Autoimmunity in dengue virus infection

Chiou Feng Lin, Huan Yao Lei, Ching Chuan Lui, Hsiao Sheng Lui, Trai Ming Yeh, Shun Hua Chen, Yee Shin Lin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Dengue haemorrhagic fever (DHF) is a complicated disease associated with viral and immune pathogenesis. There is still no effective vaccine to prevent the progression of DHF because of its undefined pathogenic mechanisms. The generation of autoimmunity in dengue virus (DEN) infection has been implicated in dengue pathogenesis. Based on our previous studies showing antibodies (Abs) against DEN nonstructural protein 1 (NS1) cross-reacted with human platelets and endothelial cells, a mechanism of molecular mimicry may contribute to autoantibody (autoAb) production. Here, the generation of autoAbs against human endothelial cells in patients infected with different DEN serotypes is shown. The levels of autoAbs present in different disease stages of DHF and the induction of endothelial cell apoptosis by patient sera were also determined. The results suggest that autoimmune responses are implicated in dengue disease pathogenesis and cause concern in vaccine development.

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalDengue Bulletin
Volume28
Publication statusPublished - Dec 2004
Externally publishedYes

Fingerprint

Severe Dengue
Dengue Virus
Virus Diseases
Autoimmunity
Endothelial Cells
Dengue
Vaccines
Molecular Mimicry
Autoantibodies
Blood Platelets
Apoptosis
Antibodies
Serum
Proteins

Keywords

  • Autoantibody
  • Dengue haemorrhagic fever
  • Dengue virus serotype
  • Endothelial cells

ASJC Scopus subject areas

  • Virology

Cite this

Lin, C. F., Lei, H. Y., Lui, C. C., Lui, H. S., Yeh, T. M., Chen, S. H., & Lin, Y. S. (2004). Autoimmunity in dengue virus infection. Dengue Bulletin, 28, 51-57.

Autoimmunity in dengue virus infection. / Lin, Chiou Feng; Lei, Huan Yao; Lui, Ching Chuan; Lui, Hsiao Sheng; Yeh, Trai Ming; Chen, Shun Hua; Lin, Yee Shin.

In: Dengue Bulletin, Vol. 28, 12.2004, p. 51-57.

Research output: Contribution to journalArticle

Lin, CF, Lei, HY, Lui, CC, Lui, HS, Yeh, TM, Chen, SH & Lin, YS 2004, 'Autoimmunity in dengue virus infection', Dengue Bulletin, vol. 28, pp. 51-57.
Lin CF, Lei HY, Lui CC, Lui HS, Yeh TM, Chen SH et al. Autoimmunity in dengue virus infection. Dengue Bulletin. 2004 Dec;28:51-57.
Lin, Chiou Feng ; Lei, Huan Yao ; Lui, Ching Chuan ; Lui, Hsiao Sheng ; Yeh, Trai Ming ; Chen, Shun Hua ; Lin, Yee Shin. / Autoimmunity in dengue virus infection. In: Dengue Bulletin. 2004 ; Vol. 28. pp. 51-57.
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