Atopic dermatitis and risk of ischemic stroke: A nationwide population-based study

Vincent Yi Fong Su, Tzeng Ji Chen, Chiu Mei Yeh, Kun Ta Chou, Man Hsin Hung, Szu Ying Chu, Kang Cheng Su, Yu Sheng Chang, Ya Hsuan Lin, Chia Jen Liu

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Background. Epidemiological studies have shown a strong association between systemic inflammatory diseases, particularly allergic diseases, and cardiovascular diseases. However, the relationship between atopic dermatitis (AD) and ischemic stroke remains unclear. Method. The study identified 20,323 AD patients and 20,323 comorbidity-matched subjects between 2005 and 2008. The two cohorts were followed until 31 December 2009. Ischemic stroke and other cardiovascular events were determined. Results. During the follow-up period, 301 (1.48%) patients in the AD cohort and 228 (1.12%) matched subjects experienced ischemic stroke. After multivariate adjustment, patients with AD had a 1.33-fold (95% confidence interval (CI), 1.12-1.59; P = 0.001) increased incidence of ischemic stroke. Adjusted hazard ratios for the risk of ischemic stroke in patients with mild, moderate, and severe AD were 1.20 (95% CI, 1.00-1.45; P = 0.052), 1.64 (95% CI, 1.23-2.19; P = 0.001), and 1.71 (95% CI, 1.15-2.56; P = 0.008), respectively. The log-rank test showed a higher cumulative incidence of ischemic stroke in the severe AD group than in the moderate and mild AD groups during the follow-up period (P <0.001). Conclusions. AD may be an independent risk factor for ischemic stroke, and risk of ischemic stroke increases with AD severity.

Original languageEnglish
Pages (from-to)84-89
Number of pages6
JournalAnnals of Medicine
Volume46
Issue number2
DOIs
Publication statusPublished - Mar 2014

Fingerprint

Atopic Dermatitis
Stroke
Population
Confidence Intervals
Incidence
Comorbidity
Epidemiologic Studies
Cardiovascular Diseases
Odds Ratio
Myocardial Infarction

Keywords

  • Atopic dermatitis
  • Cardiovascular disease
  • Ischemic stroke

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Su, V. Y. F., Chen, T. J., Yeh, C. M., Chou, K. T., Hung, M. H., Chu, S. Y., ... Liu, C. J. (2014). Atopic dermatitis and risk of ischemic stroke: A nationwide population-based study. Annals of Medicine, 46(2), 84-89. https://doi.org/10.3109/07853890.2013.870018

Atopic dermatitis and risk of ischemic stroke : A nationwide population-based study. / Su, Vincent Yi Fong; Chen, Tzeng Ji; Yeh, Chiu Mei; Chou, Kun Ta; Hung, Man Hsin; Chu, Szu Ying; Su, Kang Cheng; Chang, Yu Sheng; Lin, Ya Hsuan; Liu, Chia Jen.

In: Annals of Medicine, Vol. 46, No. 2, 03.2014, p. 84-89.

Research output: Contribution to journalArticle

Su, VYF, Chen, TJ, Yeh, CM, Chou, KT, Hung, MH, Chu, SY, Su, KC, Chang, YS, Lin, YH & Liu, CJ 2014, 'Atopic dermatitis and risk of ischemic stroke: A nationwide population-based study', Annals of Medicine, vol. 46, no. 2, pp. 84-89. https://doi.org/10.3109/07853890.2013.870018
Su, Vincent Yi Fong ; Chen, Tzeng Ji ; Yeh, Chiu Mei ; Chou, Kun Ta ; Hung, Man Hsin ; Chu, Szu Ying ; Su, Kang Cheng ; Chang, Yu Sheng ; Lin, Ya Hsuan ; Liu, Chia Jen. / Atopic dermatitis and risk of ischemic stroke : A nationwide population-based study. In: Annals of Medicine. 2014 ; Vol. 46, No. 2. pp. 84-89.
@article{88d4b848426f4bfd8ee628b66dadf50c,
title = "Atopic dermatitis and risk of ischemic stroke: A nationwide population-based study",
abstract = "Background. Epidemiological studies have shown a strong association between systemic inflammatory diseases, particularly allergic diseases, and cardiovascular diseases. However, the relationship between atopic dermatitis (AD) and ischemic stroke remains unclear. Method. The study identified 20,323 AD patients and 20,323 comorbidity-matched subjects between 2005 and 2008. The two cohorts were followed until 31 December 2009. Ischemic stroke and other cardiovascular events were determined. Results. During the follow-up period, 301 (1.48{\%}) patients in the AD cohort and 228 (1.12{\%}) matched subjects experienced ischemic stroke. After multivariate adjustment, patients with AD had a 1.33-fold (95{\%} confidence interval (CI), 1.12-1.59; P = 0.001) increased incidence of ischemic stroke. Adjusted hazard ratios for the risk of ischemic stroke in patients with mild, moderate, and severe AD were 1.20 (95{\%} CI, 1.00-1.45; P = 0.052), 1.64 (95{\%} CI, 1.23-2.19; P = 0.001), and 1.71 (95{\%} CI, 1.15-2.56; P = 0.008), respectively. The log-rank test showed a higher cumulative incidence of ischemic stroke in the severe AD group than in the moderate and mild AD groups during the follow-up period (P <0.001). Conclusions. AD may be an independent risk factor for ischemic stroke, and risk of ischemic stroke increases with AD severity.",
keywords = "Atopic dermatitis, Cardiovascular disease, Ischemic stroke",
author = "Su, {Vincent Yi Fong} and Chen, {Tzeng Ji} and Yeh, {Chiu Mei} and Chou, {Kun Ta} and Hung, {Man Hsin} and Chu, {Szu Ying} and Su, {Kang Cheng} and Chang, {Yu Sheng} and Lin, {Ya Hsuan} and Liu, {Chia Jen}",
year = "2014",
month = "3",
doi = "10.3109/07853890.2013.870018",
language = "English",
volume = "46",
pages = "84--89",
journal = "Annals of Medicine",
issn = "0785-3890",
publisher = "Informa Healthcare",
number = "2",

