Beta-cell function and insulin sensitivity at various degrees of glucose tolerance in Chinese subjects

Jiunn Diann Lin, Yen Lin Chen, Chun Hsien Hsu, Chung Ze Wu, An-Tsz Hsieh, Chang Hsun Hsieh, Jin Biou Chang, Yao Jen Liang, Dee Pei

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Aims: The aim of this study was to evaluate the relative importance of insulin sensitivity (SI), and the first (1st ISEC) and second phase insulin secretion (2nd ISEC) in the development of type 2 diabetes (T2D) in Chinese subjects. Methods: A total of 96 subjects, including 19 with normal fasting glucose, 21 with pre-diabetes, and 56 with T2D were enrolled. Subjects underwent a modified low dose graded glucose infusion (M-LDGGI; a simplified version of Polonsky's method) and frequently sampled intravenous glucose tolerance test. The results were interpreted as the slope of the changes of plasma insulin against the glucose levels. By observing the respective percentage reduction, the deterioration rate of each parameter was compared. Results: As fasting plasma glucose (FPG) levels increased, SI decreased mildly and non-significantly, while the 1st and 2nd ISECs decreased more dramatically and significantly. More importantly, the decrease of the 1st ISEC from baseline was greater than that of the 2nd ISEC. Conclusions: Since the 1st ISEC decreased the most with increasing FPG levels, it is concluded that the 1st ISEC is the key trigger of T2D development. On the contrary, the 2nd ISEC remained more stable across increasing FPG levels. This latter finding may explain the effectiveness of insulin secretagogues during the early stage of T2D. The results of this study can be helpful in the development of interventions aimed at stopping the progression and/or treating T2D in Chinese populations.

Original languageEnglish
Pages (from-to)391-397
Number of pages7
JournalDiabetes Research and Clinical Practice
Volume100
Issue number3
DOIs
Publication statusPublished - Jun 2013

Fingerprint

Insulin Resistance
Type 2 Diabetes Mellitus
Glucose
Fasting
Insulin
Glucose Tolerance Test
Population

Keywords

  • First phase insulin secretion
  • Second phase insulin secretion
  • Type 2 diabetes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Endocrinology

Cite this

Beta-cell function and insulin sensitivity at various degrees of glucose tolerance in Chinese subjects. / Lin, Jiunn Diann; Chen, Yen Lin; Hsu, Chun Hsien; Wu, Chung Ze; Hsieh, An-Tsz; Hsieh, Chang Hsun; Chang, Jin Biou; Liang, Yao Jen; Pei, Dee.

In: Diabetes Research and Clinical Practice, Vol. 100, No. 3, 06.2013, p. 391-397.

Research output: Contribution to journalArticle

Lin, Jiunn Diann ; Chen, Yen Lin ; Hsu, Chun Hsien ; Wu, Chung Ze ; Hsieh, An-Tsz ; Hsieh, Chang Hsun ; Chang, Jin Biou ; Liang, Yao Jen ; Pei, Dee. / Beta-cell function and insulin sensitivity at various degrees of glucose tolerance in Chinese subjects. In: Diabetes Research and Clinical Practice. 2013 ; Vol. 100, No. 3. pp. 391-397.
@article{ef132f4043e64d9c9cc26eb2711545c3,
title = "Beta-cell function and insulin sensitivity at various degrees of glucose tolerance in Chinese subjects",
abstract = "Aims: The aim of this study was to evaluate the relative importance of insulin sensitivity (SI), and the first (1st ISEC) and second phase insulin secretion (2nd ISEC) in the development of type 2 diabetes (T2D) in Chinese subjects. Methods: A total of 96 subjects, including 19 with normal fasting glucose, 21 with pre-diabetes, and 56 with T2D were enrolled. Subjects underwent a modified low dose graded glucose infusion (M-LDGGI; a simplified version of Polonsky's method) and frequently sampled intravenous glucose tolerance test. The results were interpreted as the slope of the changes of plasma insulin against the glucose levels. By observing the respective percentage reduction, the deterioration rate of each parameter was compared. Results: As fasting plasma glucose (FPG) levels increased, SI decreased mildly and non-significantly, while the 1st and 2nd ISECs decreased more dramatically and significantly. More importantly, the decrease of the 1st ISEC from baseline was greater than that of the 2nd ISEC. Conclusions: Since the 1st ISEC decreased the most with increasing FPG levels, it is concluded that the 1st ISEC is the key trigger of T2D development. On the contrary, the 2nd ISEC remained more stable across increasing FPG levels. This latter finding may explain the effectiveness of insulin secretagogues during the early stage of T2D. The results of this study can be helpful in the development of interventions aimed at stopping the progression and/or treating T2D in Chinese populations.",
keywords = "First phase insulin secretion, Second phase insulin secretion, Type 2 diabetes",
author = "Lin, {Jiunn Diann} and Chen, {Yen Lin} and Hsu, {Chun Hsien} and Wu, {Chung Ze} and An-Tsz Hsieh and Hsieh, {Chang Hsun} and Chang, {Jin Biou} and Liang, {Yao Jen} and Dee Pei",
year = "2013",
month = "6",
doi = "10.1016/j.diabres.2013.03.022",
language = "English",
volume = "100",
pages = "391--397",
journal = "Diabetes Research and Clinical Practice",
issn = "0168-8227",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Beta-cell function and insulin sensitivity at various degrees of glucose tolerance in Chinese subjects

