Beta-band modulation in the human hippocampus during a conflict response task

Kuang Hsuan Chen, Angad S. Gogia, Austin M. Tang, Roberto Martin Del Campo-Vera, Rinu Sebastian, George Nune, Janeline Wong, Charles Y. Liu, Spencer Kellis, Brian Lee

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Objective. Identify the role of beta-band (13–30 Hz) power modulation in the human hippocampus during conflict processing. Approach. We investigated changes in the spectral power of the beta band (13–30 Hz) as measured by depth electrode leads in the hippocampus during a modified Stroop task in six patients with medically refractory epilepsy. Previous work done with direct electrophysiological recordings in humans has shown hippocampal theta-band (3–8 Hz) modulation during conflict processing. Local field potentials sampled at 2 k Hz were used for analysis and a non-parametric cluster-permutation t-test was used to identify the time period and frequency ranges of significant power change during cue processing (i.e. post-stimulus, pre-response). Main results. In five of the six patients, we observe a statistically significant increase in hippocampal beta-band power during successful conflict processing in the incongruent trial condition (cluster-based correction for multiple comparisons, p < 0.05). There was no significant beta-band power change observed during the cue-processing period of the congruent condition in the hippocampus of these patients. Significance. The beta-power changes during conflict processing represented here are consistent with previous studies suggesting that the hippocampus plays a role in conflict processing, but it is the first time that the beta band has been shown to be involved in humans with direct electrophysiological evidence. We propose that beta-band modulation plays a role in successful conflict detection and automatic response inhibition in the human hippocampus as studied during a conflict response task.

Original languageEnglish
Article number066003
JournalJournal of Neural Engineering
Volume17
Issue number6
DOIs
Publication statusPublished - Nov 2020
Externally publishedYes

Keywords

  • Beta-band
  • Hippocampus
  • Human
  • Modulation
  • Response conflict
  • Stereo EEG
  • Stroop task

ASJC Scopus subject areas

  • Biomedical Engineering
  • Cellular and Molecular Neuroscience

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