Autophagic mechanism in anti-cancer immunity

Its pros and cons for cancer therapy

Ying Ying Li, Lynn G. Feun, Angkana Thongkum, Chiao Hui Tu, Shu Mei Chen, Medhi Wangpaichitr, Chunjing Wu, Macus T. Kuo, Niramol Savaraj

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Autophagy, a self-eating machinery, has been reported as an adaptive response to maintain metabolic homeostasis when cancer cells encounter stress. It has been appreciated that autophagy acts as a double-edge sword to decide the fate of cancer cells upon stress factors, molecular subtypes, and microenvironmental conditions. Currently, the majority of evidence support that autophagy in cancer cells is a vital mechanism bringing on resistance to current and prospective treatments, yet whether autophagy affects the anticancer immune response remains unclear and controversial. Accumulated studies have demonstrated that triggering autophagy is able to facilitate anticancer immunity due to an increase in immunogenicity, whereas other studies suggested that autophagy is likely to disarm anticancer immunity mediated by cytotoxic T cells and nature killer (NK) cells. Hence, this contradiction needs to be elucidated. In this review, we discuss the role of autophagy in cancer cells per se and in cancer microenvironment as well as its dual regulatory roles in immune surveillance through modulating presentation of tumor antigens, development of immune cells, and expression of immune checkpoints. We further focus on emerging roles of autophagy induced by current treatments and its impact on anticancer immune response, and illustrate the pros and cons of utilizing autophagy in cancer immunotherapy based on preclinical references.

Original languageEnglish
Article number1297
JournalInternational Journal of Molecular Sciences
Volume18
Issue number6
DOIs
Publication statusPublished - Jun 19 2017

Fingerprint

Autophagy
immunity
Immunity
therapy
cancer
Cells
Neoplasms
T-cells
Neoplasm Antigens
Therapeutics
Antigens
eating
Machinery
homeostasis
Tumors
machinery
antigens
surveillance
cells
encounters

Keywords

  • Anticancer immunity
  • Autophagy
  • Autophagy antagonist
  • Immunogenicity
  • Tumor microenvironment

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Autophagic mechanism in anti-cancer immunity : Its pros and cons for cancer therapy. / Li, Ying Ying; Feun, Lynn G.; Thongkum, Angkana; Tu, Chiao Hui; Chen, Shu Mei; Wangpaichitr, Medhi; Wu, Chunjing; Kuo, Macus T.; Savaraj, Niramol.

In: International Journal of Molecular Sciences, Vol. 18, No. 6, 1297, 19.06.2017.

Research output: Contribution to journalReview article

Li, YY, Feun, LG, Thongkum, A, Tu, CH, Chen, SM, Wangpaichitr, M, Wu, C, Kuo, MT & Savaraj, N 2017, 'Autophagic mechanism in anti-cancer immunity: Its pros and cons for cancer therapy', International Journal of Molecular Sciences, vol. 18, no. 6, 1297. https://doi.org/10.3390/ijms18061297
Li, Ying Ying ; Feun, Lynn G. ; Thongkum, Angkana ; Tu, Chiao Hui ; Chen, Shu Mei ; Wangpaichitr, Medhi ; Wu, Chunjing ; Kuo, Macus T. ; Savaraj, Niramol. / Autophagic mechanism in anti-cancer immunity : Its pros and cons for cancer therapy. In: International Journal of Molecular Sciences. 2017 ; Vol. 18, No. 6.
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