Attenuation of neutrophil and endothelial activation by intravenous morphine in patients with acute myocardial infarction

Tzong Luen Wang, Hang Chang, Chi Ren Hung, Yung Zu Tseng

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To investigate the effects of morphine on neutrophil and endothelial activation, we measured serum levels of intercellular adhesion molecule-1 (ICAM-1), L-selectin, and neutrophil endopeptidase 24.11 (NEP) in 38 patients with acute myocardial infarction (group 1) and 16 control subjects (group 2). In group 1, all the patients underwent blood sampling at initial presentation and 10 minutes later. Twenty of them had 3 mg of morphine administered intravenously immediately after the first sampling (group 1A) and the other 18 after a second sampling (group lB). The serum levels of ICAM-1 and L- selectin were both significantly higher in groups 1A and 1B than in group 2. In group 1A, the ICAM-1 decreased significantly at second blood samplings (310 ± 28 vs 368 ± 30 ng/ml; p

Original languageEnglish
Pages (from-to)1532-1535
Number of pages4
JournalAmerican Journal of Cardiology
Issue number12
Publication statusPublished - Dec 15 1997
Externally publishedYes


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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