Astragaloside improves outcomes of traumatic brain injury in rats by reducing microglia activation

Shun Tai Yang, Jia Wei Lin, Bi Ying Chiu, Yao Chin Hsu, Ching Ping Chang, Cheng Kuei Chang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Astragaloside (AST) is traditionally prescribed for the prevention and treatment of cerebrovascular diseases. We directly tested the therapeutic effects of AST in a rat model of traumatic brain injury (TBI). One hour after the onset of TBI rats were given Saline (1 ml/kg) or AST (20-80 mg/kg) via i.p. injection. AST causes the attenuation of TBI-induced cerebral contusion, neuronal apoptosis, and neurological motor dysfunction. TBI-induced microglial activation evidenced by the morphological transformation of microglia (or ameboid microglia) and the microglial overexpression of tumor necrosis factor-alpha was reduced by AST. Our results indicate that AST may protect against brain contusion and neuronal apoptosis after TBI by attenuating microglia activation in male rats.

Original languageEnglish
Pages (from-to)1357-1370
Number of pages14
JournalAmerican Journal of Chinese Medicine
Volume42
Issue number6
DOIs
Publication statusPublished - May 16 2014

Keywords

  • Astragaloside
  • Microglia
  • Traumatic Brain Injury
  • Tumor Necrosis Factor-Alpha

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Medicine(all)

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