Baicalein, an active component of Scutellaria baicalensis Georgi, improves cardiac contractile function in endotoxaemic rats via induction of heme oxygenase-1 and suppression of inflammatory responses

Yen Mei Lee, Pao Yun Cheng, Lih Shin Chim, Ching Wen Kung, Shuk Man Ka, Ming Tzeung Chung, Joen Rong Sheu

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Aim of the study: To evaluate the protective effect of baicalein on myocardial dysfunction caused by endotoxaemia in rats and to explore the possible mechanisms. Materials and methods: Baicalein (10 mg/kg, intravenous) was administered to conscious Wistar rats 30 min after lipopolysaccharide (LPS; 10 mg/kg, intravenous) challenge. Six hours after LPS administration, the contractile function of the isolated heart was examined using the Langendorff technique. Cardiac protein expression related to inflammatory responses, superoxide anion production and caspase-3 activity were measured. Results: Post-treatment with baicalein significantly attenuated the LPS-induced hypotension with accompanying tachycardia. The contractile function of isolated heart was significantly preserved 6 h after LPS administration, following treatment with baicalein. Furthermore, baicalein induced the expression of heme oxygenase-1 protein and reduced superoxide anion formation in the myocardium of LPS-treated rats. Cardiac levels of inducible nitric oxide synthase, monocyte chemoattractant protein-1, phospho-IκBα and phospho-p65 protein and caspase-3 activity significantly increased 6 h after LPS challenge but baicalein significantly attenuated these LPS-induced changes. Conclusions: Baicalein improves myocardial contractility in LPS-induced sepsis, which may be related to reductions in oxidative stress, myocardial inflammatory responses and apoptosis.

Original languageEnglish
Pages (from-to)179-185
Number of pages7
JournalJournal of Ethnopharmacology
Volume135
Issue number1
DOIs
Publication statusPublished - Apr 26 2011

Keywords

  • Apoptosis
  • Baicalein
  • Inflammation
  • Myocardial dysfunction
  • Oxidative stress
  • Sepsis

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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