ATP-binding cassette transporter A1 gene I823M polymorphism affects plasma high-density lipoprotein cholesterol level and modifies the effect of low high-density lipoprotein cholesterol on the risk of coronary artery disease

Chia Ti Tsai, Juey Jen Hwang, Fu Tien Chiang, Chuen Den Tseng, Jiunn Lee Lin, Yung Zu Tseng, Ling Ping Lai

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: TheI823M polymorphism of the ATP-binding cassette transporter A1 (ABCA1) gene has been reported to affect plasmahigh-density lipoprotein cholesterol (HDL-C) level. Information about its relationship to coronary artery disease (CAD) is limited. Methods and Results: We included 205 patients with angiographically documented CAD and 201 controls from the general population. We found thatI823M polymorphism was a significant source of variation of HDL-C (p = 0.024 after adjustment for age, sex, body mass index, smoking and alcohol drinking). Subjects with M823/M823 homozygotes (n = 103) had a higher HDL-C than those with I823/I823 or I823/M823 genotype (n = 98) (50.5 ± 9.7 vs. 47.6 ± 10.1 mg/dl, p = 0.039). I823M polymorphism was not a predictor of CAD in multivariate analysis (adjusted odds ratio = 1.5 [0.9-2.5], p = 0.145). However, it interacted with low HDL-C level to increase the risk of CAD. The odds ratio of CAD with M823 homozygosity was 5.3 (2.0-20.0) in patients with HDL-C ≤35 mg/dl, but was only 1.0 (0.5-2.0) in those with HDL >40 mg/dl (p = 0.039 for interaction). Conclusions: M823 variant of the ABCA1 gene was associated with a higher HDL-C. Furthermore, I823M polymorphism interacted with low-HDL-C on the risk of CAD. It served as a marker to identify high-risk patients for CAD in subjects with low-HDL-C.

Original languageEnglish
Pages (from-to)321-328
Number of pages8
JournalCardiology
Volume107
Issue number4
DOIs
Publication statusPublished - May 1 2007
Externally publishedYes

Keywords

  • ATP-binding cassette transporter 1
  • Coronary artery disease
  • Genetics
  • High-density lipoprotein cholesterol
  • Polymorphism

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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