-second asystole due to sinus arrest. Blood pressure fell when any substantial bradyarrhythmias occurred. All 6 patients were free of rhythm disturbances during the postablation follow-up period (mean 8 ± 2 months). Conclusion: RF catheter ablation of the pulmonary vein tissues could evoke a variety of profound bradycardia-hypotension responses. The Bezold-Jarisch- like reflex might be the underlying mechanism.

AB - Introduction: Information is lacking about the occurrence of ablation- related proarrhythmic events during application of radiofrequency (RF) energy at the pulmonary veins in patients with paroxysmal focal atrial fibrillation. The purpose of this study was to assess the theoretical risk of reflex bradycardia and hypotension response during RF ablation of these regions rich in endocardial nerve terminals. Methods and Results: Among the 40 consecutive patients (29 men, 11 women; mean age 65 ± 12 years) with clinically documented frequent attacks of paroxysmal atrial fibrillation who underwent superior pulmonary vein ablation for left focal atrial fibrillation, 6 patients (15%) developed bradycardia-hypotension syndrome during energy delivery. A single atrial fibrillation trigger focus in the left or right superior pulmonary vein was found in 3 and 1 patients, respectively. Two patients had two trigger foci originating from the orifice or proximal part of both superior pulmonary veins. After RF current was applied for a period of 14 ± 10 seconds, 2 patients developed junctional rhythm and sinus bradycardia, another 2 patients had profound sinus bradycardia, 1 patient had two episodes of sudden onset of complete AV block with resultant 9.5-second asystole, and 1 patient showed profound sinus bradycardia, transient AV block, and an 8-second asystole due to sinus arrest. Blood pressure fell when any substantial bradyarrhythmias occurred. All 6 patients were free of rhythm disturbances during the postablation follow-up period (mean 8 ± 2 months). Conclusion: RF catheter ablation of the pulmonary vein tissues could evoke a variety of profound bradycardia-hypotension responses. The Bezold-Jarisch- like reflex might be the underlying mechanism.

KW - Ablation

KW - Bradycardia

KW - Focal atrial fibrillation

KW - Pulmonary vein

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