Aza analogs of flavones as potential antimicrobial agents

Sahil Sharma, Vikas Thakur, Ritu Ojha, Abhishek Budhiraja, Kunal Nepali, Preet Mohinder Singh Bedi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In search for the new antimicrobial agents owing to drug resistant bacteria and fungi, a series of rationally designed aza analogs of flavones has been designed and synthesized. The design of the analogs involved incorporation of quinolone nucleus within the flavone framework keeping in view the antimicrobial potential of both the classes. The series of compounds was evaluated for the antibacterial and antifungal activity against 3 Gram negative bacterial strains; E. coli (MTCC 82), S. typhi (MTCC 1251), P. aeruginosa (MTCC 2642), 2 gram positive bacterial strains B. subtilis (MTCC 2451), S. aureus (MTCC 96) and 2 pathogenic fungal strains, C. albicans (MTCC 3018), C. tropicalis (MTCC). The results of the antimicrobial evaluation clearly indicated the influence of the electronic factors linked with the aryl ring at the 2nd position with compounds bearing methoxy substitutents exhibiting significant antimicrobial profile as compared to the compounds bearing deactivating groups. The influence of placement of bicyclic, heteroaryl and bicyclic heteroaryl ring at the 2 nd position of the analogs was also observed.

Original languageEnglish
Pages (from-to)327-334
Number of pages8
JournalLetters in Drug Design and Discovery
Volume10
Issue number4
DOIs
Publication statusPublished - May 1 2013
Externally publishedYes

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Keywords

  • Antibacterial
  • Antifungal
  • Antimicrobial activity
  • Flavones
  • Quinolones
  • Strains

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

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