}

TY - JOUR

T1 - Atopic dermatitis and risk of ischemic stroke

T2 - A nationwide population-based study

AU - Su, Vincent Yi Fong

AU - Chen, Tzeng Ji

AU - Yeh, Chiu Mei

AU - Chou, Kun Ta

AU - Hung, Man Hsin

AU - Chu, Szu Ying

AU - Su, Kang Cheng

AU - Chang, Yu Sheng

AU - Lin, Ya Hsuan

AU - Liu, Chia Jen

PY - 2014/3

Y1 - 2014/3

N2 - Background. Epidemiological studies have shown a strong association between systemic inflammatory diseases, particularly allergic diseases, and cardiovascular diseases. However, the relationship between atopic dermatitis (AD) and ischemic stroke remains unclear. Method. The study identified 20,323 AD patients and 20,323 comorbidity-matched subjects between 2005 and 2008. The two cohorts were followed until 31 December 2009. Ischemic stroke and other cardiovascular events were determined. Results. During the follow-up period, 301 (1.48%) patients in the AD cohort and 228 (1.12%) matched subjects experienced ischemic stroke. After multivariate adjustment, patients with AD had a 1.33-fold (95% confidence interval (CI), 1.12-1.59; P = 0.001) increased incidence of ischemic stroke. Adjusted hazard ratios for the risk of ischemic stroke in patients with mild, moderate, and severe AD were 1.20 (95% CI, 1.00-1.45; P = 0.052), 1.64 (95% CI, 1.23-2.19; P = 0.001), and 1.71 (95% CI, 1.15-2.56; P = 0.008), respectively. The log-rank test showed a higher cumulative incidence of ischemic stroke in the severe AD group than in the moderate and mild AD groups during the follow-up period (P <0.001). Conclusions. AD may be an independent risk factor for ischemic stroke, and risk of ischemic stroke increases with AD severity.

AB - Background. Epidemiological studies have shown a strong association between systemic inflammatory diseases, particularly allergic diseases, and cardiovascular diseases. However, the relationship between atopic dermatitis (AD) and ischemic stroke remains unclear. Method. The study identified 20,323 AD patients and 20,323 comorbidity-matched subjects between 2005 and 2008. The two cohorts were followed until 31 December 2009. Ischemic stroke and other cardiovascular events were determined. Results. During the follow-up period, 301 (1.48%) patients in the AD cohort and 228 (1.12%) matched subjects experienced ischemic stroke. After multivariate adjustment, patients with AD had a 1.33-fold (95% confidence interval (CI), 1.12-1.59; P = 0.001) increased incidence of ischemic stroke. Adjusted hazard ratios for the risk of ischemic stroke in patients with mild, moderate, and severe AD were 1.20 (95% CI, 1.00-1.45; P = 0.052), 1.64 (95% CI, 1.23-2.19; P = 0.001), and 1.71 (95% CI, 1.15-2.56; P = 0.008), respectively. The log-rank test showed a higher cumulative incidence of ischemic stroke in the severe AD group than in the moderate and mild AD groups during the follow-up period (P <0.001). Conclusions. AD may be an independent risk factor for ischemic stroke, and risk of ischemic stroke increases with AD severity.

KW - Atopic dermatitis

KW - Cardiovascular disease

KW - Ischemic stroke

UR - http://www.scopus.com/inward/record.url?scp=84893309058&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893309058&partnerID=8YFLogxK

U2 - 10.3109/07853890.2013.870018

DO - 10.3109/07853890.2013.870018

M3 - Article

C2 - 24460466

AN - SCOPUS:84893309058

VL - 46

SP - 84

EP - 89

JO - Annals of Medicine

JF - Annals of Medicine

SN - 0785-3890

IS - 2

ER -