Bacteremia in children with acute lymphoblastic leukemia.

S. H. Chen, D. C. Liang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Bacteremia is one of the important complications of the treatment of hematological malignancy. In this report, we analyze bacteremias in 72 children with acute lymphoblastic leukemia who were admitted to our hospital from July 1, 1988 to October 31, 1991. Positive blood cultures were found in 26% (19/72) of the patients. There were 24 episodes of bacteremia; Gram-negative, Gram-positive and mixed bacteremia comprised 62.5% (15/24), 33.3% (8/24) and 4.2% (1/24), respectively. E. coli, klebsiella pneumoniae and Pseudomonas aeruginosa were the three most common pathogens. Eighty-three percent of the bacteremic episodes occurred during neutropenia (absolute neutrophil count below 500/mm3). Our data suggest that a Pseudomonas etiology, associated pneumonia, and shock accounted for a poor outcome. The over-all mortality for bacteremic events was 26.3% (5/19). Intensive supportive treatment and effective antibiotics are the most important factors in improving the outcome of bacteremia. The success in recent ALL treatment can be attributed in part to the improved outcome of bacteremia.

Original languageEnglish
Pages (from-to)167-172
Number of pages6
JournalActa Paediatrica Sinica
Volume34
Issue number3
Publication statusPublished - May 1993
Externally publishedYes

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Bacteremia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Klebsiella pneumoniae
Hematologic Neoplasms
Pseudomonas
Neutropenia
Pseudomonas aeruginosa
Shock
Pneumonia
Neutrophils
Therapeutics
Escherichia coli
Anti-Bacterial Agents
Mortality

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Bacteremia in children with acute lymphoblastic leukemia. / Chen, S. H.; Liang, D. C.

In: Acta Paediatrica Sinica, Vol. 34, No. 3, 05.1993, p. 167-172.

Research output: Contribution to journalArticle

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