AU - Lin, Jiunn Diann

AU - Chen, Yen Lin

AU - Hsu, Chun Hsien

AU - Wu, Chung Ze

AU - Hsieh, An-Tsz

AU - Hsieh, Chang Hsun

AU - Chang, Jin Biou

AU - Liang, Yao Jen

AU - Pei, Dee

PY - 2013/6

Y1 - 2013/6

N2 - Aims: The aim of this study was to evaluate the relative importance of insulin sensitivity (SI), and the first (1st ISEC) and second phase insulin secretion (2nd ISEC) in the development of type 2 diabetes (T2D) in Chinese subjects. Methods: A total of 96 subjects, including 19 with normal fasting glucose, 21 with pre-diabetes, and 56 with T2D were enrolled. Subjects underwent a modified low dose graded glucose infusion (M-LDGGI; a simplified version of Polonsky's method) and frequently sampled intravenous glucose tolerance test. The results were interpreted as the slope of the changes of plasma insulin against the glucose levels. By observing the respective percentage reduction, the deterioration rate of each parameter was compared. Results: As fasting plasma glucose (FPG) levels increased, SI decreased mildly and non-significantly, while the 1st and 2nd ISECs decreased more dramatically and significantly. More importantly, the decrease of the 1st ISEC from baseline was greater than that of the 2nd ISEC. Conclusions: Since the 1st ISEC decreased the most with increasing FPG levels, it is concluded that the 1st ISEC is the key trigger of T2D development. On the contrary, the 2nd ISEC remained more stable across increasing FPG levels. This latter finding may explain the effectiveness of insulin secretagogues during the early stage of T2D. The results of this study can be helpful in the development of interventions aimed at stopping the progression and/or treating T2D in Chinese populations.

AB - Aims: The aim of this study was to evaluate the relative importance of insulin sensitivity (SI), and the first (1st ISEC) and second phase insulin secretion (2nd ISEC) in the development of type 2 diabetes (T2D) in Chinese subjects. Methods: A total of 96 subjects, including 19 with normal fasting glucose, 21 with pre-diabetes, and 56 with T2D were enrolled. Subjects underwent a modified low dose graded glucose infusion (M-LDGGI; a simplified version of Polonsky's method) and frequently sampled intravenous glucose tolerance test. The results were interpreted as the slope of the changes of plasma insulin against the glucose levels. By observing the respective percentage reduction, the deterioration rate of each parameter was compared. Results: As fasting plasma glucose (FPG) levels increased, SI decreased mildly and non-significantly, while the 1st and 2nd ISECs decreased more dramatically and significantly. More importantly, the decrease of the 1st ISEC from baseline was greater than that of the 2nd ISEC. Conclusions: Since the 1st ISEC decreased the most with increasing FPG levels, it is concluded that the 1st ISEC is the key trigger of T2D development. On the contrary, the 2nd ISEC remained more stable across increasing FPG levels. This latter finding may explain the effectiveness of insulin secretagogues during the early stage of T2D. The results of this study can be helpful in the development of interventions aimed at stopping the progression and/or treating T2D in Chinese populations.

KW - First phase insulin secretion

KW - Second phase insulin secretion

KW - Type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=84878480966&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878480966&partnerID=8YFLogxK

U2 - 10.1016/j.diabres.2013.03.022

DO - 10.1016/j.diabres.2013.03.022

M3 - Article

VL - 100

SP - 391

EP - 397

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

SN - 0168-8227

IS - 3

ER -