Atherogenicity and carcinogenicity of high-arsenic artesian well water. Multiple risk factors and related malignant neoplasms of blackfoot disease

C. J. Chen, M. M. Wu, S. S. Lee, J. D. Wang, S. H. Cheng, H. Y. Wu

Research output: Contribution to journalArticle

245 Citations (Scopus)

Abstract

The objective of this study was to examine multiple risk factors and correlated malignant neoplasms of blackfoot disease (BFD), a unique peripheral vascular disease related to continuous exposure to high-arsenic artesian well water. A total of 241 BFD cases, including 169 with spontaneous or surgical amputations of affected extremities, and 759 age-sex-residence-matched healthy community controls were studied to explore the risk factors of BFD. Multiple logistic regression analysis showed that artesian well water consumption, arsenic poisoning, familial history of BFD, and undernourishment were significantly associated with the development of BFD. The lift-table method used to analyze cancer mortality of 789 BFD patients followed for 15 years showed a significantly higher mortality from cardiovascular diseases, peripheral vascular diseases, and cancers of bladder, skin, lung, and liver among BFD patients as compared with the general population in Taiwan or residents in the BFD-endemic area. The results imply the atherogenicity and carcinogenicity of the artesian well water in the BFD-endemic area.

Original languageEnglish
Pages (from-to)452-460
Number of pages9
JournalArteriosclerosis
Volume8
Issue number5
Publication statusPublished - Jan 1 1988
Externally publishedYes

Fingerprint

Water Wells
Arsenic
Water
Neoplasms
Endemic Diseases
Peripheral Vascular Diseases
Arsenic Poisoning
Mortality
Skin Neoplasms
Taiwan
Amputation
Urinary Bladder Neoplasms
Drinking
Cardiovascular Diseases
Extremities
Logistic Models
Regression Analysis
Lung
Liver

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Atherogenicity and carcinogenicity of high-arsenic artesian well water. Multiple risk factors and related malignant neoplasms of blackfoot disease. / Chen, C. J.; Wu, M. M.; Lee, S. S.; Wang, J. D.; Cheng, S. H.; Wu, H. Y.

In: Arteriosclerosis, Vol. 8, No. 5, 01.01.1988, p. 452-460.

Research output: Contribution to journalArticle

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AB - The objective of this study was to examine multiple risk factors and correlated malignant neoplasms of blackfoot disease (BFD), a unique peripheral vascular disease related to continuous exposure to high-arsenic artesian well water. A total of 241 BFD cases, including 169 with spontaneous or surgical amputations of affected extremities, and 759 age-sex-residence-matched healthy community controls were studied to explore the risk factors of BFD. Multiple logistic regression analysis showed that artesian well water consumption, arsenic poisoning, familial history of BFD, and undernourishment were significantly associated with the development of BFD. The lift-table method used to analyze cancer mortality of 789 BFD patients followed for 15 years showed a significantly higher mortality from cardiovascular diseases, peripheral vascular diseases, and cancers of bladder, skin, lung, and liver among BFD patients as compared with the general population in Taiwan or residents in the BFD-endemic area. The results imply the atherogenicity and carcinogenicity of the artesian well water in the BFD-endemic area.

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