Associations of polyunsaturated fatty acids with residual depression or anxiety in older people with major depression

Ayesha Jadoon, Chih Chiang Chiu, Lindsay McDermott, Phil Cunningham, Sophia Frangou, Ching Jui Chang, I. Wen Sun, Shen Ing Liu, Mong Liang Lu, Kuan Pin Su, Shih Yi Huang, Robert Stewart

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Backgrounds: Depression in late life often follows a chronic course with residual depressive and anxiety symptoms. Levels of omega-3 polyunsaturated fatty acids (PUFAs) have been found to be depleted in people with major depression in the acute stage. Additionally, lower omega-3 PUFA levels have been suggested to be associated with anxiety. The aim of this study was to investigate whether PUFAs levels (omega-3 or omega-6) are correlated with residual depressive or anxiety symptoms in older people with previous depression. Methods: Participants aged 60 years or over with previous major depression in remission were enrolled from outpatient psychiatric services of four hospitals. Participants with residual depressive symptoms were defined as the Hamilton Depression Rating Scale (HDRS) scores > 5, and those with anxiety were defined as sum of scores for the two anxiety subscale of HDRS≥2. The levels of fatty acids in erythrocyte membranes and in plasma were measured separately by gas chromatography. Results: One hundred and thirty two older people with previous major depression (mean age of 68 years, range 60-86 years) were analyzed. Erythrocyte membrane linoleic acid levels had a curvilinear association with depressive symptoms and anxiety symptoms. Plasma linoleic acid levels were found to have a negative linear relationship with depressive symptoms. No significant associations were found between any omega-3 fatty acid level and depressive or anxiety symptoms. Conclusion: Linoleic acid levels may be a possible biomarker for residual depression and anxiety in older people with previous depression. Possible clinical applications need further investigation.

Original languageEnglish
Pages (from-to)918-925
Number of pages8
JournalJournal of Affective Disorders
Volume136
Issue number3
DOIs
Publication statusPublished - Feb 2012

Fingerprint

Unsaturated Fatty Acids
Anxiety
Depression
Omega-3 Fatty Acids
Linoleic Acid
Erythrocyte Membrane
Ambulatory Care
Gas Chromatography
Psychiatry
Fatty Acids
Biomarkers

Keywords

  • Anxiety
  • Late-life depression
  • Omega-3 fatty acids
  • Polyunsaturated fatty acids
  • Residual depression

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Jadoon, A., Chiu, C. C., McDermott, L., Cunningham, P., Frangou, S., Chang, C. J., ... Stewart, R. (2012). Associations of polyunsaturated fatty acids with residual depression or anxiety in older people with major depression. Journal of Affective Disorders, 136(3), 918-925. https://doi.org/10.1016/j.jad.2011.09.007

Associations of polyunsaturated fatty acids with residual depression or anxiety in older people with major depression. / Jadoon, Ayesha; Chiu, Chih Chiang; McDermott, Lindsay; Cunningham, Phil; Frangou, Sophia; Chang, Ching Jui; Sun, I. Wen; Liu, Shen Ing; Lu, Mong Liang; Su, Kuan Pin; Huang, Shih Yi; Stewart, Robert.

In: Journal of Affective Disorders, Vol. 136, No. 3, 02.2012, p. 918-925.

Research output: Contribution to journalArticle

Jadoon, A, Chiu, CC, McDermott, L, Cunningham, P, Frangou, S, Chang, CJ, Sun, IW, Liu, SI, Lu, ML, Su, KP, Huang, SY & Stewart, R 2012, 'Associations of polyunsaturated fatty acids with residual depression or anxiety in older people with major depression', Journal of Affective Disorders, vol. 136, no. 3, pp. 918-925. https://doi.org/10.1016/j.jad.2011.09.007
Jadoon, Ayesha ; Chiu, Chih Chiang ; McDermott, Lindsay ; Cunningham, Phil ; Frangou, Sophia ; Chang, Ching Jui ; Sun, I. Wen ; Liu, Shen Ing ; Lu, Mong Liang ; Su, Kuan Pin ; Huang, Shih Yi ; Stewart, Robert. / Associations of polyunsaturated fatty acids with residual depression or anxiety in older people with major depression. In: Journal of Affective Disorders. 2012 ; Vol. 136, No. 3. pp. 918-925.
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AU - Chang, Ching Jui

AU - Sun, I. Wen

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N2 - Backgrounds: Depression in late life often follows a chronic course with residual depressive and anxiety symptoms. Levels of omega-3 polyunsaturated fatty acids (PUFAs) have been found to be depleted in people with major depression in the acute stage. Additionally, lower omega-3 PUFA levels have been suggested to be associated with anxiety. The aim of this study was to investigate whether PUFAs levels (omega-3 or omega-6) are correlated with residual depressive or anxiety symptoms in older people with previous depression. Methods: Participants aged 60 years or over with previous major depression in remission were enrolled from outpatient psychiatric services of four hospitals. Participants with residual depressive symptoms were defined as the Hamilton Depression Rating Scale (HDRS) scores > 5, and those with anxiety were defined as sum of scores for the two anxiety subscale of HDRS≥2. The levels of fatty acids in erythrocyte membranes and in plasma were measured separately by gas chromatography. Results: One hundred and thirty two older people with previous major depression (mean age of 68 years, range 60-86 years) were analyzed. Erythrocyte membrane linoleic acid levels had a curvilinear association with depressive symptoms and anxiety symptoms. Plasma linoleic acid levels were found to have a negative linear relationship with depressive symptoms. No significant associations were found between any omega-3 fatty acid level and depressive or anxiety symptoms. Conclusion: Linoleic acid levels may be a possible biomarker for residual depression and anxiety in older people with previous depression. Possible clinical applications need further investigation.

AB - Backgrounds: Depression in late life often follows a chronic course with residual depressive and anxiety symptoms. Levels of omega-3 polyunsaturated fatty acids (PUFAs) have been found to be depleted in people with major depression in the acute stage. Additionally, lower omega-3 PUFA levels have been suggested to be associated with anxiety. The aim of this study was to investigate whether PUFAs levels (omega-3 or omega-6) are correlated with residual depressive or anxiety symptoms in older people with previous depression. Methods: Participants aged 60 years or over with previous major depression in remission were enrolled from outpatient psychiatric services of four hospitals. Participants with residual depressive symptoms were defined as the Hamilton Depression Rating Scale (HDRS) scores > 5, and those with anxiety were defined as sum of scores for the two anxiety subscale of HDRS≥2. The levels of fatty acids in erythrocyte membranes and in plasma were measured separately by gas chromatography. Results: One hundred and thirty two older people with previous major depression (mean age of 68 years, range 60-86 years) were analyzed. Erythrocyte membrane linoleic acid levels had a curvilinear association with depressive symptoms and anxiety symptoms. Plasma linoleic acid levels were found to have a negative linear relationship with depressive symptoms. No significant associations were found between any omega-3 fatty acid level and depressive or anxiety symptoms. Conclusion: Linoleic acid levels may be a possible biomarker for residual depression and anxiety in older people with previous depression. Possible clinical applications need further investigation.

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