Autoimmunity in dengue pathogenesis

Shu Wen Wan, Chiou Feng Lin, Trai Ming Yeh, Ching Chuan Liu, Hsiao Sheng Liu, Shuying Wang, Pin Ling, Robert Anderson, Huan Yao Lei, Yee Shin Lin

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Dengue is one of the most important vector-borne viral diseases. With climate change and the convenience of travel, dengue is spreading beyond its usual tropical and subtropical boundaries. Infection with dengue virus (DENV) causes diseases ranging widely in severity, from self-limited dengue fever to life-threatening dengue hemorrhagic fever and dengue shock syndrome. Vascular leakage, thrombocytopenia, and hemorrhage are the major clinical manifestations associated with severe DENV infection, yet the mechanisms remain unclear. Besides the direct effects of the virus, immunopathogenesis is also involved in the development of dengue disease. Antibody-dependent enhancement increases the efficiency of virus infection and may suppress type I interferon-mediated antiviral responses. Aberrant activation of T cells and overproduction of soluble factors cause an increase in vascular permeability. DENV-induced autoantibodies against endothelial cells, platelets, and coagulatory molecules lead to their abnormal activation or dysfunction. Molecular mimicry between DENV proteins and host proteins may explain the cross-reactivity of DENV-induced autoantibodies. Although no licensed dengue vaccine is yet available, several vaccine candidates are under development. For the development of a safe and effective dengue vaccine, the immunopathogenic complications of dengue disease need to be considered.

Original languageEnglish
Pages (from-to)3-11
Number of pages9
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Volume112
Issue number1
DOIs
Publication statusPublished - Jan 2013
Externally publishedYes

Keywords

  • Autoimmunity
  • Dengue
  • Immunopathogenesis

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Autoimmunity in dengue pathogenesis'. Together they form a unique fingerprint.

  • Cite this

    Wan, S. W., Lin, C. F., Yeh, T. M., Liu, C. C., Liu, H. S., Wang, S., Ling, P., Anderson, R., Lei, H. Y., & Lin, Y. S. (2013). Autoimmunity in dengue pathogenesis. Journal of the Formosan Medical Association = Taiwan yi zhi, 112(1), 3-11. https://doi.org/10.1016/j.jfma.2012.11.006