Autism spectrum disorder model mice

Focus on copy number variation and epigenetics

Nobuhiro Nakai, Susumu Otsuka, Jihwan Myung, Toru Takumi

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Autism spectrum disorder (ASD) is gathering concerns in socially developed countries. ASD is a neuropsychiatric disorder of genetic origin with high prevalence of 1%–2%. The patients with ASD characteristically show impaired social skills. Today, many genetic studies identify numerous susceptible genes and genetic loci associated with ASD. Although some genetic factors can lead to abnormal brain function linked to ASD phenotypes, the pathogenic mechanism of ASD is still unclear. Here, we discuss a new mouse model for ASD as an advanced tool to understand the mechanism of ASD.

Original languageEnglish
Pages (from-to)976-984
Number of pages9
JournalScience China Life Sciences
Volume58
Issue number10
DOIs
Publication statusPublished - Oct 1 2015
Externally publishedYes

Fingerprint

Epigenomics
epigenetics
Brain
Genes
animal models
Inborn Genetic Diseases
Genetic Loci
autism
Autism Spectrum Disorder
genetic disorders
Developed Countries
developed countries
phenotype
brain
Phenotype
loci
gene
genes

Keywords

  • ASD model mouse
  • copy number variations
  • DNA methylation
  • histone modification

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

Cite this

Autism spectrum disorder model mice : Focus on copy number variation and epigenetics. / Nakai, Nobuhiro; Otsuka, Susumu; Myung, Jihwan; Takumi, Toru.

In: Science China Life Sciences, Vol. 58, No. 10, 01.10.2015, p. 976-984.

Research output: Contribution to journalReview article

Nakai, Nobuhiro ; Otsuka, Susumu ; Myung, Jihwan ; Takumi, Toru. / Autism spectrum disorder model mice : Focus on copy number variation and epigenetics. In: Science China Life Sciences. 2015 ; Vol. 58, No. 10. pp. 976-984.
@article{0d08d91795e44545bd3b1dc050854755,
title = "Autism spectrum disorder model mice: Focus on copy number variation and epigenetics",
abstract = "Autism spectrum disorder (ASD) is gathering concerns in socially developed countries. ASD is a neuropsychiatric disorder of genetic origin with high prevalence of 1{\%}–2{\%}. The patients with ASD characteristically show impaired social skills. Today, many genetic studies identify numerous susceptible genes and genetic loci associated with ASD. Although some genetic factors can lead to abnormal brain function linked to ASD phenotypes, the pathogenic mechanism of ASD is still unclear. Here, we discuss a new mouse model for ASD as an advanced tool to understand the mechanism of ASD.",
keywords = "ASD model mouse, copy number variations, DNA methylation, histone modification",
author = "Nobuhiro Nakai and Susumu Otsuka and Jihwan Myung and Toru Takumi",
year = "2015",
month = "10",
day = "1",
doi = "10.1007/s11427-015-4891-7",
language = "English",
volume = "58",
pages = "976--984",
journal = "Science China Life Sciences",
issn = "1674-7305",
publisher = "Science in China Press",
number = "10",

}

TY - JOUR

T1 - Autism spectrum disorder model mice

T2 - Focus on copy number variation and epigenetics

AU - Nakai, Nobuhiro

AU - Otsuka, Susumu

AU - Myung, Jihwan

AU - Takumi, Toru

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Autism spectrum disorder (ASD) is gathering concerns in socially developed countries. ASD is a neuropsychiatric disorder of genetic origin with high prevalence of 1%–2%. The patients with ASD characteristically show impaired social skills. Today, many genetic studies identify numerous susceptible genes and genetic loci associated with ASD. Although some genetic factors can lead to abnormal brain function linked to ASD phenotypes, the pathogenic mechanism of ASD is still unclear. Here, we discuss a new mouse model for ASD as an advanced tool to understand the mechanism of ASD.

AB - Autism spectrum disorder (ASD) is gathering concerns in socially developed countries. ASD is a neuropsychiatric disorder of genetic origin with high prevalence of 1%–2%. The patients with ASD characteristically show impaired social skills. Today, many genetic studies identify numerous susceptible genes and genetic loci associated with ASD. Although some genetic factors can lead to abnormal brain function linked to ASD phenotypes, the pathogenic mechanism of ASD is still unclear. Here, we discuss a new mouse model for ASD as an advanced tool to understand the mechanism of ASD.

KW - ASD model mouse

KW - copy number variations

KW - DNA methylation

KW - histone modification

UR - http://www.scopus.com/inward/record.url?scp=84945443946&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84945443946&partnerID=8YFLogxK

U2 - 10.1007/s11427-015-4891-7

DO - 10.1007/s11427-015-4891-7

M3 - Review article

VL - 58

SP - 976

EP - 984

JO - Science China Life Sciences

JF - Science China Life Sciences

SN - 1674-7305

IS - 10

ER -