Autophagy facilitates an IFN-γ response and signal transduction

Yu-Ping Chang, Chia-Ling Chen, Su-O. Chen, Yee-Shin Lin, Cheng-Chieh Tsai, Wei-Ching Huang, Chi-Yun Wang, Chia-Yuan Hsieh, Pui-Ching Choi, Chiou Feng Lin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Autophagy, that is directly triggered by invaded pathogens and indirectly triggered by IFN-γ, acts as a defense by mediating intracellular microbial recognition and clearance. In addition, autophagy contributes to inflammation by facilitating an IFN-γ response and signal transduction. For immune escape, downregulated autophagy may be a strategy used by microbes.

Original languageEnglish
Pages (from-to)888-894
Number of pages7
JournalMicrobes and Infection
Volume13
Issue number11
DOIs
Publication statusPublished - Oct 2011

Keywords

  • Autophagy
  • IFN-γ
  • Immune escape
  • Inflammation
  • Microbe
  • Signal transduction

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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  • Cite this

    Chang, Y-P., Chen, C-L., Chen, S-O., Lin, Y-S., Tsai, C-C., Huang, W-C., Wang, C-Y., Hsieh, C-Y., Choi, P-C., & Lin, C. F. (2011). Autophagy facilitates an IFN-γ response and signal transduction. Microbes and Infection, 13(11), 888-894. https://doi.org/10.1016/j.micinf.2011.05.008