Autism spectrum disorder model mice: Focus on copy number variation and epigenetics

Nobuhiro Nakai, Susumu Otsuka, Jihwan Myung, Toru Takumi

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Autism spectrum disorder (ASD) is gathering concerns in socially developed countries. ASD is a neuropsychiatric disorder of genetic origin with high prevalence of 1%–2%. The patients with ASD characteristically show impaired social skills. Today, many genetic studies identify numerous susceptible genes and genetic loci associated with ASD. Although some genetic factors can lead to abnormal brain function linked to ASD phenotypes, the pathogenic mechanism of ASD is still unclear. Here, we discuss a new mouse model for ASD as an advanced tool to understand the mechanism of ASD.

Original languageEnglish
Pages (from-to)976-984
Number of pages9
JournalScience China Life Sciences
Volume58
Issue number10
DOIs
Publication statusPublished - Oct 1 2015
Externally publishedYes

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Keywords

  • ASD model mouse
  • copy number variations
  • DNA methylation
  • histone modification

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

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