Autophagy facilitates an IFN-γ response and signal transduction

Yu-Ping Chang, Chia-Ling Chen, Su-O. Chen, Yee-Shin Lin, Cheng-Chieh Tsai, Wei-Ching Huang, Chi-Yun Wang, Chia-Yuan Hsieh, Pui-Ching Choi, Chiou Feng Lin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Autophagy, that is directly triggered by invaded pathogens and indirectly triggered by IFN-γ, acts as a defense by mediating intracellular microbial recognition and clearance. In addition, autophagy contributes to inflammation by facilitating an IFN-γ response and signal transduction. For immune escape, downregulated autophagy may be a strategy used by microbes.

Original languageEnglish
Pages (from-to)888-894
Number of pages7
JournalMicrobes and Infection
Volume13
Issue number11
DOIs
Publication statusPublished - Oct 2011

Fingerprint

Autophagy
Signal Transduction
Down-Regulation
Inflammation

Keywords

  • Autophagy
  • IFN-γ
  • Immune escape
  • Inflammation
  • Microbe
  • Signal transduction

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Autophagy facilitates an IFN-γ response and signal transduction. / Chang, Yu-Ping; Chen, Chia-Ling; Chen, Su-O.; Lin, Yee-Shin; Tsai, Cheng-Chieh; Huang, Wei-Ching; Wang, Chi-Yun; Hsieh, Chia-Yuan; Choi, Pui-Ching; Lin, Chiou Feng.

In: Microbes and Infection, Vol. 13, No. 11, 10.2011, p. 888-894.

Research output: Contribution to journalArticle

Chang, Y-P, Chen, C-L, Chen, S-O, Lin, Y-S, Tsai, C-C, Huang, W-C, Wang, C-Y, Hsieh, C-Y, Choi, P-C & Lin, CF 2011, 'Autophagy facilitates an IFN-γ response and signal transduction', Microbes and Infection, vol. 13, no. 11, pp. 888-894. https://doi.org/10.1016/j.micinf.2011.05.008
Chang, Yu-Ping ; Chen, Chia-Ling ; Chen, Su-O. ; Lin, Yee-Shin ; Tsai, Cheng-Chieh ; Huang, Wei-Ching ; Wang, Chi-Yun ; Hsieh, Chia-Yuan ; Choi, Pui-Ching ; Lin, Chiou Feng. / Autophagy facilitates an IFN-γ response and signal transduction. In: Microbes and Infection. 2011 ; Vol. 13, No. 11. pp. 888-894.
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