Atypical Temporal Dynamics of Resting State Shapes Stimulus-Evoked Activity in Depression—An EEG Study on Rest–Stimulus Interaction

Annemnarie Wolff, Sara de la Salle, Alana Sorgini, Emma Lynn, Pierre Blier, Verner Knott, Georg Northoff

Research output: Contribution to journalArticle

Abstract

Major depressive disorder (MDD) is a complex psychiatric disorder characterized by changes in both resting state and stimulus-evoked activity. Whether resting state changes are carried over to stimulus-evoked activity, however, is unclear. We conducted a combined rest (3 min) and task (three-stimulus auditory oddball paradigm) EEG study in n=28 acute depressed MDD patients, comparing them with n=25 healthy participants. Our focus was on the temporal dynamics of both resting state and stimulus-evoked activity for which reason we measured peak frequency (PF), coefficient of variation (CV), Lempel-Ziv complexity (LZC), and trial-to-trial variability (TTV). Our main findings are: i) atypical temporal dynamics in resting state, specifically in the alpha and theta bands as measured by peak frequency (PF), coefficient of variation (CV) and power; ii) decreased reactivity to external deviant stimuli as measured by decreased changes in stimulus-evoked variance and complexity—TTV, LZC, and power and frequency sliding (FS and PS); iii) correlation of stimulus related measures (TTV, LZC, PS, and FS) with resting state measures. Together, our findings show that resting state dynamics alone are atypical in MDD and, even more important, strongly shapes the dynamics of subsequent stimulus-evoked activity. We thus conclude that MDD can be characterized by an atypical temporal dynamic of its rest–stimulus interaction; that, in turn, makes it difficult for depressed patients to react to relevant stimuli such as the deviant tone in our paradigm.

Original languageEnglish
Article number719
JournalFrontiers in Psychiatry
Volume10
DOIs
Publication statusPublished - Oct 15 2019

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Major Depressive Disorder
Electroencephalography
Psychiatry
Healthy Volunteers
Power (Psychology)

Keywords

  • alpha oscillations
  • Depression
  • EEG
  • Peak frequency
  • resting state
  • theta oscillations

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Atypical Temporal Dynamics of Resting State Shapes Stimulus-Evoked Activity in Depression—An EEG Study on Rest–Stimulus Interaction. / Wolff, Annemnarie; de la Salle, Sara; Sorgini, Alana; Lynn, Emma; Blier, Pierre; Knott, Verner; Northoff, Georg.

In: Frontiers in Psychiatry, Vol. 10, 719, 15.10.2019.

Research output: Contribution to journalArticle

Wolff, Annemnarie ; de la Salle, Sara ; Sorgini, Alana ; Lynn, Emma ; Blier, Pierre ; Knott, Verner ; Northoff, Georg. / Atypical Temporal Dynamics of Resting State Shapes Stimulus-Evoked Activity in Depression—An EEG Study on Rest–Stimulus Interaction. In: Frontiers in Psychiatry. 2019 ; Vol. 10.
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