Autologous serum skin test and autologous whole blood injections to patients with chronic urticaria: A retrospective analysis

J. T P Tseng, Woan Ruoh Lee, Sheng Shan Lin, Chun Hung Hsu, Hung H. Yang, Kuo Hsien Wang, Hsiou Hsin Tsai, Tsung Hsien Tsai

Research output: Contribution to journalArticle

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Abstract

Background: Chronic urticaria (CU) is defined as widespread short-lived (<24 h) itching maculopapular skin lesions with or without angioedema for more than 6 weeks for which a predominant physical cause must be excluded. The autologous serum skin test (ASST) has been shown to result in immediate hypersensitivity-type skin reactions in a subpopulation of CU patients and autologous whole blood (AWB) injection has been used as one of treatment modalities. Objective: To evaluate the relationship of a panel of laboratory examinations to the positivity of ASST and to evaluate the efficacy of AWB injection in the treatment of ASST (+) and ASST (-) CU patients. Methods: A retrospective chart review was performed on CU patients who were subjected to ASST and received AWB injection therapy. We assessed the therapeutic effects of 8 weekly AWB injections in ASST (+) and ASST (-) CU patients by using urticaria activity score (UAS). Results: Thiry-seven patients were analysed. There was no significant differences in number of patients, sex distribution, age, smoking vs. non-smoking, exacerbation of uricarial symptoms due to stress, and UAS between ASST (+) and ASST (-) CU patients at baseline. All patients presented normal complete blood count/differential count, and ANA. Anti-microsomal antibody was positive in 3/15 (20.0%) ASST (+) patients and in 2/22 (9.0%) ASST (-) patients (P = 0.6). The 8-week course of AWB injection was well tolerated. ASST (+) patients, but not ASST (-) patients, showed significantly reduced CU activity. Conclusion: 8 of the 9 ASST (+) patients with CU responded to treatment with AWB injection. Only 2 of the 8 ASST (-) patients showed response to the treatment. Others were having no effects or exacerbation of the urticarial symptoms. Further studies utilizing larger number of patients, longer follow-up periods, and different amount of autologous serum injection may better define the clinical efficacy of autologous serum injection for the treatment of chronic urticaria with positive ASST.

Original languageEnglish
Pages (from-to)27-36
Number of pages10
JournalDermatologica Sinica
Volume27
Issue number1
Publication statusPublished - Mar 2009

Fingerprint

Urticaria
Skin Tests
Injections
Serum
Therapeutics
Immediate Hypersensitivity
Angioedema
Skin
Sex Distribution
Blood Cell Count
Therapeutic Uses
Pruritus

Keywords

  • Autologous serum skin test
  • Autologous whole blood injection
  • Chronic urticaria

ASJC Scopus subject areas

  • Dermatology

Cite this

Tseng, J. T. P., Lee, W. R., Lin, S. S., Hsu, C. H., Yang, H. H., Wang, K. H., ... Tsai, T. H. (2009). Autologous serum skin test and autologous whole blood injections to patients with chronic urticaria: A retrospective analysis. Dermatologica Sinica, 27(1), 27-36.

Autologous serum skin test and autologous whole blood injections to patients with chronic urticaria : A retrospective analysis. / Tseng, J. T P; Lee, Woan Ruoh; Lin, Sheng Shan; Hsu, Chun Hung; Yang, Hung H.; Wang, Kuo Hsien; Tsai, Hsiou Hsin; Tsai, Tsung Hsien.

In: Dermatologica Sinica, Vol. 27, No. 1, 03.2009, p. 27-36.

Research output: Contribution to journalArticle

Tseng, J. T P ; Lee, Woan Ruoh ; Lin, Sheng Shan ; Hsu, Chun Hung ; Yang, Hung H. ; Wang, Kuo Hsien ; Tsai, Hsiou Hsin ; Tsai, Tsung Hsien. / Autologous serum skin test and autologous whole blood injections to patients with chronic urticaria : A retrospective analysis. In: Dermatologica Sinica. 2009 ; Vol. 27, No. 1. pp. 27-36.
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abstract = "Background: Chronic urticaria (CU) is defined as widespread short-lived (<24 h) itching maculopapular skin lesions with or without angioedema for more than 6 weeks for which a predominant physical cause must be excluded. The autologous serum skin test (ASST) has been shown to result in immediate hypersensitivity-type skin reactions in a subpopulation of CU patients and autologous whole blood (AWB) injection has been used as one of treatment modalities. Objective: To evaluate the relationship of a panel of laboratory examinations to the positivity of ASST and to evaluate the efficacy of AWB injection in the treatment of ASST (+) and ASST (-) CU patients. Methods: A retrospective chart review was performed on CU patients who were subjected to ASST and received AWB injection therapy. We assessed the therapeutic effects of 8 weekly AWB injections in ASST (+) and ASST (-) CU patients by using urticaria activity score (UAS). Results: Thiry-seven patients were analysed. There was no significant differences in number of patients, sex distribution, age, smoking vs. non-smoking, exacerbation of uricarial symptoms due to stress, and UAS between ASST (+) and ASST (-) CU patients at baseline. All patients presented normal complete blood count/differential count, and ANA. Anti-microsomal antibody was positive in 3/15 (20.0{\%}) ASST (+) patients and in 2/22 (9.0{\%}) ASST (-) patients (P = 0.6). The 8-week course of AWB injection was well tolerated. ASST (+) patients, but not ASST (-) patients, showed significantly reduced CU activity. Conclusion: 8 of the 9 ASST (+) patients with CU responded to treatment with AWB injection. Only 2 of the 8 ASST (-) patients showed response to the treatment. Others were having no effects or exacerbation of the urticarial symptoms. Further studies utilizing larger number of patients, longer follow-up periods, and different amount of autologous serum injection may better define the clinical efficacy of autologous serum injection for the treatment of chronic urticaria with positive ASST.",
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AU - Tseng, J. T P

