Abstract

Objectives. Benzydamine is a nonsteroidal anti-inflammatory agents agent with anti-inflammatory and local anesthesia properties that is available in the entire world as an oral spray for oral mucositis patients who are suffering from radiation effects. The effect of benzydamine on oral mucositis in vivo is well known; however, the effect of the drug on tracheal smooth muscle has rarely been explored. During administration of the benzydamine for oral symptoms, it might affect the trachea via oral intake or inhalation.

Methods. We examined the effectiveness of benzydamine on isolated rat tracheal smooth muscle. The following assessments of benzydamine were performed: effect on tracheal smooth muscle resting tension; effect on contraction caused by 10-6M methacholine as a parasympathetic mimetic; and effect of the drug on electrically induced tracheal smooth muscle contractions.

Results. Addition of methacholine to the incubation medium caused the trachea to contract in a dose-dependent manner. Addition of benzydamine at doses of 10-5M or above elicited a significant relaxation response to 10-6M methacho-line-induced contraction. Benzydamine could inhibit electrical field stimulation-induced spike contraction. It alone had a minimal effect on the basal tension of trachea as the concentration increased.

Conclusion. This study indicated that high concentrations of benzydamine might actually inhibit parasympathetic function of the trachea. Benzydamine might reduce asthma attacks in oral mucositis patients because it could inhibit para-sympathetic function and reduce methacholine-induced contraction of tracheal smooth muscle.

Original languageEnglish
Pages (from-to)65-68
Number of pages4
JournalClinical and Experimental Otorhinolaryngology
Volume8
Issue number1
DOIs
Publication statusPublished - Mar 1 2015

Fingerprint

Oral Sprays
Benzydamine
Smooth Muscle
Trachea
Stomatitis
Methacholine Chloride
Muscle Tonus
Radiation Effects
Non-Steroidal Anti-Inflammatory Agents
Local Anesthesia
Muscle Contraction
Pharmaceutical Preparations
Inhalation
Electric Stimulation
Oral Administration
Anti-Inflammatory Agents

Keywords

  • Anti-Inflammatory agents
  • Benzydamine
  • In vitro study
  • Non-Steroidal
  • Smooth muscle
  • Trachea

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery

Cite this

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title = "Benzydamine oral spray inhibiting parasympathetic function of tracheal smooth muscle",
abstract = "Objectives. Benzydamine is a nonsteroidal anti-inflammatory agents agent with anti-inflammatory and local anesthesia properties that is available in the entire world as an oral spray for oral mucositis patients who are suffering from radiation effects. The effect of benzydamine on oral mucositis in vivo is well known; however, the effect of the drug on tracheal smooth muscle has rarely been explored. During administration of the benzydamine for oral symptoms, it might affect the trachea via oral intake or inhalation.Methods. We examined the effectiveness of benzydamine on isolated rat tracheal smooth muscle. The following assessments of benzydamine were performed: effect on tracheal smooth muscle resting tension; effect on contraction caused by 10-6M methacholine as a parasympathetic mimetic; and effect of the drug on electrically induced tracheal smooth muscle contractions.Results. Addition of methacholine to the incubation medium caused the trachea to contract in a dose-dependent manner. Addition of benzydamine at doses of 10-5M or above elicited a significant relaxation response to 10-6M methacho-line-induced contraction. Benzydamine could inhibit electrical field stimulation-induced spike contraction. It alone had a minimal effect on the basal tension of trachea as the concentration increased.Conclusion. This study indicated that high concentrations of benzydamine might actually inhibit parasympathetic function of the trachea. Benzydamine might reduce asthma attacks in oral mucositis patients because it could inhibit para-sympathetic function and reduce methacholine-induced contraction of tracheal smooth muscle.",
keywords = "Anti-Inflammatory agents, Benzydamine, In vitro study, Non-Steroidal, Smooth muscle, Trachea",
author = "Wang, {Hsing Won} and Chao, {Pin Zhir} and Lee, {Fei Peng} and Wang, {Jia Yi}",
year = "2015",
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language = "English",
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T1 - Benzydamine oral spray inhibiting parasympathetic function of tracheal smooth muscle

AU - Wang, Hsing Won

AU - Chao, Pin Zhir

AU - Lee, Fei Peng

AU - Wang, Jia Yi

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N2 - Objectives. Benzydamine is a nonsteroidal anti-inflammatory agents agent with anti-inflammatory and local anesthesia properties that is available in the entire world as an oral spray for oral mucositis patients who are suffering from radiation effects. The effect of benzydamine on oral mucositis in vivo is well known; however, the effect of the drug on tracheal smooth muscle has rarely been explored. During administration of the benzydamine for oral symptoms, it might affect the trachea via oral intake or inhalation.Methods. We examined the effectiveness of benzydamine on isolated rat tracheal smooth muscle. The following assessments of benzydamine were performed: effect on tracheal smooth muscle resting tension; effect on contraction caused by 10-6M methacholine as a parasympathetic mimetic; and effect of the drug on electrically induced tracheal smooth muscle contractions.Results. Addition of methacholine to the incubation medium caused the trachea to contract in a dose-dependent manner. Addition of benzydamine at doses of 10-5M or above elicited a significant relaxation response to 10-6M methacho-line-induced contraction. Benzydamine could inhibit electrical field stimulation-induced spike contraction. It alone had a minimal effect on the basal tension of trachea as the concentration increased.Conclusion. This study indicated that high concentrations of benzydamine might actually inhibit parasympathetic function of the trachea. Benzydamine might reduce asthma attacks in oral mucositis patients because it could inhibit para-sympathetic function and reduce methacholine-induced contraction of tracheal smooth muscle.

AB - Objectives. Benzydamine is a nonsteroidal anti-inflammatory agents agent with anti-inflammatory and local anesthesia properties that is available in the entire world as an oral spray for oral mucositis patients who are suffering from radiation effects. The effect of benzydamine on oral mucositis in vivo is well known; however, the effect of the drug on tracheal smooth muscle has rarely been explored. During administration of the benzydamine for oral symptoms, it might affect the trachea via oral intake or inhalation.Methods. We examined the effectiveness of benzydamine on isolated rat tracheal smooth muscle. The following assessments of benzydamine were performed: effect on tracheal smooth muscle resting tension; effect on contraction caused by 10-6M methacholine as a parasympathetic mimetic; and effect of the drug on electrically induced tracheal smooth muscle contractions.Results. Addition of methacholine to the incubation medium caused the trachea to contract in a dose-dependent manner. Addition of benzydamine at doses of 10-5M or above elicited a significant relaxation response to 10-6M methacho-line-induced contraction. Benzydamine could inhibit electrical field stimulation-induced spike contraction. It alone had a minimal effect on the basal tension of trachea as the concentration increased.Conclusion. This study indicated that high concentrations of benzydamine might actually inhibit parasympathetic function of the trachea. Benzydamine might reduce asthma attacks in oral mucositis patients because it could inhibit para-sympathetic function and reduce methacholine-induced contraction of tracheal smooth muscle.

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