Associations of Rsf-1 overexpression with poor therapeutic response and worse survival in patients with nasopharyngeal carcinoma

Hui Chun Tai, Hsuan Ying Huang, Sung Wei Lee, Ching Yih Lin, Ming Jen Sheu, Shih Lun Chang, Li Ching Wu, Yow Ling Shiue, Wen Ren Wu, Chun Mao Lin, Chien Feng Li

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Aims: Deregulated chromatin remodelling often leads to aberrant gene expression in cells, thereby implicating tumour development and progression. As a subunit of remodelling and spacing factor complex, Rsf-1 (HBXAP), a novel nuclear protein with histone chaperon function, mediates ATPase-dependent chromatin remodelling and confers tumour aggressiveness in common carcinomas. However, the expression of Rsf-1 has never been reported in nasopharyngeal carcinoma (NPC). This study aimed at evaluating the expression status, associations with clincopathological variables and prognostic implications of Rsf-1 in a well-defined cohort of NPC. Methods: Rsf-1 immunoexpression was retrospectively assessed in biopsies of 108 consecutive NPC patients without initial distant metastasis and treated with consistent guidelines. The results were correlated with the clinicopathological features, therapeutic response, local recurrence-free survival (LRFS), distant metastasis-free survival (DMFS) and disease-specific survival (DSS). Results: Present in 49 cases (45%), Rsf-1 overexpression was associated with N2,3 status (p=0.016), American Joint Committee on Cancer stage 3, 4 (p=0.004), and incomplete therapeutic response (p=0.041). In multivariate analyses, Rsf-1 overexpression not only emerged as the sole independent adverse prognosticator for LRFS (p=0.0002, RR 5.287) but also independently predicted worse DMFS (p=0.0011, RR 3.185) and DSS (p3,4 (p=0.0454) and N 2,3 (p=0.0319), respectively. Conclusion: Rsf-1 overexpression is common and is associated with adverse prognosticators and therapeutic response, which confers tumour aggressiveness through chromatin remodelling, and represents a potential prognostic biomarker in NPC.

Original languageEnglish
Pages (from-to)248-253
Number of pages6
JournalJournal of Clinical Pathology
Volume65
Issue number3
DOIs
Publication statusPublished - Mar 2012

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Chromatin Assembly and Disassembly
Survival
Neoplasm Metastasis
Neoplasms
Histone Chaperones
Therapeutics
Recurrence
Nuclear Proteins
Disease-Free Survival
Adenosine Triphosphatases
Multivariate Analysis
Biomarkers
Nasopharyngeal carcinoma
Guidelines
Carcinoma
Biopsy
Gene Expression

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Associations of Rsf-1 overexpression with poor therapeutic response and worse survival in patients with nasopharyngeal carcinoma. / Tai, Hui Chun; Huang, Hsuan Ying; Lee, Sung Wei; Lin, Ching Yih; Sheu, Ming Jen; Chang, Shih Lun; Wu, Li Ching; Shiue, Yow Ling; Wu, Wen Ren; Lin, Chun Mao; Li, Chien Feng.

In: Journal of Clinical Pathology, Vol. 65, No. 3, 03.2012, p. 248-253.

Research output: Contribution to journalArticle

Tai, Hui Chun ; Huang, Hsuan Ying ; Lee, Sung Wei ; Lin, Ching Yih ; Sheu, Ming Jen ; Chang, Shih Lun ; Wu, Li Ching ; Shiue, Yow Ling ; Wu, Wen Ren ; Lin, Chun Mao ; Li, Chien Feng. / Associations of Rsf-1 overexpression with poor therapeutic response and worse survival in patients with nasopharyngeal carcinoma. In: Journal of Clinical Pathology. 2012 ; Vol. 65, No. 3. pp. 248-253.
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T1 - Associations of Rsf-1 overexpression with poor therapeutic response and worse survival in patients with nasopharyngeal carcinoma

AU - Tai, Hui Chun

AU - Huang, Hsuan Ying

AU - Lee, Sung Wei

AU - Lin, Ching Yih

AU - Sheu, Ming Jen

AU - Chang, Shih Lun

AU - Wu, Li Ching

AU - Shiue, Yow Ling

AU - Wu, Wen Ren

AU - Lin, Chun Mao

AU - Li, Chien Feng

PY - 2012/3

Y1 - 2012/3

N2 - Aims: Deregulated chromatin remodelling often leads to aberrant gene expression in cells, thereby implicating tumour development and progression. As a subunit of remodelling and spacing factor complex, Rsf-1 (HBXAP), a novel nuclear protein with histone chaperon function, mediates ATPase-dependent chromatin remodelling and confers tumour aggressiveness in common carcinomas. However, the expression of Rsf-1 has never been reported in nasopharyngeal carcinoma (NPC). This study aimed at evaluating the expression status, associations with clincopathological variables and prognostic implications of Rsf-1 in a well-defined cohort of NPC. Methods: Rsf-1 immunoexpression was retrospectively assessed in biopsies of 108 consecutive NPC patients without initial distant metastasis and treated with consistent guidelines. The results were correlated with the clinicopathological features, therapeutic response, local recurrence-free survival (LRFS), distant metastasis-free survival (DMFS) and disease-specific survival (DSS). Results: Present in 49 cases (45%), Rsf-1 overexpression was associated with N2,3 status (p=0.016), American Joint Committee on Cancer stage 3, 4 (p=0.004), and incomplete therapeutic response (p=0.041). In multivariate analyses, Rsf-1 overexpression not only emerged as the sole independent adverse prognosticator for LRFS (p=0.0002, RR 5.287) but also independently predicted worse DMFS (p=0.0011, RR 3.185) and DSS (p3,4 (p=0.0454) and N 2,3 (p=0.0319), respectively. Conclusion: Rsf-1 overexpression is common and is associated with adverse prognosticators and therapeutic response, which confers tumour aggressiveness through chromatin remodelling, and represents a potential prognostic biomarker in NPC.

AB - Aims: Deregulated chromatin remodelling often leads to aberrant gene expression in cells, thereby implicating tumour development and progression. As a subunit of remodelling and spacing factor complex, Rsf-1 (HBXAP), a novel nuclear protein with histone chaperon function, mediates ATPase-dependent chromatin remodelling and confers tumour aggressiveness in common carcinomas. However, the expression of Rsf-1 has never been reported in nasopharyngeal carcinoma (NPC). This study aimed at evaluating the expression status, associations with clincopathological variables and prognostic implications of Rsf-1 in a well-defined cohort of NPC. Methods: Rsf-1 immunoexpression was retrospectively assessed in biopsies of 108 consecutive NPC patients without initial distant metastasis and treated with consistent guidelines. The results were correlated with the clinicopathological features, therapeutic response, local recurrence-free survival (LRFS), distant metastasis-free survival (DMFS) and disease-specific survival (DSS). Results: Present in 49 cases (45%), Rsf-1 overexpression was associated with N2,3 status (p=0.016), American Joint Committee on Cancer stage 3, 4 (p=0.004), and incomplete therapeutic response (p=0.041). In multivariate analyses, Rsf-1 overexpression not only emerged as the sole independent adverse prognosticator for LRFS (p=0.0002, RR 5.287) but also independently predicted worse DMFS (p=0.0011, RR 3.185) and DSS (p3,4 (p=0.0454) and N 2,3 (p=0.0319), respectively. Conclusion: Rsf-1 overexpression is common and is associated with adverse prognosticators and therapeutic response, which confers tumour aggressiveness through chromatin remodelling, and represents a potential prognostic biomarker in NPC.

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U2 - 10.1136/jclinpath-2011-200413

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