Abstract
Preparation of a high-concentration Au nanoring (NR) water solution and its applications to the enhancement of image contrast in optical coherence tomography (OCT) and the generation of the photothermal effect in a bio-sample through localized surface plasmon (LSP) resonance are demonstrated. Au NRs are first fabricated on a sapphire substrate with colloidal lithography and secondary sputtering of Au, and then transferred into a water solution through a liftoff process. By controlling the NR geometry, the LSP dipole resonance wavelength in tissue can cover a spectral range of 1300nm for OCT scanning of deep tissue penetration. The extinction cross sections of the fabricated Au NRs in water are estimated to give levels of 10-10-10 - 9cm2 near their LSP resonance wavelengths. The fabricated Au NRs are then delivered into pig adipose samples for OCT scanning. It is observed that, when resonant Au NRs are delivered into such a sample, LSP resonance-induced Au NR absorption results in a photothermal effect, making the opaque pig adipose cells transparent. Also, the delivered Au NRs in the intercellular substance enhance the image contrast of OCT scanning through LSP resonance-enhanced scattering. By continuously OCT scanning a sample, both photothermal and image contrast enhancement effects are observed. However, by continually scanning a sample with a low scan frequency, only the image contrast enhancement effect is observed.
| Original language | English |
|---|---|
| Article number | 295102 |
| Journal | Nanotechnology |
| Volume | 21 |
| Issue number | 29 |
| DOIs | |
| Publication status | Published - Jul 14 2010 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Bioengineering
- Chemistry(all)
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering
- Electrical and Electronic Engineering
Cite this
Au nanorings for enhancing absorption and backscattering monitored with optical coherence tomography. / Tseng, Hung Yu; Lee, Cheng Kuang; Wu, Shou Yen; Chi, Ting Ta; Yang, Kai Min; Wang, Jyh Yang; Kiang, Yean Woei; Yang, C. C.; Tsai, Meng Tsan; Wu, Yang Che; Chou, Han Yi E.; Chiang, Chun Pin.
In: Nanotechnology, Vol. 21, No. 29, 295102, 14.07.2010.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Au nanorings for enhancing absorption and backscattering monitored with optical coherence tomography
AU - Tseng, Hung Yu
AU - Lee, Cheng Kuang
AU - Wu, Shou Yen
AU - Chi, Ting Ta
AU - Yang, Kai Min
AU - Wang, Jyh Yang
AU - Kiang, Yean Woei
AU - Yang, C. C.
AU - Tsai, Meng Tsan
AU - Wu, Yang Che
AU - Chou, Han Yi E.
AU - Chiang, Chun Pin
PY - 2010/7/14
Y1 - 2010/7/14
N2 - Preparation of a high-concentration Au nanoring (NR) water solution and its applications to the enhancement of image contrast in optical coherence tomography (OCT) and the generation of the photothermal effect in a bio-sample through localized surface plasmon (LSP) resonance are demonstrated. Au NRs are first fabricated on a sapphire substrate with colloidal lithography and secondary sputtering of Au, and then transferred into a water solution through a liftoff process. By controlling the NR geometry, the LSP dipole resonance wavelength in tissue can cover a spectral range of 1300nm for OCT scanning of deep tissue penetration. The extinction cross sections of the fabricated Au NRs in water are estimated to give levels of 10-10-10 - 9cm2 near their LSP resonance wavelengths. The fabricated Au NRs are then delivered into pig adipose samples for OCT scanning. It is observed that, when resonant Au NRs are delivered into such a sample, LSP resonance-induced Au NR absorption results in a photothermal effect, making the opaque pig adipose cells transparent. Also, the delivered Au NRs in the intercellular substance enhance the image contrast of OCT scanning through LSP resonance-enhanced scattering. By continuously OCT scanning a sample, both photothermal and image contrast enhancement effects are observed. However, by continually scanning a sample with a low scan frequency, only the image contrast enhancement effect is observed.
AB - Preparation of a high-concentration Au nanoring (NR) water solution and its applications to the enhancement of image contrast in optical coherence tomography (OCT) and the generation of the photothermal effect in a bio-sample through localized surface plasmon (LSP) resonance are demonstrated. Au NRs are first fabricated on a sapphire substrate with colloidal lithography and secondary sputtering of Au, and then transferred into a water solution through a liftoff process. By controlling the NR geometry, the LSP dipole resonance wavelength in tissue can cover a spectral range of 1300nm for OCT scanning of deep tissue penetration. The extinction cross sections of the fabricated Au NRs in water are estimated to give levels of 10-10-10 - 9cm2 near their LSP resonance wavelengths. The fabricated Au NRs are then delivered into pig adipose samples for OCT scanning. It is observed that, when resonant Au NRs are delivered into such a sample, LSP resonance-induced Au NR absorption results in a photothermal effect, making the opaque pig adipose cells transparent. Also, the delivered Au NRs in the intercellular substance enhance the image contrast of OCT scanning through LSP resonance-enhanced scattering. By continuously OCT scanning a sample, both photothermal and image contrast enhancement effects are observed. However, by continually scanning a sample with a low scan frequency, only the image contrast enhancement effect is observed.
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UR - http://www.scopus.com/inward/citedby.url?scp=77954421302&partnerID=8YFLogxK
U2 - 10.1088/0957-4484/21/29/295102
DO - 10.1088/0957-4484/21/29/295102
M3 - Article
VL - 21
JO - Nanotechnology
JF - Nanotechnology
SN - 0957-4484
IS - 29
M1 - 295102
ER -