Beneficial effects of β-conglycinin on renal function and nephrin expression in early streptozotocin-induced diabetic nephropathy rats

Hsin Yi Yang, Lin Yi Wu, Wan Ju Yeh, Jiun-Rong Chen

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The objective of the present study was to investigate the effects of β-conglycinin and soya isoflavones on diabetic nephropathy (DN). DN was induced by an intravenous injection of streptozotocin (25mg/kg) in spontaneously hypertensive rats. DN rats were divided into a non-diabetic group (C, control group) and three DN groups (D, DN with control diet; B, DN+control diet with one-eighth of casein replaced by β-conglycinin as the protein source; and I, DN+control diet with 0·01% soya isoflavones). After a 4-week experimental period, we found that fasting blood sugar and plasma and kidney advanced glycation end product levels and 24h urinary protein excretion of the B group were significantly lower than those of the D group and insulin sensitivity and nephrin expression of the B group were significantly higher than those of the D group. In addition, systolic blood pressure, angiotensin-converting enzyme activity, angiotensin II level and plasma TAG level of the B group were significantly lower than those of the D group, whereas only the levels of plasma TAG and thiobarbituric acid-reactive substances of the I group were lower than those of the D group. In conclusion, β-conglycinin may be beneficial for retarding DN progression and this effect cannot be completely explained by its isoflavone content.

Original languageEnglish
Pages (from-to)78-85
Number of pages8
JournalBritish Journal of Nutrition
Volume111
Issue number1
DOIs
Publication statusPublished - Jan 14 2014

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Keywords

  • β-Conglycinin
  • Diabetes
  • Diabetic nephropathy
  • Hypertension
  • Nephrin
  • Soya

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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