Associations of reactive thrombocytosis with clinical characteristics in pediatric diseases

Jinn Li Wang, Liang Ti Huang, Kuan Hsun Wu, Hui Wen Lin, Man Yan Ho, Hsingjin Eugene Liu

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Reactive thrombocytosis (RT) in pediatric patients is common, but usually without symptoms. The incidence of RT is different depending on age. Mostly, we reason that RT is a phenomenon, nevertheless the diagnostic value of RT is little known. Therefore, the aim of this study was to determine the association of RT and clinical or laboratory characteristics in pediatric diseases. Methods: We retrospectively analyzed the medical records of pediatric patients hospitalized at Wan Fang hospital from January 2002 to July 2009. Thrombocytosis was defined as a platelet count more than 500 × 10 9/L. There were 822 patients enrolled to this study. The clinical parameters, including age, gender, disease type, and hospitalization days, were investigated. The association between RT and clinical manifestations and the relationship of leukocytes, hemoglobin, C-reactive protein, and platelet counts were analyzed. Results: The overall incidence of RT in hospitalized pediatric patients was 6.3%. Infants had a significantly higher incidence (11.3%, p <0.001). Mild RT was found in most patients (83.6%). Infections (75.4%) were the most common cause, followed by perinatal diseases (11.1%). The relationship of RT and age revealed a positive correlation (p = 0.045, r = 0.70 after adjustment). The degree of RT was an independent factor for hospitalization days (p <0.001, r = 0.126 after adjustment). There was a positive correlation between white blood cell count and platelets (p = 0.002, r = 0.017); on the contrary, the relationship between hemoglobin level and platelets was an inverse correlation (p <0.001, r = -0.193). Conclusions: In children, the degree of RT was associated with age, and patients had significantly longer hospitalization days in proportion to the increase in platelet count. Laboratory association revealed that the degree of RT was positively correlated to white cell count and negatively correlated to hemoglobin level. Therefore, the degree of RT might be a predictive factor with regard to hospitalization days in pediatric diseases.

Original languageEnglish
Pages (from-to)261-266
Number of pages6
JournalPediatrics and Neonatology
Volume52
Issue number5
DOIs
Publication statusPublished - Oct 2011

Fingerprint

Thrombocytosis
Pediatrics
Hospitalization
Platelet Count
Incidence
Hemoglobins
Blood Platelets
Hemoglobin C
Leukocyte Count
C-Reactive Protein

Keywords

  • age
  • hemoglobin
  • pediatric
  • reactive thromobocytosis
  • white blood cell count

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Associations of reactive thrombocytosis with clinical characteristics in pediatric diseases. / Wang, Jinn Li; Huang, Liang Ti; Wu, Kuan Hsun; Lin, Hui Wen; Ho, Man Yan; Liu, Hsingjin Eugene.

In: Pediatrics and Neonatology, Vol. 52, No. 5, 10.2011, p. 261-266.

Research output: Contribution to journalArticle

@article{e1db0b283b8047568406eae3a58d0789,
title = "Associations of reactive thrombocytosis with clinical characteristics in pediatric diseases",
abstract = "Background: Reactive thrombocytosis (RT) in pediatric patients is common, but usually without symptoms. The incidence of RT is different depending on age. Mostly, we reason that RT is a phenomenon, nevertheless the diagnostic value of RT is little known. Therefore, the aim of this study was to determine the association of RT and clinical or laboratory characteristics in pediatric diseases. Methods: We retrospectively analyzed the medical records of pediatric patients hospitalized at Wan Fang hospital from January 2002 to July 2009. Thrombocytosis was defined as a platelet count more than 500 × 10 9/L. There were 822 patients enrolled to this study. The clinical parameters, including age, gender, disease type, and hospitalization days, were investigated. The association between RT and clinical manifestations and the relationship of leukocytes, hemoglobin, C-reactive protein, and platelet counts were analyzed. Results: The overall incidence of RT in hospitalized pediatric patients was 6.3{\%}. Infants had a significantly higher incidence (11.3{\%}, p <0.001). Mild RT was found in most patients (83.6{\%}). Infections (75.4{\%}) were the most common cause, followed by perinatal diseases (11.1{\%}). The relationship of RT and age revealed a positive correlation (p = 0.045, r = 0.70 after adjustment). The degree of RT was an independent factor for hospitalization days (p <0.001, r = 0.126 after adjustment). There was a positive correlation between white blood cell count and platelets (p = 0.002, r = 0.017); on the contrary, the relationship between hemoglobin level and platelets was an inverse correlation (p <0.001, r = -0.193). Conclusions: In children, the degree of RT was associated with age, and patients had significantly longer hospitalization days in proportion to the increase in platelet count. Laboratory association revealed that the degree of RT was positively correlated to white cell count and negatively correlated to hemoglobin level. Therefore, the degree of RT might be a predictive factor with regard to hospitalization days in pediatric diseases.",
keywords = "age, hemoglobin, pediatric, reactive thromobocytosis, white blood cell count",
author = "Wang, {Jinn Li} and Huang, {Liang Ti} and Wu, {Kuan Hsun} and Lin, {Hui Wen} and Ho, {Man Yan} and Liu, {Hsingjin Eugene}",
year = "2011",
month = "10",
doi = "10.1016/j.pedneo.2011.06.004",
language = "English",
volume = "52",
pages = "261--266",
journal = "Pediatrics and Neonatology",
issn = "1875-9572",
publisher = "臺灣兒科醫學會",
number = "5",

