Baicalin attenuates air embolism-induced acute lung injury in rat isolated lungs

Min Hui Li, Kun Lun Huang, Shu Yu Wu, Chien Wen Chen, Horng Chin Yan, Kang Hsu, Ching Wang Hsu, Shin Hung Tsai, Shi Jye Chu

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21 Citations (Scopus)

Abstract

Background and purpose: Baicalin has been reported to have anti-Inflammatory effects and protect against various tissue injuries. However, the effect of baicalin on air embolism-Induced acute lung injury has not been tested yet. Experimental approach: Acute lung injury was induced by infusion of air at a rate of 0.25 mL-min -1 for 1 mln Into the pulmonary artery of rat isolated lungs. At the end of the experiment, samples were collected for assessment of lung Injury, biochemical analysis and histology. Different doses of baicalin (1, 2 and 4 mg-kg -1) were given Into the perfusate before air infusion. Key results: Air embolism elicited a significant Increase in microvascular permeability (Kf), lung weight gain, wet/dry weight ratio, pulmonary artery pressure and protein concentration In the bronchoalveolar lavage fluid. Levels of the cytokines, tumour necrosis factor α and cytokine-induced neutrophil chemoattractant-1 In perfusate, and malondialdehyde levels and myeloperoxidase activities in lung tissue were also significantly increased. In addition, histological examination showed Increased neutrophil infiltration In lung tissues. Furthermore, nuclear factor-KB activity and degradation of kB-α were significantly increased in lungs. Pretreatment of the lungs with baicalin (4 mg-kg -1) showed a statistically significant difference In all of the assessed parameters, except for alteration in the pulmonary artery pressure. Conclusions and implications: Our study suggests that baicalin attenuated air embolism-Induced acute lung injury and may be considered a useful adjunct drug therapy in this clinical condition.

Original languageEnglish
Pages (from-to)244-251
Number of pages8
JournalBritish Journal of Pharmacology
Volume157
Issue number2
DOIs
Publication statusPublished - May 2009
Externally publishedYes

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Keywords

  • Acute lung injury
  • Air embolism
  • Baicalin

ASJC Scopus subject areas

  • Pharmacology

Cite this

Li, M. H., Huang, K. L., Wu, S. Y., Chen, C. W., Yan, H. C., Hsu, K., Hsu, C. W., Tsai, S. H., & Chu, S. J. (2009). Baicalin attenuates air embolism-induced acute lung injury in rat isolated lungs. British Journal of Pharmacology, 157(2), 244-251. https://doi.org/10.1111/j.1476-5381.2009.00139.x