Attentional modulation of emotional stimulus processing: An fMRI study using emotional expectancy

Felix Bermpohl, Alvaro Pascual-Leone, Amir Amedi, Lotfi B. Merabet, Felipe Fregni, Nadine Gaab, David Alsop, Gottfried Schlaug, Georg Northoff

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

We used emotional expectancy to study attentional modulation in the processing of emotional stimuli. During functional magnetic resonance imaging (fMRI), volunteers saw emotional and neutral expectancy cues signaling the subsequent presentation of corresponding emotional or neutral pictorial stimuli. As a control, emotional and neutral pictures were presented without preceding expectancy cue, resulting in a 2 × 2 factorial design with the factors "expectancy" and "emotion." Statistical analysis revealed a significant positive interaction effect between these factors in the medial prefrontal cortex (MPFC, Brodmann area [BA] 9/10), amygdala, and dorsal midbrain. In all these regions, expectancy augmented the neural response to emotional but not to neutral pictures. Time course analysis of raw data suggests that this augmented activation was not preceded by baseline increases in MPFC and amygdala during the period of emotional expectancy. In a post-scanning session, the paradigm was presented for a second time to allow emotional intensity rating. Again, a significant interaction between expectancy and emotion was observed, with intensity ratings specifically enhanced in emotional photographs preceded by expectancy. There was a positive correlation between intensity ratings and blood oxygenation level-dependent (BOLD) signals in the left amygdala. We conclude that specific components of the emotion network show enhanced activation in response to emotional stimuli when these are preceded by expectancy. This enhancement effect is not present in neutral pictures and might parallel accentuated subjective feeling states.

Original languageEnglish
Pages (from-to)662-677
Number of pages16
JournalHuman Brain Mapping
Volume27
Issue number8
DOIs
Publication statusPublished - Aug 2006
Externally publishedYes

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Emotions
Amygdala
Magnetic Resonance Imaging
Cues
Mesencephalon
Prefrontal Cortex
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Keywords

  • Amygdala
  • Attention
  • Emotion
  • Functional magnetic resonance imaging
  • Medial prefrontal cortex

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Radiological and Ultrasound Technology

Cite this

Attentional modulation of emotional stimulus processing : An fMRI study using emotional expectancy. / Bermpohl, Felix; Pascual-Leone, Alvaro; Amedi, Amir; Merabet, Lotfi B.; Fregni, Felipe; Gaab, Nadine; Alsop, David; Schlaug, Gottfried; Northoff, Georg.

In: Human Brain Mapping, Vol. 27, No. 8, 08.2006, p. 662-677.

Research output: Contribution to journalArticle

Bermpohl, F, Pascual-Leone, A, Amedi, A, Merabet, LB, Fregni, F, Gaab, N, Alsop, D, Schlaug, G & Northoff, G 2006, 'Attentional modulation of emotional stimulus processing: An fMRI study using emotional expectancy', Human Brain Mapping, vol. 27, no. 8, pp. 662-677. https://doi.org/10.1002/hbm.20209
Bermpohl F, Pascual-Leone A, Amedi A, Merabet LB, Fregni F, Gaab N et al. Attentional modulation of emotional stimulus processing: An fMRI study using emotional expectancy. Human Brain Mapping. 2006 Aug;27(8):662-677. https://doi.org/10.1002/hbm.20209
Bermpohl, Felix ; Pascual-Leone, Alvaro ; Amedi, Amir ; Merabet, Lotfi B. ; Fregni, Felipe ; Gaab, Nadine ; Alsop, David ; Schlaug, Gottfried ; Northoff, Georg. / Attentional modulation of emotional stimulus processing : An fMRI study using emotional expectancy. In: Human Brain Mapping. 2006 ; Vol. 27, No. 8. pp. 662-677.
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