Bacterial alterations in salivary microbiota and their association in oral cancer

Wei Hsiang Lee, Hui Mei Chen, Shun Fa Yang, Chao Liang, Chih Yu Peng, Feng Mao Lin, Lo Lin Tsai, Buor Chang Wu, Chung Han Hsin, Chun Yi Chuang, Ting Yang, Tzu Ling Yang, Shinn Ying Ho, Wen Liang Chen, Kwo Chang Ueng, Hsien Da Huang, Chien Ning Huang, Yuh Jyh Jong

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of the oral cavity and the fourth leading malignancy and cause of cancer-related death in the male population of Taiwan. Most cases are detected at advanced stages, resulting in poor prognosis. Therefore, improved detection of early oral health disorders is indispensable. The involvement of oral bacteria in inflammation and their association with OSCC progression provide a feasible target for diagnosis. Due to the nature of oral neoplasms, the diagnosis of epithelial precursor lesions is relatively easy compared with that of other types of cancer. However, the transition from an epithelial precursor lesion to cancer is slow and requires further and continuous follow-up. In this study, we investigated microbiota differences between normal individuals, epithelial precursor lesion patients, and cancer patients with different lifestyle habits, such as betel chewing and smoking, using next-generation sequencing. Overall, the oral microbiome compositions of five genera, Bacillus, Enterococcus, Parvimonas, Peptostreptococcus, and Slackia, revealed significant differences between epithelial precursor lesion and cancer patients and correlated with their classification into two clusters. These composition changes might have the potential to constitute a biomarker to help in monitoring the oral carcinogenesis transition from epithelial precursor lesion to cancer.

Original languageEnglish
Article number16540
JournalScientific Reports
Volume7
Issue number1
DOIs
Publication statusPublished - Dec 1 2017
Externally publishedYes

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Mouth Neoplasms
Microbiota
Neoplasms
Squamous Cell Carcinoma
Peptostreptococcus
Oral Diagnosis
Mastication
Enterococcus
Oral Health
Taiwan
Bacillus
Habits
Mouth
Life Style
Carcinogenesis
Biomarkers
Smoking
Inflammation
Bacteria
Population

ASJC Scopus subject areas

  • General

Cite this

Lee, W. H., Chen, H. M., Yang, S. F., Liang, C., Peng, C. Y., Lin, F. M., ... Jong, Y. J. (2017). Bacterial alterations in salivary microbiota and their association in oral cancer. Scientific Reports, 7(1), [16540]. https://doi.org/10.1038/s41598-017-16418-x

Bacterial alterations in salivary microbiota and their association in oral cancer. / Lee, Wei Hsiang; Chen, Hui Mei; Yang, Shun Fa; Liang, Chao; Peng, Chih Yu; Lin, Feng Mao; Tsai, Lo Lin; Wu, Buor Chang; Hsin, Chung Han; Chuang, Chun Yi; Yang, Ting; Yang, Tzu Ling; Ho, Shinn Ying; Chen, Wen Liang; Ueng, Kwo Chang; Huang, Hsien Da; Huang, Chien Ning; Jong, Yuh Jyh.

In: Scientific Reports, Vol. 7, No. 1, 16540, 01.12.2017.

Research output: Contribution to journalArticle

Lee, WH, Chen, HM, Yang, SF, Liang, C, Peng, CY, Lin, FM, Tsai, LL, Wu, BC, Hsin, CH, Chuang, CY, Yang, T, Yang, TL, Ho, SY, Chen, WL, Ueng, KC, Huang, HD, Huang, CN & Jong, YJ 2017, 'Bacterial alterations in salivary microbiota and their association in oral cancer', Scientific Reports, vol. 7, no. 1, 16540. https://doi.org/10.1038/s41598-017-16418-x
Lee, Wei Hsiang ; Chen, Hui Mei ; Yang, Shun Fa ; Liang, Chao ; Peng, Chih Yu ; Lin, Feng Mao ; Tsai, Lo Lin ; Wu, Buor Chang ; Hsin, Chung Han ; Chuang, Chun Yi ; Yang, Ting ; Yang, Tzu Ling ; Ho, Shinn Ying ; Chen, Wen Liang ; Ueng, Kwo Chang ; Huang, Hsien Da ; Huang, Chien Ning ; Jong, Yuh Jyh. / Bacterial alterations in salivary microbiota and their association in oral cancer. In: Scientific Reports. 2017 ; Vol. 7, No. 1.
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