Bacteremia caused by Salmonella enterica serotype Choleraesuis in Taiwan

Shio Shin Jean, Jen Yu Wang, Po Ren Hsueh

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Since 1995, there has been a steady increase in the number of reported cases of Salmonella enterica serotype Choleraesuis (S. Choleraesuis) sepsis in Taiwan. Representative Taiwanese survey data from 1996 to 2004 revealed that these adult patients with S. Choleraesuis bacteremia presented with primary bacteremia (57%, especially immunocompromised hosts), mycotic aneurysm (16%), and fever (86%) predominantly. S. Choleraesuis septicemia demonstrated a higher invasion index (with secondary involved sites) than other Salmonella spp. In swine experiments, the inoculation dose of 10 3 colony forming units S. Choleraesuis was cleared without apparent sequelae. Transmission of specific strains (with mutations of GyrA and parC, subsequently resistance to fluoroquinolones) from swine, and the acquisition of genes (CMY-2, AmpC complex) encoding beta-lactamases (with resistance to extended-spectrum cephalosporins) have been implicated in the evolution of multiresistant phenotypes of S. Choleraesuis. The virulence plasmid of S. Choleraesuis (pSCV), and other genes mediating adhesion to the epithelial cell membrane of the gastrointestinal tract, were considered important pathogenic factors for S. Choleraesuis. Vaccines for domestic animals combined with effective controls on antibiotic use offer the greatest potential to control the increasing impact of S. Choleraesuis on humans.

Original languageEnglish
Pages (from-to)358-365
Number of pages8
JournalJournal of Microbiology, Immunology and Infection
Volume39
Issue number5
Publication statusPublished - Oct 2006
Externally publishedYes

Fingerprint

Salmonella enterica
Bacteremia
Taiwan
Sepsis
Swine
Infected Aneurysm
Serogroup
Fluoroquinolones
Domestic Animals
Immunocompromised Host
Cephalosporins
beta-Lactamases
Salmonella
Genes
Virulence
Gastrointestinal Tract
Plasmids
Fever
Stem Cells
Vaccines

Keywords

  • Beta-lactamases
  • Cephalosporins
  • Fluoroquinolones
  • Salmonella enterica
  • Vaccines

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology and Allergy
  • Immunology and Microbiology(all)

Cite this

Bacteremia caused by Salmonella enterica serotype Choleraesuis in Taiwan. / Jean, Shio Shin; Wang, Jen Yu; Hsueh, Po Ren.

In: Journal of Microbiology, Immunology and Infection, Vol. 39, No. 5, 10.2006, p. 358-365.

Research output: Contribution to journalArticle

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