Atrial Fibrillation and Coronary Artery Disease as Risk Factors of Retinal Artery Occlusion

A Nationwide Population-Based Study

Ju Chuan Yen, Hsiu Li Lin, Chia An Hsu, Yu Chuan Li, Min-Huei Hsu

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We use Taiwanese national health insurance research database (NHIRD) to investigate whether thrombolism (carotid artery disease (CAD) as a surrogate) or embolism (atrial fibrillation (AF) as a surrogate) plays roles in later retinal artery occlusion (RAO) development and examine their relative weights. The relative risks of RAO between AF and CAD patients and controls were compared by estimating the crude hazard ratio with logistic regression. Kaplan-Meier analysis was used to calculate the cumulative incidence rates of developing RAO, and a log-rank test was used to analyze the differences between the survival curves. Separate Cox proportional hazard regressions were done to compute the RAO-free rate after adjusting for possible confounding factors such as age and sex. The crude hazard ratios were 7.98 for the AF group and 5.27 for the CAD group, and the adjusted hazard ratios were 8.32 and 5.34 for the AF and CAD groups, respectively. The observation time with RAO-free was shorter for AF compared with CAD group (1490 versus 1819 days). AF and CAD were both risk factors for RAO with different hazard ratios. To tackle both AF and CAD is crucial for curbing RAO.

Original languageEnglish
Article number374616
JournalBioMed Research International
Volume2015
DOIs
Publication statusPublished - 2015
Externally publishedYes

Fingerprint

Retinal Artery Occlusion
Carotid Artery Diseases
Atrial Fibrillation
Coronary Artery Disease
Hazards
Population
Health insurance
Kaplan-Meier Estimate
National Health Programs
Embolism
Logistics
Logistic Models
Observation
Databases
Weights and Measures
Survival
Incidence
Research

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Atrial Fibrillation and Coronary Artery Disease as Risk Factors of Retinal Artery Occlusion : A Nationwide Population-Based Study. / Yen, Ju Chuan; Lin, Hsiu Li; Hsu, Chia An; Li, Yu Chuan; Hsu, Min-Huei.

In: BioMed Research International, Vol. 2015, 374616, 2015.

Research output: Contribution to journalArticle

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