}

TY - JOUR

T1 - Associations of reactive thrombocytosis with clinical characteristics in pediatric diseases

AU - Wang, Jinn Li

AU - Huang, Liang Ti

AU - Wu, Kuan Hsun

AU - Lin, Hui Wen

AU - Ho, Man Yan

AU - Liu, Hsingjin Eugene

PY - 2011/10

Y1 - 2011/10

N2 - Background: Reactive thrombocytosis (RT) in pediatric patients is common, but usually without symptoms. The incidence of RT is different depending on age. Mostly, we reason that RT is a phenomenon, nevertheless the diagnostic value of RT is little known. Therefore, the aim of this study was to determine the association of RT and clinical or laboratory characteristics in pediatric diseases. Methods: We retrospectively analyzed the medical records of pediatric patients hospitalized at Wan Fang hospital from January 2002 to July 2009. Thrombocytosis was defined as a platelet count more than 500 × 10 9/L. There were 822 patients enrolled to this study. The clinical parameters, including age, gender, disease type, and hospitalization days, were investigated. The association between RT and clinical manifestations and the relationship of leukocytes, hemoglobin, C-reactive protein, and platelet counts were analyzed. Results: The overall incidence of RT in hospitalized pediatric patients was 6.3%. Infants had a significantly higher incidence (11.3%, p <0.001). Mild RT was found in most patients (83.6%). Infections (75.4%) were the most common cause, followed by perinatal diseases (11.1%). The relationship of RT and age revealed a positive correlation (p = 0.045, r = 0.70 after adjustment). The degree of RT was an independent factor for hospitalization days (p <0.001, r = 0.126 after adjustment). There was a positive correlation between white blood cell count and platelets (p = 0.002, r = 0.017); on the contrary, the relationship between hemoglobin level and platelets was an inverse correlation (p <0.001, r = -0.193). Conclusions: In children, the degree of RT was associated with age, and patients had significantly longer hospitalization days in proportion to the increase in platelet count. Laboratory association revealed that the degree of RT was positively correlated to white cell count and negatively correlated to hemoglobin level. Therefore, the degree of RT might be a predictive factor with regard to hospitalization days in pediatric diseases.

AB - Background: Reactive thrombocytosis (RT) in pediatric patients is common, but usually without symptoms. The incidence of RT is different depending on age. Mostly, we reason that RT is a phenomenon, nevertheless the diagnostic value of RT is little known. Therefore, the aim of this study was to determine the association of RT and clinical or laboratory characteristics in pediatric diseases. Methods: We retrospectively analyzed the medical records of pediatric patients hospitalized at Wan Fang hospital from January 2002 to July 2009. Thrombocytosis was defined as a platelet count more than 500 × 10 9/L. There were 822 patients enrolled to this study. The clinical parameters, including age, gender, disease type, and hospitalization days, were investigated. The association between RT and clinical manifestations and the relationship of leukocytes, hemoglobin, C-reactive protein, and platelet counts were analyzed. Results: The overall incidence of RT in hospitalized pediatric patients was 6.3%. Infants had a significantly higher incidence (11.3%, p <0.001). Mild RT was found in most patients (83.6%). Infections (75.4%) were the most common cause, followed by perinatal diseases (11.1%). The relationship of RT and age revealed a positive correlation (p = 0.045, r = 0.70 after adjustment). The degree of RT was an independent factor for hospitalization days (p <0.001, r = 0.126 after adjustment). There was a positive correlation between white blood cell count and platelets (p = 0.002, r = 0.017); on the contrary, the relationship between hemoglobin level and platelets was an inverse correlation (p <0.001, r = -0.193). Conclusions: In children, the degree of RT was associated with age, and patients had significantly longer hospitalization days in proportion to the increase in platelet count. Laboratory association revealed that the degree of RT was positively correlated to white cell count and negatively correlated to hemoglobin level. Therefore, the degree of RT might be a predictive factor with regard to hospitalization days in pediatric diseases.

KW - age

KW - hemoglobin

KW - pediatric

KW - reactive thromobocytosis

KW - white blood cell count

UR - http://www.scopus.com/inward/record.url?scp=80055072235&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80055072235&partnerID=8YFLogxK

U2 - 10.1016/j.pedneo.2011.06.004

DO - 10.1016/j.pedneo.2011.06.004

M3 - Article

C2 - 22036221

AN - SCOPUS:80055072235

VL - 52

SP - 261

EP - 266

JO - Pediatrics and Neonatology

JF - Pediatrics and Neonatology

SN - 1875-9572

IS - 5

ER -