Attenuation of neutrophil and endothelial activation by intravenous morphine in patients with acute myocardial infarction

Tzong Luen Wang, Hang Chang, Chi Ren Hung, Yung Zu Tseng

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

To investigate the effects of morphine on neutrophil and endothelial activation, we measured serum levels of intercellular adhesion molecule-1 (ICAM-1), L-selectin, and neutrophil endopeptidase 24.11 (NEP) in 38 patients with acute myocardial infarction (group 1) and 16 control subjects (group 2). In group 1, all the patients underwent blood sampling at initial presentation and 10 minutes later. Twenty of them had 3 mg of morphine administered intravenously immediately after the first sampling (group 1A) and the other 18 after a second sampling (group lB). The serum levels of ICAM-1 and L- selectin were both significantly higher in groups 1A and 1B than in group 2. In group 1A, the ICAM-1 decreased significantly at second blood samplings (310 ± 28 vs 368 ± 30 ng/ml; p

Original languageEnglish
Pages (from-to)1532-1535
Number of pages4
JournalAmerican Journal of Cardiology
Volume80
Issue number12
DOIs
Publication statusPublished - Dec 15 1997
Externally publishedYes

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Neutrophil Activation
Intercellular Adhesion Molecule-1
Morphine
L-Selectin
Myocardial Infarction
Neprilysin
Serum
Neutrophils
Control Groups

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Attenuation of neutrophil and endothelial activation by intravenous morphine in patients with acute myocardial infarction. / Wang, Tzong Luen; Chang, Hang; Hung, Chi Ren; Tseng, Yung Zu.

In: American Journal of Cardiology, Vol. 80, No. 12, 15.12.1997, p. 1532-1535.

Research output: Contribution to journalArticle

Wang, Tzong Luen ; Chang, Hang ; Hung, Chi Ren ; Tseng, Yung Zu. / Attenuation of neutrophil and endothelial activation by intravenous morphine in patients with acute myocardial infarction. In: American Journal of Cardiology. 1997 ; Vol. 80, No. 12. pp. 1532-1535.
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