AU - Lee, Woan Ruoh

AU - Lin, Sheng Shan

AU - Hsu, Chun Hung

AU - Yang, Hung H.

AU - Wang, Kuo Hsien

AU - Tsai, Hsiou Hsin

AU - Tsai, Tsung Hsien

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N2 - Background: Chronic urticaria (CU) is defined as widespread short-lived (<24 h) itching maculopapular skin lesions with or without angioedema for more than 6 weeks for which a predominant physical cause must be excluded. The autologous serum skin test (ASST) has been shown to result in immediate hypersensitivity-type skin reactions in a subpopulation of CU patients and autologous whole blood (AWB) injection has been used as one of treatment modalities. Objective: To evaluate the relationship of a panel of laboratory examinations to the positivity of ASST and to evaluate the efficacy of AWB injection in the treatment of ASST (+) and ASST (-) CU patients. Methods: A retrospective chart review was performed on CU patients who were subjected to ASST and received AWB injection therapy. We assessed the therapeutic effects of 8 weekly AWB injections in ASST (+) and ASST (-) CU patients by using urticaria activity score (UAS). Results: Thiry-seven patients were analysed. There was no significant differences in number of patients, sex distribution, age, smoking vs. non-smoking, exacerbation of uricarial symptoms due to stress, and UAS between ASST (+) and ASST (-) CU patients at baseline. All patients presented normal complete blood count/differential count, and ANA. Anti-microsomal antibody was positive in 3/15 (20.0%) ASST (+) patients and in 2/22 (9.0%) ASST (-) patients (P = 0.6). The 8-week course of AWB injection was well tolerated. ASST (+) patients, but not ASST (-) patients, showed significantly reduced CU activity. Conclusion: 8 of the 9 ASST (+) patients with CU responded to treatment with AWB injection. Only 2 of the 8 ASST (-) patients showed response to the treatment. Others were having no effects or exacerbation of the urticarial symptoms. Further studies utilizing larger number of patients, longer follow-up periods, and different amount of autologous serum injection may better define the clinical efficacy of autologous serum injection for the treatment of chronic urticaria with positive ASST.

AB - Background: Chronic urticaria (CU) is defined as widespread short-lived (<24 h) itching maculopapular skin lesions with or without angioedema for more than 6 weeks for which a predominant physical cause must be excluded. The autologous serum skin test (ASST) has been shown to result in immediate hypersensitivity-type skin reactions in a subpopulation of CU patients and autologous whole blood (AWB) injection has been used as one of treatment modalities. Objective: To evaluate the relationship of a panel of laboratory examinations to the positivity of ASST and to evaluate the efficacy of AWB injection in the treatment of ASST (+) and ASST (-) CU patients. Methods: A retrospective chart review was performed on CU patients who were subjected to ASST and received AWB injection therapy. We assessed the therapeutic effects of 8 weekly AWB injections in ASST (+) and ASST (-) CU patients by using urticaria activity score (UAS). Results: Thiry-seven patients were analysed. There was no significant differences in number of patients, sex distribution, age, smoking vs. non-smoking, exacerbation of uricarial symptoms due to stress, and UAS between ASST (+) and ASST (-) CU patients at baseline. All patients presented normal complete blood count/differential count, and ANA. Anti-microsomal antibody was positive in 3/15 (20.0%) ASST (+) patients and in 2/22 (9.0%) ASST (-) patients (P = 0.6). The 8-week course of AWB injection was well tolerated. ASST (+) patients, but not ASST (-) patients, showed significantly reduced CU activity. Conclusion: 8 of the 9 ASST (+) patients with CU responded to treatment with AWB injection. Only 2 of the 8 ASST (-) patients showed response to the treatment. Others were having no effects or exacerbation of the urticarial symptoms. Further studies utilizing larger number of patients, longer follow-up periods, and different amount of autologous serum injection may better define the clinical efficacy of autologous serum injection for the treatment of chronic urticaria with positive ASST.

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