Bayesian models for population-based case-control studies when the population is in Hardy-Weinberg equilibrium

K. F. Cheng, J. H. Chen

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Association analysis of genetic polymorphisms has been mostly performed in a case-control setting with unrelated affected subjects compared with unrelated unaffected subjects. In this paper, we present a Bayesian method for analyzing such case-control data when the population is in Hardy-Weinberg equilibrium. Our Bayesian method depends on the informative prior which is the retrospective likelihood based on historical data, raised to a power a. By modeling the retrospective likelihood properly, different prior information about the studied population can be incorporated into the specification of the prior. The scalar a is a precision parameter quantifying the heterogeneity between current and historical data. A guide value for a is discussed in this paper. The informative prior and posterior distributions are proper under very general conditions. Therefore, our method can be applied in most case-control studies. Further, for assessing gene-environment interactions, our approach will naturally lead to a Bayesian model depending only on the case data, when genotype and environmental factors are independent in the population. Thus our approach can be applied to case-only studies. A real example is used to show the applications of our method.

Original languageEnglish
Pages (from-to)183-192
Number of pages10
JournalGenetic Epidemiology
Volume28
Issue number2
DOIs
Publication statusPublished - Feb 2005
Externally publishedYes

Keywords

  • Bayesian
  • Case-control
  • Case-only design
  • Interaction
  • Odds ratios
  • Retrospective likelihood

ASJC Scopus subject areas

  • Genetics(clinical)
  • Epidemiology

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